Procedures and materials for conferring disease resistance in plants

ABSTRACT

The present invention provide nucleic acids encoding polypeptides which confer resistance to Xanthomonas spp and other pathogens. The nucleic acids can be used to produce transgenic plants resistant to the pathogen.

[0001] This application is related to U.S. patent application No. 08/587,680, filed Jan. 17, 1996, which is a continuation in part of copending U.S. patent application No. 08/567,375, filed Dec. 4, 1995, which is a continuation in part of U.S. provisional patent application No., 60/004,645. The '680 application is also a continuation in part of copending U.S. patent application No. 08/475,891, filed Jun. 7, 1995, which is a continuation in part of copending U.S. patent application No. 08/373,374, filed Jan. 17, 1995. These applications are incorporated herein by reference.

STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT

[0002] This invention was made with Government support under Grant No. GM47907, awarded by the National Institutes of Health and Grant No. 9300834, awarded by the United States Department of Agriculture. The Government has certain rights in this invention.

FIELD OF THE INVENTION

[0003] The present invention relates generally to plant molecular biology. In particular, it relates to nucleic acids and methods for conferring disease resistance in plants.

BACKGROUND OF THE INVENTION

[0004] Loci conferring disease resistance have been identified in many plant species. Genetic analysis of many plant-pathogen interactions has demonstrated that plants contain loci that confer resistance against specific races of a pathogen containing a complementary avirulence gene. Molecular characterization of these genes should provide means for conferring disease resistance to a wide variety of crop plants.

[0005] Those plant resistance genes that have been characterized at the molecular level fall into four classes. One gene, Hm1 in corn, encodes a reductase and is effective against the fungal pathogen Cochliobolus carbonum (Johal et al. Science 258:985-987 (1992)). In tomato, the Pto gene confers resistance against Pseudomonas syringae that express the avrPto avirulence gene (Martin et al. Science 262:1432 (1993)). The predicted Pto gene encodes a serine threonine protein kinase. The tomato Cf-9 gene confers resistance to races of the fungus Cladosporium fulvum that carry the avirulence gene Avr9 (Jones et al. Science 266:789-793 (1994). The tomato Cf-9 gene encodes a putatitive extracellular LRR protein. Finally, the RPS2 gene of Arabidopsis thaliana confers resistance to P. syringae that express the avrRpt2 avirulence gene (Bent et al. Science 265:1856-1860 (1994)). RPs2 encodes a protein with an LRR motif and a P-loop motif.

[0006] Bacterial blight disease caused by Xanthomonas spp. infects virtually all crop plants and leads to extensive crop losses worldwide. Bacterial blight disease of rice (Oryza sativa), caused by Xanthomonas oryzae pv. oryzae (Xoo), is an important disease of this crop. Races of Xoo that induce resistant or susceptible reactions on rice cultivars with distinct resistance (Xa) genes have been identified. One source of resistance (Xa21) had been identified in the wild species Oryza longistaminata (Khush et al. in Proceedings of the International Workshop on Bacterial Blight of Rice. (International Rice Research Institute, 1989) and Ikeda et al. Jpn J. Breed 40 (Suppl. 1):280-281 (1990)). Xa21 is a dominant resistance locus that confers resistance to all known isolates of Xoo and is the only characterized Xa gene that carries resistance to Xoo race 6. Genetic and physical analysis of the Xa21 locus has identified a number of tightly linked markers on chromosome 11 (Ronald et al. Mol. Gen. Genet. 236:113-120 (1992)). The molecular mechanisms by which the Xa21 locus confers resistance to this pathogen were not identified, however.

[0007] Considerable effort has been directed toward cloning plant genes conferring resistance to a variety of bacterial, fungal and viral diseases. Only one pest resistance gene has been cloned in monocots. Since monocot crops feed most humans and animals in the world, the identification of disease resistance genes in these plants is particularly important. The present invention addresses these and other needs.

SUMMARY OF THE INVENTION

[0008] The present invention provides isolated nucleic acid constructs comprising an RRK polynucleotide sequence. The sequences can be rice sequences which hybridize to SEQ ID NOs: 1, 4, 6, 8, 10, or 11 under stringent conditions. Also claimed are sequences from cassava which hybdridize to SEQ ID NO: 13), maize sequences which hybridize to SEQ ID NOs: 15, 16), and tomato (e.g., SEQ ID NOs:17, 19, or 21). Exemplary RRK polynucleotide sequences are Xa21 sequences which encode an Xa21 polypeptide as shown below. The RRK polynucleotides encode a protein having a leucine rich repeat motif and/or a cytoplasmic protein kinase domain. The nucleic acid constructs of the invention may further comprise a promoter operably linked to the RRK polynucleotide sequence. The promoter may be a tissue-specific promoter or a constitutive promoter.

[0009] The invention also provides nucleic acid constructs comprising a promoter sequence from an RRK gene linked to a heterologous polynucleotide sequence. Exemplary heterologous polynucleotide sequences include structural genes which confer pathogen resistance on plants.

[0010] The invention further provides transgenic plants comprising a recombinant expression cassette comprising a promoter from an RRK gene operably linked to a polynucleotide sequence as well as transgenic plants comprising a recombinant expression cassette comprising a plant promoter operably linked to an RRK polynucleotide sequence. Although any plant can be used in the invention, rice and tomato plants may be conveniently used.

[0011] The invention further provides methods of enhancing resistance to Xanthomonas and other pathogens in a plant. The methods comprise introducing into the plant a recombinant expression cassette comprising a plant promoter operably linked to an RRK polynucleotide sequence. The methods may be conveniently carried out with rice or tomato plants.

Definitions

[0012] The term “plant” includes whole plants, plant organs (e.g., leaves, stems, roots, etc.), seeds and plant cells and progeny of same. The class of plants which can be used in the methods of the invention is generally as broad as the class of higher plants amenable to transformation techniques, including both monocotyledonous and dicotyledonous plants.

[0013] A “heterologous sequence” is one that originates from a foreign species, or, if from the same species, is substantially modified from its original form. For example, a promoter operably linked to a heterologous structural gene is from a species different from that from which the structural gene was derived, or, if from the same species, one or both are substantially modified from their original form.

[0014] An “RRK gene” is member of a new class of disease resistance genes which encode RRK polypeptides which typically comprise an extracellular LRR domain, a transmembrane domain, and a cytoplasmic protein kinase domain (as shown in e.g., Pto and Fen (Martin et al. Plant Cell 6:1543-1552 (1994)). As used herein, an LRR domain is a region of a repeated unit of about 24 residues as described in U.S. Ser. No. 08/587,680, and found in Cf-9). Using the sequences disclosed here and standard nucleic acid hybridization and/or amplification techniques, one of skill can identify members of this class of genes. For instance, a nucleic acid probe from an Xa21 gene detected polymorphisms that segregated with the blast (Pyricularia oryzae) resistance gene (Pi7) in 58 recombinant inbred lines of rice. The same probe also detected polymorphism in nearly isogenic lines carrying xa5 and Xa10 resistance genes.

[0015] In some preferred embodiments, members of this class of disease resistance genes can be identified by their ability to be amplified by degenerate PCR primers which correspond to the LRR and kinase domains. For instance, primers have been used to isolate homologous genes in tomato, maize and cassava. The maize gene disclosed here has been genetically mapped to a region associated with resistance to Helminthosporium turcicum. Exemplary primers for this purpose are tcaagcaacaatttgtcaggnca (a/g) at (a/c/t) cc (for the LRR domain sequence GQIP) and taacagcacattgcttgatttnan (g/a) tcncg (g/a) tg (the kinase domain sequence HCDIK). These or equivalent primers are then used to amplify the appropriate nucleic acid using the PCR conditions described below.

[0016] An “Xa21 polynucleotide sequence” is a subsequence or full length polynucleotide sequence of an Xa21 gene, such as the rice Xa21 gene, which, when present in a transgenic plant confers resistance to Xanthomonas spp. (e.g., X. oryzae) on the plant. Exemplary polynucleotides of the invention include the coding region of the sequences provided below. An Xa21 polynucleotide is typically at least about 3100 nucleotides to about 6500 nucleotides in length, usually from about 4000 to about 4500 nucleotides.

[0017] An “Xa21 polypeptide” is a gene product of an Xa21 polynucleotide sequence, which has the activity of Xa21, i.e., the ability to confer resistance to Xanthomonas spp. Xa21 polypeptides, like other RRK polypeptides, are characterized by the presence of an extracellular domain comprising a region of leucine rich repeats (LRR) and/or a cytoplasmic protein kinase domain. Exemplary Xa21 polypeptides of the invention include those described below.

[0018] In the expression of transgenes one of skill will recognize that the inserted polynucleotide sequence need not be identical and may be “substantially identical” to a sequence of the gene from which it was derived. As explained below, these variants are specifically covered by this term.

[0019] In the case where the inserted polynucleotide sequence is transcribed and translated to produce a functional RRK polypeptide, one of skill will recognize that because of codon degeneracy, a number of polynucleotide sequences will encode the same polypeptide. These variants are specifically covered by the term “RRK polynucleotide sequence”. In addition, the term specifically includes those full length sequences substantially identical (determined as described below) with an RRK gene sequence and that encode proteins that retain the function of the RRK protein. Thus, in the case of rice RRK genes disclosed here, the above term includes variant polynucleotide sequences which have substantial identity with the sequences disclosed here and which encode proteins capable of conferring resistance to Xanthomonas or other plant diseases and pests on a transgenic plant comprising the sequence.

[0020] Two polynucleotides or polypeptides are said to be “identical” if the sequence of nucleotides or amino acid residues, respectively, in the two sequences is the same when aligned for maximum correspondence as described below. The term “complementary to” is used herein to mean that the complementary sequence is identical to all or a portion of a reference polynucleotide sequence.

[0021] Sequence comparisons between two (or more) polynucleotides or polypeptides are typically performed by comparing sequences of the two sequences over a segment or “comparison window” to identify and compare local regions of sequence similarity. The segment used for purposes of comparison may be at least about 20 contiguous positions, usually about 50 to about 200, more usually about 100 to about 150 in which a sequence may be compared to a reference sequence of the same number of contiguous positions after the two sequences are optimally aligned.

[0022] Optimal alignment of sequences for comparison may be conducted by the local homology algorithm of Smith and Waterman Adv. Appl. Math. 2: 482 (1981), by the homology alignment algorithm of Needleman and Wunsch J. Mol. Biol. 48:443 (1970), by the search for similarity method of Pearson and Lipman Proc. Natl. Acad. Sci. (U.S.A.) 85: 2444 (1988), by computerized implementations of these algorithms (GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin Genetics Software Package, Genetics Computer Group (GCG), 575 Science Dr., Madison, Wis.), or by inspection. “Percentage of sequence identity” is determined by comparing two optimally aligned sequences over a comparison window, wherein the portion of the polynucleotide sequence in the comparison window may comprise additions or deletions (i.e., gaps) as compared to the reference sequence (which does not comprise additions or deletions) for optimal alignment of the two sequences. The percentage is calculated by determining the number of positions at which the identical nucleic acid base or amino acid residue occurs in both sequences to yield the number of matched positions, dividing the number of matched positions by the total number of positions in the window of comparison and multiplying the result by 100 to yield the percentage of sequence identity.

[0023] The term “substantial identity” of polynucleotide sequences means that a polynucleotide comprises a sequence that has at least 60% sequence identity, preferably at least 80%, more preferably at least 90% and most preferably at least 95%, compared to a reference sequence using the programs described above (preferably BESTFIT) using standard parameters. One of skill will recognize that these values can be appropriately adjusted to determine corresponding identity of proteins encoded by two nucleotide sequences by taking into account codon degeneracy, amino acid similarity, reading frame positioning and the like. Substantial identity of amino acid sequences for these purposes normally means sequence identity of at least 40%, preferably at least 60%, more preferably at least 90%, and most preferably at least 95%. Polypeptides which are “substantially similar” share sequences as noted above except that residue positions which are not identical may differ by conservative amino acid changes. Conservative amino acid substitutions refer to the interchangeability of residues having similar side chains. For example, a group of amino acids having aliphatic side chains is glycine, alanine, valine, leucine, and isoleucine; a group of amino acids having aliphatic-hydroxyl side chains is serine and threonine; a group of amino acids having amide-containing side chains is asparagine and glutamine; a group of amino acids having aromatic side chains is phenylalanine, tyrosine, and tryptophan; a group of amino acids having basic side chains is lysine, arginine, and histidine; and a group of amino acids having sulfur-containing side chains is cysteine and methionine. Preferred conservative amino acids substitution groups are: valine-leucine-isoleucine, phenylalanine-tyrosine, lysine-arginine, alanine-valine, and asparagine-glutamine.

[0024] Another indication that nucleotide sequences are substantially identical is if two molecules hybridize to each other under appropriate conditions. Appropriate conditions can be high or low stringency and will be different in different circumstances. Generally, stringent conditions are selected to be about 5° C. to about 20° C. lower than the thermal melting point (Tm) for the specific sequence at a defined ionic strength and pH. The Tm is the temperature (under defined ionic strength and pH) at which 50% of the target sequence hybridizes to a perfectly matched probe. Typically, stringent wash conditions are those in which the salt concentration is about 0.02 molar at pH 7 and the temperature is at least about 60° C. However, nucleic acids which do not hybridize to each other under stringent conditions are still substantially identical if the polypeptides which they encode are substantially identical. This may occur, e.g., when a copy of a nucleic acid is created using the maximum codon degeneracy permitted by the genetic code. For Southern hybridizations, high stringency wash conditions will include at least one wash in 0.1X SSC at 65° C.

[0025] Nucleic acids of the invention can be identified from a cDNA or genomic library prepared according to standard procedures and the nucleic acids disclosed here (typically at least 100 nucleotides to about full length) used as a probe. Low stringency hybridization conditions will typically include at least one wash using 2X SSC at 65° C. The washes are preferrably followed by a subsequent wash using 1X SSC at 65° C.

[0026] As used herein, a homolog of a particular RRK gene (e.g., the rice Xa21 genes disclosed here) is a second gene (either in the same species or in a different species) which encodes a protein having an amino acid sequence having at least 25% identity or 45% similiarity to (determined as described above) to a polypeptide sequence in the first gene product. It is believed that, in general, homologs share a common evolutionary past.

BRIEF DESCRIPTION OF THE DRAWINGS

[0027]FIG. 1 shows the genome organization of the seven Xa21 family members and location of 14 transposon-like elements. Cosmid and BAC clones carrying the family members are designated. Wide bars represent predicted coding regions, fine bars represent noncoding regions, introns are indicated by angled lines, and the non-sequenced regions are shown by straight lines. A gap in the sequence of BAC9 is indicated by “//”. Letters refer to names of Xa21 gene family members and arrows indicate direction of ORFs. The 14 transposon-like elements are numbered and represented by closed triangles.

[0028]FIG. 2A shows the HC region of the sequenced Xa21 gene family members. Wide bars represent predicted coding regions, and fine bars represent non-coding regions. Start and stop codons are indicated. The 5′ flanking regions and downstream regions are grouped into four and two groups, respectively, and are shown in different colors based on sequence identity. The percentage of DNA sequence identity between promoter regions and between classes is shown to the left and right, respectively. The HC region is indicated by a black bar.

[0029]FIG. 2B is a schematic diagram showing a comparison of the predicted amino acid sequences of XA21 and A1. Domains are numbered as follows: I, Presumed signal peptide; II, presumed N terminus; III, LRR; VI, charged; V, presumed transmembrane; VI charged; VII juxtamembrane; VIII, serine/threonine kinase; IX, carboxy tail. The numbers below each domain indicate amino acid identity between XA21 and A1.

[0030]FIG. 3A shows family member D and insertion position of Retrofit. Retrofit carries long terminal repeats (LTRs) (small arrows) and a single, large ORF, encoding a protein with the following domains: gag, protease (PR), integrase (IN), reverse transcriptase (RT), and RNase H (RH). The large arrow indicates direction of the ORF.

[0031]FIG. 3B shows family member E and insertion position of Truncator. Arrows mark the orientation of the inverted repeats. The deduced amino acid sequences of the tomato resistance genes Cf9 and Pto are shown below. In both FIGS. 3A and 3B, the insertion elements are designated by a hatched bar. The presumed deduced amino acid sequences of members D and E are shown by shaded rectangles. Domains representations are as described in the legend to FIG. 2.

[0032]FIG. 4 shows intergenic recombination break point in the Xa21 family members. Boxes represent the ORFs of the designated family members, while narrow boxes represent flanking regions. Same colors indicate a high level of sequence homology. The nucleotides of the presumed recombination break points are indicated in large and bold type. Sequences surrounding the recombination break point are also shown.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0033] This invention relates to plant RRK genes, such as the Xa21 genes of rice. Nucleic acid sequences from RRK genes, in particular Xa21 genes, can be used to confer resistance to Xanthomonas and other pathogens in plants. The invention has use in conferring resistance in all higher plants susceptible to pathogen infection. The invention thus has use over a broad range of types of plants, including species from the genera Juglans, Fragaria, Lotus, Medicago, Onobrychis, Trifolium, Trigonella, Vigna, Citrus, Linum, Geranium, Manihot, Daucus, Arabidopsis, Brassica, Raphanus, Sinapis, Atropa, Capsicum, Datura, Hyoscyamus, Lycopersicon, Nicotiana, Solanum, Petunia, Digitalis, Majorana, Ciahorium, Helianthus, Lactuca, Bromus, Asparagus, Antirrhinum, Heterocallis, Nemesis, Pelargonium, Panieum, Pennisetum, Ranunculus, Senecio, Salpiglossis, Cucumis, Browaalia, Glycine, Pisum, Phaseolus, Lolium, Zea, Avena, Hordeum, Secale, Triticum, and, Sorghum.

[0034] The Example section below, which describes the isolation and characterization of RRK genes in rice, casava, maize and tomato. The methods used to isolate these genes are exemplary of a general approach for isolating Xa21 genes and other RRK genes. The isolated genes can then be used to construct recombinant vectors for transferring RRK gene expression to transgenic plants.

[0035] Generally, the nomenclature and the laboratory procedures in recombinant DNA technology described below are those well known and commonly employed in the art. Standard techniques are used for cloning, DNA and RNA isolation, amplification and purification. Generally enzymatic reactions involving DNA ligase, DNA polymerase, restriction endonucleases and the like are performed according to the manufacturer's specifications. These techniques and various other techniques are generally performed according to Sambrook et al., Molecular Cloning—A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., (1989).

[0036] The isolation of Xa21 and related RRK genes may be accomplished by a number of techniques. For instance, oligonucleotide probes based on the sequences disclosed here can be used to identify the desired gene in a cDNA or genomic DNA library. To construct genomic libraries, large segments of genomic DNA are generated by random fragmentation, e.g. using restriction endonucleases, and are ligated with vector DNA to form concatemers that can be packaged into the appropriate vector. To prepare a cDNA library, mRNA is isolated from the desired organ, such as leaf and a cDNA library which contains the RRK gene transcript is prepared from the mRNA. Alternatively, cDNA may be prepared from mRNA extracted from other tissues in which RRK genes or homologs are expressed.

[0037] The cDNA or genomic library can then be screened using a probe (typically a degenerate probe) based upon the sequence of a cloned RRK gene such as rice Xa21 genes disclosed here. Probes may be used to hybridize with genomic DNA or cDNA sequences to isolate homologous genes in the same or different plant species.

[0038] Alternatively, the nucleic acids of interest can be amplified from nucleic acid samples using amplification techniques. For instance, polymerase chain reaction (PCR) technology to amplify the sequences of the RRK and related genes directly from genomic DNA, from cDNA, from genomic libraries or cDNA libraries. PCR and other in vitro amplification methods may also be useful, for example, to clone nucleic acid sequences that code for proteins to be expressed, to make nucleic acids to use as probes for detecting the presence of the desired mRNA in samples, for nucleic acid sequencing, or for other purposes.

[0039] Appropriate primers and probes for identifying RRK sequences from plant tissues are generated from comparisons of the sequences provided herein. For a general overview of PCR see PCR Protocols: A Guide to Methods and Applications. (Innis, M, Gelfand, D., Sninsky, J. and White, T., eds.), Academic Press, San Diego (1990), incorporated herein by reference.

[0040] Polynucleotides may also be synthesized by well-known techniques as described in the technical literature. See, e.g., Carruthers et al., Cold Spring Harbor Symp. Quant. Biol. 47:411-418 (1982), and Adams et al., J. Am. Chem. Soc. 105:661 (1983). Double stranded DNA fragments may then be obtained either by synthesizing the complementary strand and annealing the strands together under appropriate conditions, or by adding the complementary strand using DNA polymerase with an appropriate primer sequence.

[0041] Isolated sequences prepared as described herein can then be used to provide RRK gene expression and therefore Xanthomonas resistance in desired plants. One of skill will recognize that the nucleic acid encoding a functional RRK protein need not have a sequence identical to the exemplified gene disclosed here. In addition, the polypeptides encoded by the RRK genes, like other proteins, have different domains which perform different functions. Thus, the RRK gene sequences need not be full length, so long as the desired functional domain of the protein is expressed. As explained in detail below, the proteins of the invention comprise an extracellular leucine rich repeat domain, as well as an intracellular kinase domain. Modified protein chains can also be readily designed utilizing various recombinant DNA techniques well known to those skilled in the art. For example, the chains can vary from the naturally occurring sequence at the primary structure level by amino acid substitutions, additions, deletions, and the like. Modification can also include swapping domains from the proteins of the invention with related domains from other pest resistance genes. For example, the extra cellular domain (including the leucine rich repeat region) of the proteins of the invention can be replaced by that of the tomato Cf-9 gene and thus provide resistance to fungal pathogens of rice. These modifications can be used in a number of combinations to produce the final modified protein chain.

[0042] To use isolated RRK sequences in the above techniques, recombinant DNA vectors suitable for transformation of plant cells are prepared. Techniques for transforming a wide variety of higher plant species are well known and described in the technical and scientific literature. See, for example, Weising et al. Ann. Rev. Genet. 22:421-477 (1988).

[0043] A DNA sequence coding for the desired RRK polypeptide, for example a cDNA or a genomic sequence encoding a full length protein, will be used to construct a recombinant expression cassette which can be introduced into the desired plant. An expression cassette will typically comprise the RRK polynucleotide operably linked to transcriptional and translational initiation regulatory sequences which will direct the transcription of the sequence from the RRK gene in the intended tissues of the transformed plant.

[0044] For example, a plant promoter fragment may be employed which will direct expression of the RRK in all tissues of a regenerated plant. Such promoters are referred to herein as “constitutive” promoters and are active under most environmental conditions and states of development or cell differentiation. Examples of constitutive promoters include the cauliflower mosaic virus (CaMV) 35S transcription initiation region, the 1′- or 2′-promoter derived from T-DNA of Agrobacterium tumafaciens, and other transcription initiation regions from various plant genes known to those of skill.

[0045] Alternatively, the plant promoter may direct expression of the RRK gene in a specific tissue or may be otherwise under more precise environmental or developmental control. Such promoters are referred to here as “inducible” promoters. Examples of environmental conditions that may effect transcription by inducible promoters include pathogen attack, anaerobic conditions, or the presence of light.

[0046] Examples of promoters under developmental control include promoters that initiate transcription only in certain tissues, such as leaves, roots, fruit, seeds, or flowers. The operation of a promoter may also vary depending on its location in the genome. Thus, an inducible promoter may become fully or partially constitutive in certain locations.

[0047] The endogenous promoters from the RRK genes of the invention can be used to direct expression of the genes. These promoters can also be used to direct expression of heterologous structural genes. Thus, the promoters can be used in recombinant expression cassettes to drive expression of genes conferring resistance to any number of pathogens, including fungi, bacteria, and the like.

[0048] To identify the promoters, the 5′ portions of the clones described here are analyzed for sequences characteristic of promoter sequences. For instance, promoter sequence elements include the TATA box consensus sequence (TATAAT), which is usually 20 to 30 base pairs upstream of the transcription start site. In plants, further upstream from the TATA box, at positions −80 to −100, there is typically a promoter element with a series of adenines surrounding the trinucleotide G (or T) N G. J. Messing et al., in Genetic Engineering in Plants, pp. 221-227 (Kosage, Meredith and Hollaender, eds. 1983).

[0049] If proper polypeptide expression is desired, a polyadenylation region at the 3′-end of the RRK coding region should be included. The polyadenylation region can be derived from the natural gene, from a variety of other plant genes, or from T-DNA.

[0050] The vector comprising the sequences from an RRK gene will typically comprise a marker gene which confers a selectable phenotype on plant cells. For example, the marker may encode biocide resistance, particularly antibiotic resistance, such as resistance to kanamycin, G418, bleomycin, hygromycin, or herbicide resistance, such as resistance to chlorosluforon or Basta.

[0051] Such DNA constructs may be introduced into the genome of the desired plant host by a variety of conventional techniques. For example, the DNA construct may be introduced directly into the genomic DNA of the plant cell using techniques such as electroporation, PEG poration, particle bombardment and microinjection of plant cell protoplasts or embryogenic callus, or the DNA constructs can be introduced directly to plant tissue using ballistic methods, such as DNA particle bombardment. Alternatively, the DNA constructs may be combined with suitable T-DNA flanking regions and introduced into a conventional Agrobacterium tumefaciens host vector. The virulence functions of the Agrobacterium tumefaciens host will direct the insertion of the construct and adjacent marker into the plant cell DNA when the cell is infected by the bacteria.

[0052] Transformation techniques are known in the art and well described in the scientific and patent literature. The introduction of DNA constructs using polyethylene glycol precipitation is described in Paszkowski et al. Embo J. 3:2717-2722 (1984). Electroporation techniques are described in Fromm et al. Proc. Natl. Acad. Sci. USA 82:5824 (1985). Ballistic transformation techniques are described in Klein et al. Nature 327:70-73 (1987). Using a number of approaches, cereal species such as rye (de la Pena et al., Nature 325:274-276 (1987)), corn (Rhodes et al., Science 240:204-207 (1988)), and rice (Shimamoto et al., Nature 338:274-276 (1989) by electroporation; Li et al. Plant Cell Rep. 12:250-255 (1993) by ballistic techniques) can be transformed.

[0053]Agrobacterium tumefaciens-meditated transformation techniques are well described in the scientific literature. See, for example Horsch et al. Science 233:496-498 (1984), and Fraley et al. Proc. Natl. Acad. Sci. USA 80:4803 (1983). Although Agrobacterium is useful primarily in dicots, certain monocots can be transformed by Agrobacterium. For instance, Agrobacterium transformation of rice is described by Hiei et al, Plant J. 6:271-282 (1994).

[0054] Transformed plant cells which are derived by any of the above transformation techniques can be cultured to regenerate a whole plant which possesses the transformed genotype and thus the desired RRK-controlled phenotype. Such regeneration techniques rely on manipulation of certain phytohormones in a tissue culture growth medium, typically relying on a biocide and/or herbicide marker which has been introduced together with the RRK nucleotide sequences. Plant regeneration from cultured protoplasts is described in Evans et al., Protoplasts Isolation and Culture, Handbook of Plant Cell Culture, pp. 124-176, MacMillilan Publishing Company, New York, 1983; and Binding, Regeneration of Plants, Plant Protoplasts, pp. 21-73, CRC Press, Boca Raton, 1985. Regeneration can also be obtained from plant callus, explants, organs, or parts thereof. Such regeneration techniques are described generally in Klee et al. Ann. Rev. of Plant Phys. 38:467-486 (1987).

[0055] The methods of the present invention are particularly useful for incorporating the RRK polynucleotides into transformed plants in ways and under circumstances which are not found naturally. In particular, the RRK polypeptides may be expressed at times or in quantities which are not characteristic of natural plants.

[0056] One of skill will recognize that after the expression cassette is stably incorporated in transgenic plants and confirmed to be operable, it can be introduced into other plants by sexual crossing. Any of a number of standard breeding techniques can be used, depending upon the species to be crossed.

[0057] The effect of the modification of RRK gene expression can be measured by detection of increases or decreases in mRNA levels using, for instance, Northern blots. In addition, the phenotypic effects of gene expression can be detected by measuring lesion length as in plants. Suitable assays for determining resistance are described in U.S. Ser. No. 08/587,680.

[0058] The following Examples are offered by way of illustration, not limitation.

EXAMPLE 1

[0059] As noted above, Xa21 genes make up a multigene family. Pulsed field gel electrophoresis and genetic analysis have demonstrated that most of the members of the Xa21 gene family are located in a 230 kb genomic region on chromosome 11 linked to at least 8 major resistance genes and 1 QTL for resistance (Song, et al., Science 270:1804 (1995); Ronald, et al., Mol. Gen. Genet. 236:113 (1992).

[0060] This example describes six Xa21 gene family members from the resistant rice line IRBB21, which members are designated A1, A2, C, D, E, and F. Cloning was as described in U.S. Ser. No. 08/587,680; Song, et al., supra and Wang, et al., Plant J. 7, 525 (1995). DNA sequences were determined by using the Sequitherm Long Read Cycle Sequencing Kit (Epicentre Technologies) in combination with the LI-COR Model 4000L Automated Sequencer (LI-COR Inc). To fill in gaps, a primer walking strategy was performed using synthesized primers (Operon) and the Applied Biosystems 373 DNA sequencer. Genebank accession numbers are as follows: A1: U72725 (SEQ ID NO: 4); A2: U72727 (SEQ ID NO: 10); C: U72723 (SEQ ID NO: 6); D: U72726 (SEQ ID NO: 1); E: U72724 (SEQ ID NO: 8); F: U72728 (SEQ ID NO: 12); 3′ flanking region of F: U72729 (SEQ ID NO: 12). The Wisconsin sequence analysis programs GAP and Pileup were used to calculate the percent identity and to carry out multiple alignments of DNA and protein sequences, respectively.

[0061] Sequence data and restriction enzyme analysis of cosmid and bacterial artificial chromosome clones indicated that the seven members are contained on 4 clones (FIG. 1). The first clone, carrying Xa21 (described in U.S. Ser. No. 08/587,680 and Song et al., supra. The Genbank accession number for Xa21 genmomic and cDNA sequences is U37133) and member C, spans a 40 kb region; the second clone includes member D, A1, and A2 and occupies a 150 kb region; clones of 40 kb and 130 kb contain members E and F, respectively. Genetic and molecular data suggests member E is inherited from the susceptible parent IR24 (P. C. Ronald, et al., Mol. Gen. Genet. 236, 113 (1992)).

[0062] The entire coding region, the intron, and 3′ flanking region of the seven family members can be grouped into two classes. One class (designated the Xa21 class) contains Xa21, as well as members D and F (SEQ ID NOs: 1 and 12). The second class (designated the A2 class) contains members A1 (SEQ ID NO:4), A2 (SEQ ID NO:10), C (SEQ ID NO:6), and E (SEQ ID NO:8). Within each class, family members share striking nucleotide sequence identity (98.0% average identity for the members of the Xa21 class; 95.2% average identity for the members of the A2 class); compared to low levels of DNA sequence identity between members of the two classes (eg. 63.5% identity between Xa21 and A2) (FIG. 2A). Only the Xa21 and A1 open reading frames (ORFs) encode receptor kinase-like proteins. The sequence of other family members contain alterations causing a premature truncation of the predicted receptor kinase-like ORF (small deletions in F and C; base pair mutations in A2; or transposon insertions in D and E). At the amino acid level, A1 and XA21 share 68.6% identity overall. As shown in FIG. 2B, Domains I and II, carrying the presumed signal peptide and amino terminus of the protein, are 100% identical whereas the LRR domain (domain III) of XA21 and A1 share a low level of identity (59.5%) and differ in the number of LRRs (23 vs 22 respectively). In the presumed intracellular portion, the catalytic domains (domain VIII) of XA21 and A1 are highly conserved (82% identity), whereas the non-catalytic regions are divergent (64% identity for domain VII (juxtamembrane) and 38.5% identity for domain IX (carboxyl terminus)). The differences observed between members of the two classes suggest that they may differ in function. Indeed, we have found transgenic plants containing the A1 sequence are susceptible to all Xoo isolates tested.

[0063] A remarkable feature of the Xa21 family members is the presence of fourteen transposable element-like sequences (M. A. Grandbastien, et al., Nature 337: 376 (1989); S. E.; White, et al., Proc. Natl. Acad. Sci. U.S.A. 91: 11792 (1994)). The position of these elements is shown in FIG. 1. Twelve elements insert into noncoding regions; whereas two elements, named Retrofit and Truncator, integrate into the coding regions of members D and E, respectively, resulting in disruption of the ORFs of these two members (FIG. 1, number 9 and 13). Retrofit (SEQ ID NO:3) belongs to the Drosophila copia class of retrotransposons and carries a large ORF showing greatest similarity to the ORF of maize Hopscotch (68.6% similarity; 54.6% identity) and tobacco Tnt1 (51.4% similarity; 31.9% identity) (M. A. Grandbastien, et al., Nature 337: 376 (1989); S. E.; White, et al., Proc. Natl. Acad. Sci. U.S.A. 91: 11792 (1994)). The insertion site of this element is located between the 23rd (V) and 24th (P) amino acids of the 22nd LRR creating a truncated molecule, lacking the transmembrane and kinase domains (FIG. 3A). Insertion of Retrofit into a presumed coding region contrasts with the observation in yeast and maize that integration of retrotransposons is biased towards noncoding regions (D. F. Voytas, Science 274: 737 (1996); P. SanMiguel, et al., Science 274: 765 (1996)). The fact that the truncated D confers partial resistance to Xoo suggests that transposition events at the Xa21 locus can alter expression of resistance.

[0064] Truncator, 2913 bp, represents a novel transposon-like sequence carrying 9 bp terminal inverted repeats (TIRs). The sequence shows no significant homology to any sequence in the database and contains no obvious ORFs. Interestingly, insertion of this element into the amino terminus of the kinase domain of member E would presumably result in premature truncation of the receptor kinase resulting in a receptor-like molecule structurally similar to the tomato fungal resistance gene products Cf9 and Cf2 (FIG. 3B) (D. A. Jones, et al., Science, 266: 789 (1994); M. S. Dixon, et al., Cell 84:451 (1996)).

[0065] In addition to the transposition events presented above, recombination between different family members was also found to play an important role in the evolution of the Xa21 locus. A 269 bp highly conserved (HC) region, located immediately downstream of the start codon of all seven family members marks the site of intragenic recombination events (FIG. 2A). The HC region, has a high G/C content (61.8% for Xa21) hallmarked by the typical G/C rich restriction enzyme recognition site Not I. At the amino acid level, the HC region spans domain I and domain H of XA21 and shares nearly 100% identity among seven family members.

[0066] The HC region delimits four classes of DNA sequences (˜1.3 kb) upstream of the HC region. The 5′ flanking region of family member F is divergent from that of other family members (less than 40% identity). The precise breakpoint (from sequence similarity to divergence) between Xa21 and F is located within the HC region, 120 bp downstream from the start codon. This sudden change of sequence identity is unlikely due to random events such as transposon insertion or deletion because such events would presumably lead to an altered coding region. This is not the case; the deduced amino acid sequence of F maintains the receptor kinase like ORF. These results suggest that a recombination event occurred in the HC region resulting in the formation of a chimeric sequence containing the 5′ flanking region of F and a downstream region (including coding region, intron, and 3′ flanking region) of the Xa21 class.

[0067] In further support of the idea that the HC region mediates intragenic recombination, we also observed apparent recombination breakpoints near or within the HC region for gene family members E, A1, and C. For E, the 5′ flanking region is divergent from all other members whereas the 3′ downstream regions belong to the A2 class. The sudden change of DNA identity can be explained by a recombination event between a progenitor A2-type gene and an unknown family member. The likely recombination breakpoint in E is located 105 bp upstream of the HC region since sequences upstream of this site are quite different, compared with a high level of DNA sequence identity downstream of this site.

[0068] The nearly identical DNA sequences of C and A1 provide the most striking example of an HC mediated recombination event. For example, the 5′ flanking region of C shows nearly perfect identity (99.2%) to that of Xa21, whereas the downstream region of C belongs to the A2 class. The high level of identity between the 5′ flanking sequences of Xa21 and C extends 3.8 kb upstream. This upstream region includes the functional promoter for the Xa21 gene (W.-Y. Song, et al., Science 270:1804 (1995)). These results strongly suggest that C was created by a recombination event in the HC region between progenitors of the Xa21 and A2 classes. The likely recombination breakpoint in member C is delimited by two characteristic deletions: one is located at position −37 and is only present in Xa21 class members (Xa21, D, C, and A1); another deletion is located at position 255 and occurs in all A2 class members.

[0069] From these results it is clear that we have identified a highly conserved, G/C rich region in the gene family and that this region appears to be involved in high frequency recombination between family members. Not only is the HC region present in O. longistaminata, but is also present in Xa21 family members of the cultivated rice species O. sativa (The clone RG103, spanning the HC region of an Xa21 gene family member was isolated from O. sativa cultivar IR36 (3, S. Mcouch, et al., Theoret. Appl. Genet. 76:815 (1988)). Genebank accession number of RG103 is U82168. The mechanism for HC region-mediated recombination is unknown; however, two models can be envisioned. First, this region may mediate programmed recombination similar to that observed in African trypanosomes (R. H. A. Plasterk, Trends Genet 8, 403 (1992)). In trypanosomes, antigenic variation is controlled by a variant surface glycoprotein (VSG), which is encoded by a member of a multigene family containing more than 1000 members. Recombination at stretches of highly conserved nucleotides between silent and expressed members of the VSG gene family leads to expression of new antigens. Alternatively, HC mediated recombination may be an example of an ectopic recombination event where the HC region serves as a recombination initiation site (T. D. Petes, et al., Annu. Rev. Genet. 22:147 (1988); A. Nicolas, et al., Nature 338: 35 (1989)). Frequent recombination in this region would maintain the conservation of the HC region but allow flanking sequences to diverge. Over time, mismatch repair would lead to homogenization of the HC region and result in an overall increased G/C content as has been observed in yeast (Brown T., et al., Cell 54, 705 (1988)).

[0070] Evidence for recombination in intergenic regions of the Xa21 family members was also observed. First, sequences in the 5′ flanking region of members C and Xa21 are identical for 3.8 kb and then abruptly diverge. Interestingly, the same site of divergence is observed in the 3′ flanking regions of Xa21 and member F (FIG. 4). The presence of a conserved site of divergence suggests not only that this is a recombination breakpoint but that the Xa21/C cluster and member F are generated from the same progenitor. Second, the sequence of a 14742 bp region spanning the Xa21/C cluster shows 97.7% identity to the corresponding sequence (14871 bp) of the D/A1/A2 cluster (FIG. 1), suggesting these regions evolved through sequence duplication. This duplication process can be explained by a presumed unequal cross-over event in the intergenic region of these two clusters.

EXAMPLE 2

[0071] Using PCR amplification techniques as described in U.S. Ser. No. 08/587,680, Xa21 genes were isolated from cassava (SEQ ID NOS: 13-14), maize (SEQ ID NO: 15-16) and tomato (SEQ ID. NOs: 17-29). The following is a description of the methods used to isolate TRK1-7 from tomato. The same general procedure was used for maize and cassava.

[0072] We designed primers in conserved regions of both the Leucine Rich Repeat (LRR) region and the serine-threonine kinase domain of Xa21. The PCR products should amplify between these two domains and therefore span the transmembrane domain. So far, two sets of primers have proven successful to amplify three homologues of Xa21 in tomato.

[0073] The first clone TRK1 is a cDNA and the encoded polypeptide (SEQ ID NOs:17and 18). This clone is present as one or two copies in the tomato genome and one copy maps to the short arm of chromosome 1 in the proximity of a resistance gene to Xanthomonas campestris pv. vesicatoria (Rx1)(Zu et al. (1995) Genetics 41:675-682).

[0074] The second clone TRK2 (SEQ ID NO:19) is a 496 bp PCR product with an ORF encoding a polypeptide (SEQ ID NO:20). TRK2 maps within a few cM of mcn (FIG. 4) a mutation on chromosome 3 that mimics disease lesions. A third clone TRK3 (SEQ ID Nos: 21 and 22) is a 473 bp fragment and maps to chromosome 8 near an erecta like mutant. TRK4-7 (SEQ ID Nos: 23-29) are further PCR products and encoded polypeptides

[0075] Primers that have been proven useful are as follows.

[0076] 1. LRR region L3a. TCA AGC AAC AAT TTG TCA GGN CA(A/G) AT(A/C/T) CC

[0077] 2. Kinase region K1a. CGC CTT AGG ATT TTC AAG CTT TCC (T/C)TT (G/A)TA NAC K2a. TAA CAG CAC ATT GCT TGA TTT NAN (G/A)TC NCG (G/A)TG K2b. TAA CAG CAC ATT GCT TGA TIT NAN (G/A)TC (G/A)CA (G/A)TG K2c. TAA CAG CAC ATT GCT TGA TTT NAN (G/A)TC (T/C)CT (G/A)TG

[0078] The following combinations of primers are preferred:

[0079] L3a+K1a then L3u|K1u

[0080] L3a|K2a then L3u|K2u

[0081] L3a+K2b then L3u+K2u or

[0082] L3a+K2c then L3u+K2u.

[0083] PCR conditions

[0084] first cycle

[0085] 94 for 30 s

[0086] 55 for 30 s

[0087] 72 for 1 min

[0088] For the next 19 cycles, the annealing temperature drops 1 degree C. every cycle. After 20 cyles, 10 min at 72. After inital amplification as second round of amplification is performed with the following specific primers with 1 microliter of the previous PCR. L3u. TCA AGC AAC AAT TTG TCA K1u. CGC CTT AGG ATT TTC AAG CTT K2u. TAA CAG CAC ATT GCT TGA

[0089] The conditions for this amplification are:

[0090] 35 cycles

[0091] 94 15 sec

[0092] 55 15 s

[0093] 72 1 mn

[0094] after 35 cyles, 72 for 10 min

[0095] The above examples are provided to illustrate the invention but not to limit its scope. Other variants of the invention will be readily apparent to one of ordinary skill in the art and are encompassed by the appended claims. All publications, patents, and patent applications cited herein are hereby incorporated by reference.

0 SEQUENCE LISTING (1) GENERAL INFORMATION: (iii) NUMBER OF SEQUENCES: 53 (2) INFORMATION FOR SEQ ID NO:1: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13341 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (vi) ORIGINAL SOURCE: (A) ORGANISM: Oryza longistaminata (B) STRAIN: IRBB21 (viii) POSITION IN GENOME: (A) CHROMOSOME/SEGMENT: 11 (B) MAP POSITION: 11q, RG103 (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 2367..4205 (D) OTHER INFORMATION: /product= “receptor kinase-like protein” /note= “Xa21 gene family member D” (ix) FEATURE: (A) NAME/KEY: misc_feature (B) LOCATION: 4201..9071 (D) OTHER INFORMATION: /note= “retrofit, a copia-like, transposon-like element” (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 4484..8821 (D) OTHER INFORMATION: /product= “retrofit” /gene= “gag/pol” (ix) FEATURE: (A) NAME/KEY: intron (B) LOCATION: 9915..11712 (ix) FEATURE: (A) NAME/KEY: misc_feature (B) LOCATION: 10020..10975 (D) OTHER INFORMATION: /note= “Krispie, transposon-like element” (ix) FEATURE: (A) NAME/KEY: misc_feature (B) LOCATION: 12626..12750 (D) OTHER INFORMATION: /note= “Pop-O12, transposon-like element” (ix) FEATURE: (A) NAME/KEY: misc_feature (B) LOCATION: 13040..13248 (D) OTHER INFORMATION: /note= “Ds-rice2, transposon-like element” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1: AAGCTTCATT GGTTTCTTCA GTTATACTTA CGTAGGTTTT TCCTGTATAC ATAAATACGT 60 AACAGAGTAA GGGAATTAGA TTGTTTAAAA TAAAATACAT ATAATCTAAT AGCCTAAAAT 120 ATCAGGTCCA CTGACAGTGG CGGATCTAGG ATTTAGAATA TGGGTGGTCC GACCTAATTT 180 TTTCCTAAAC ATACTAAATC TAACGATGGT AATATATACT ATGCAAGTAT AGATAATAGA 240 ATAGACCAAA AGTGTATCAT GCTATATTAA TAAAGCATCT TAAAACATAT ATAATTAATA 300 ATTACCTAAA ATTTTGACTT AAAGAAGCTC ACATGGCTAT AAAAGTTTAA AGAAAATTAC 360 CATACTAATT TTTCTTCTTA TCGGGTCTAC GCCTTCTAAT GGCCATGAAA GTGGTCGTTA 420 TATCTTCTTC CTTCACTCTT AAGAAAACAT CCCGCTTAAT GGATGTGTCT ATACTATCAT 480 CCAAAAGCTC ATCACCCATC TTTTTTCTCA ACCATCATTA GTAAATGCAT CAGTTCTACT 540 ATAATTTAAT ATCACAATGC ACAGGAGTAA AGAGTTCAAA ATTTCAAAAC TGAAAATTGA 600 AAAAAAAGTA AAAAAAAAAT AGAAAACCTT TTTGTTTTGG CTTGGTGCAG GTCTGCACCA 660 GTGCGCTAGT GCGGCACTGC GGCGGCAGCG GCCAAGGTGT CGACGCGCGT GCGTGGCCCG 720 GTGGCGCTCG CTCTCACGAT CTGATCAGAT CGCTGATCGC GTCGGCGTCG CGACTCGCGA 780 GGGCGAGGAG GAGAGCGACA GAGAGTCCTG CGACGGCGCG ACGCTTCGGT TTCTTAATTC 840 CGAACGATTA GATACACCGT ACACGCGCGT GTGGTGTGGG GCCTGTGGTA ATCTAATGGT 900 TTAAAATATT GGGTCCACCA ATTTAAGTGA AAATCGACGG TTAGATATGA TAGAGCTACG 960 TGGCAGCCTA AGAGCGTTTG TAGGAGTCCC ACGTGGCGGT TTGAGAGCGT TTGTAGGAAG 1020 TTTAATGGAC TTTTAGTATA TAATAGATAT TTATAATTTT ATTAAGTACC CTAATTTTCC 1080 CTAAACAATT TTTCTCTCTC ATCGTATTTC CATATATCTT TTTGAGATAA TAATGGATAT 1140 AAACATAGCT AGAAATGTAA ATGTTCACCT TGCATCAATA GGGGATGAAG TTGCTAACCT 1200 TTTAGATCTC CTCGATTTGT ATAATATAAC CAAAATATTT TCACCAAAAA TTTCGTTAAA 1260 CATCCGAGAT ATTTGTTGTT TTTGCCGATC GAGCAAAGAT TAGTAGTCCA GCAGTGTCTG 1320 CACCACCACC ATCGTGATAA TGCATCTTGT GTGTTATTCT TGATGAGAAA ATACGTAGTG 1380 AAAACCACAT ATGTGGTGGA AACTTAGAAA CTACCGTTAG ATCGAGAAAT GGATGTCCAA 1440 GATTCGTCCA CGTCACCAAG AGATAAAATT TAACTCGCAG ATTCACTTAT GAGTTAAAAT 1500 TTTAATGAGA GTTAAATTTT AACTCATGTT GATGTGGACG AATATCGGAC ATCCATTTCT 1560 CGATCCAACG ATAGCTTCCA AGTTTCCACT ACATATGTGG TTTGCACTAT ATATTTTCCC 1620 ATTCTTGATT ATGTGTTTGA GAGCAGCTAG CACAAAGAGA AAAAAAAGCA TCGTTTTTCA 1680 CGCGTATGTT TTCAGAACTG TTAAATGGTG TGTTTTTTGA AAAAACTTTC TATAGAAAAG 1740 TTTCTTTAAA AAATATATTA ATCTATTTTT TAAGTTTAAA ATAATTACTA CTTAATTAAT 1800 TATACACTAA CAGCTTATTT CGTTCTACGT ATCTTGTCAA TTTTCGCTAT TCCTTTCTTC 1860 TCAAACACGG CATTGGATGC TCTCATAGCA CTTGCTCGTT CGGATAGAAG ACTTGACGAA 1920 GACGACCGCT ACAACTTGGT GTGTTATATC GTGCTTTGTT TAGCATAATC ATTACATATA 1980 TTCCATGCCG AAGTGCCGAC GATGAGACCG TGTTCGATGC ATCTTTGTAT GGCATCTAGG 2040 GACAAAGAGC ATAGAGTCCC TACCATAGTA CCTGCTCGCG TAGAAGACTT GACGAGAAGA 2100 CCGACTGCTA CACCTTGGTG TGTAATAATA TCGTGTTGTG TGTACCATGC ATACTCCTTT 2160 AAAACAAATA ATGGTGGTAA CAGTAAATCT GTCATCCCAC CCACTCTCAT TGTAAATTTT 2220 GCAAGTTATC ACTTGAACTT CTTAATACTC CATCCGTTTG CGTGTGTTCT TTCAGAATTT 2280 GCGTGAGCAC TTTTTCTTCT ATATAATCTG TCTAGTCCAT GAGCTAAACC AGCATCTCTC 2340 GCTGTCTTGC CTTGCACTTC TGCACG ATG ATA TCA CTC CCA TTA TTG CTC TTC 2393 Met Ile Ser Leu Pro Leu Leu Leu Phe 1 5 GTC CTG TTG TTC TCT GCG CTG CTG CTC TGC CCT TCA AGC AGT GAC GAC 2441 Val Leu Leu Phe Ser Ala Leu Leu Leu Cys Pro Ser Ser Ser Asp Asp 10 15 20 25 GAT GGT GAT GCT GCC GGC GAC GAA CTC GCG CTG CTC TCT TTC AAG TCA 2489 Asp Gly Asp Ala Ala Gly Asp Glu Leu Ala Leu Leu Ser Phe Lys Ser 30 35 40 TCC CTG CTA TAC CAG GGG GGC CAG TCG CTG GCA TCT TGG AAC ACG TCC 2537 Ser Leu Leu Tyr Gln Gly Gly Gln Ser Leu Ala Ser Trp Asn Thr Ser 45 50 55 GGC CAC GGC CAG CAC TGC ACA TGG GTG GGT GTT GTG TGC GGC CGC CGC 2585 Gly His Gly Gln His Cys Thr Trp Val Gly Val Val Cys Gly Arg Arg 60 65 70 CGC CGC CGG CAC CCA CAC AGG GTG GTG AAG CTG CTG CTG CGC TCC TCC 2633 Arg Arg Arg His Pro His Arg Val Val Lys Leu Leu Leu Arg Ser Ser 75 80 85 AAC CTG TCC GGG ATC ATC TCG CCG TCG CTC GGC AAC CTG TCC TTC CTC 2681 Asn Leu Ser Gly Ile Ile Ser Pro Ser Leu Gly Asn Leu Ser Phe Leu 90 95 100 105 AGG GAG CTG GAC CTC GGC GAC AAC TAC TTC TCC GGC GAG ATA CCA CCG 2729 Arg Glu Leu Asp Leu Gly Asp Asn Tyr Phe Ser Gly Glu Ile Pro Pro 110 115 120 GAG CTC TGC CGT CTC AGC AGG CTT CAG CTG CTG GAG CTG AGC GAT AAC 2777 Glu Leu Cys Arg Leu Ser Arg Leu Gln Leu Leu Glu Leu Ser Asp Asn 125 130 135 TCC ATC CAA GGG AGC ATC CCC GCG GCC ATT GGA GCA TGC ACC AAG TTG 2825 Ser Ile Gln Gly Ser Ile Pro Ala Ala Ile Gly Ala Cys Thr Lys Leu 140 145 150 ACA TCG CTA GAC CTC AGC CAC AAC CAA CTG CGA GGT ATG ATC CCA CGT 2873 Thr Ser Leu Asp Leu Ser His Asn Gln Leu Arg Gly Met Ile Pro Arg 155 160 165 GAG ATT GGT GCC AGC TTG AAA CAT CTC TCG AAT TTG TAC CTT CAC AAA 2921 Glu Ile Gly Ala Ser Leu Lys His Leu Ser Asn Leu Tyr Leu His Lys 170 175 180 185 AAT GGT TTG TCA GGA GAG ATT CCA TCC GCT TTG GGC AAT CTC ACT AGC 2969 Asn Gly Leu Ser Gly Glu Ile Pro Ser Ala Leu Gly Asn Leu Thr Ser 190 195 200 CTC CAG GAG TTT GAT TTG AGC TTC AAC AGA TTA TCA GGA GCT ATA CCT 3017 Leu Gln Glu Phe Asp Leu Ser Phe Asn Arg Leu Ser Gly Ala Ile Pro 205 210 215 TCA TCA CTG GGG CAG CTC AGC AGT CTA TTG AAT ATG AAT TTG GGA CAG 3065 Ser Ser Leu Gly Gln Leu Ser Ser Leu Leu Asn Met Asn Leu Gly Gln 220 225 230 AAC AAT CTA AGT GGG ATG ATC CCC AAT TCT ATC TGG AAC CTT TCG TCT 3113 Asn Asn Leu Ser Gly Met Ile Pro Asn Ser Ile Trp Asn Leu Ser Ser 235 240 245 CTA AGA GCG TTT TGT GTC AGC GAA AAC AAG CTA GGT GGT ATG ATC CCT 3161 Leu Arg Ala Phe Cys Val Ser Glu Asn Lys Leu Gly Gly Met Ile Pro 250 255 260 265 ACA AAT GCA TTC AAA ACC CTT CAC CTC CTC GAG GTG ATA TAT ATG GGC 3209 Thr Asn Ala Phe Lys Thr Leu His Leu Leu Glu Val Ile Tyr Met Gly 270 275 280 ACT AAC CGT TTC CAT GGC AAA ATC CCT GCC TCA GTT GCT AAT GCT TCT 3257 Thr Asn Arg Phe His Gly Lys Ile Pro Ala Ser Val Ala Asn Ala Ser 285 290 295 CAT CTG ACA CGG CTT CAG ATT GAT GGC AAC TTG TTC AGT GGA ATT ATC 3305 His Leu Thr Arg Leu Gln Ile Asp Gly Asn Leu Phe Ser Gly Ile Ile 300 305 310 ACC TCG GGG TTT GGA AGG TTA AGA AAT CTC ACA GAA CTG TAT CTC TGG 3353 Thr Ser Gly Phe Gly Arg Leu Arg Asn Leu Thr Glu Leu Tyr Leu Trp 315 320 325 AGA AAT TTG TTT CAA ACT AGA GAA CAA GAA GAT TGG GGG TTC ATT TCT 3401 Arg Asn Leu Phe Gln Thr Arg Glu Gln Glu Asp Trp Gly Phe Ile Ser 330 335 340 345 GAC CTA ACA AAT TGC TCC AAA TTA CAA ACA TTG AAC TTG GGA GAA AAT 3449 Asp Leu Thr Asn Cys Ser Lys Leu Gln Thr Leu Asn Leu Gly Glu Asn 350 355 360 AAC CTG GGG GGA GTT CTT CCT AAT TCG TTT TCC AAT CTT TCC ACT TCG 3497 Asn Leu Gly Gly Val Leu Pro Asn Ser Phe Ser Asn Leu Ser Thr Ser 365 370 375 CTT AGT TTT CTT GCA CTT CAT TTG AAT AAG ATC ACA GGA AGC ATT CCG 3545 Leu Ser Phe Leu Ala Leu His Leu Asn Lys Ile Thr Gly Ser Ile Pro 380 385 390 AAG GAT ATT GGC AAT CTT ATT GGC TTA CAA CAT CTC TAT CTC TGC AAC 3593 Lys Asp Ile Gly Asn Leu Ile Gly Leu Gln His Leu Tyr Leu Cys Asn 395 400 405 AAC AAT TTC AGA GGG TCT CTT CCA TCA TCG TTG GGC AGG CTT AAA AAC 3641 Asn Asn Phe Arg Gly Ser Leu Pro Ser Ser Leu Gly Arg Leu Lys Asn 410 415 420 425 TTA GGC ATT CTA CTC GCC TAC GAA AAC AAC TTG AGC GGT TCG ATC CCG 3689 Leu Gly Ile Leu Leu Ala Tyr Glu Asn Asn Leu Ser Gly Ser Ile Pro 430 435 440 TTG GCC ATA GGA AAT CTT ACT GAA CTT AAT ATC TTA CTG CTC GGC ACC 3737 Leu Ala Ile Gly Asn Leu Thr Glu Leu Asn Ile Leu Leu Leu Gly Thr 445 450 455 AAC AAA TTC AGT GGT TGG ATA CCA TAC ACA CTC TCA AAC CTC ACA AAC 3785 Asn Lys Phe Ser Gly Trp Ile Pro Tyr Thr Leu Ser Asn Leu Thr Asn 460 465 470 TTG TTG TCA TTA GGC CTT TCA ACT AAT AAC CTT AGT GGT CCA ATA CCC 3833 Leu Leu Ser Leu Gly Leu Ser Thr Asn Asn Leu Ser Gly Pro Ile Pro 475 480 485 AGT GAA TTA TTC AAT ATT CAA ACA CTA TCA ATA ATG ATC AAT GTA TCA 3881 Ser Glu Leu Phe Asn Ile Gln Thr Leu Ser Ile Met Ile Asn Val Ser 490 495 500 505 AAA AAT AAC TTG GAG GGA TCA ATA CCA CAA GAA ATA GGG CAT CTC AAA 3929 Lys Asn Asn Leu Glu Gly Ser Ile Pro Gln Glu Ile Gly His Leu Lys 510 515 520 AAT CTA GTA GAA TTT CAT GCA GAA TCG AAT AGA TTA TCA GGT AAA ATC 3977 Asn Leu Val Glu Phe His Ala Glu Ser Asn Arg Leu Ser Gly Lys Ile 525 530 535 CCT AAC ACG CTT GGT GAT TGC CAG CTC TTA CGG CAT CTT TAT CTG CAA 4025 Pro Asn Thr Leu Gly Asp Cys Gln Leu Leu Arg His Leu Tyr Leu Gln 540 545 550 AAT AAT TTG TTA TCT GGT AGC ATC CCA TCA GCC TTG GGT CAG CTG AAA 4073 Asn Asn Leu Leu Ser Gly Ser Ile Pro Ser Ala Leu Gly Gln Leu Lys 555 560 565 GGT CTC GAA ACT CTT GAT CTC TCA AGC AAC AAT TTG TCA GGC CAG ATA 4121 Gly Leu Glu Thr Leu Asp Leu Ser Ser Asn Asn Leu Ser Gly Gln Ile 570 575 580 585 CCC ACA TCC TTA GCA GAT ATT ACT ATG CTT CAT TCC TTG AAC CTT TCT 4169 Pro Thr Ser Leu Ala Asp Ile Thr Met Leu His Ser Leu Asn Leu Ser 590 595 600 TTC AAC AGC TTT GTG GGG GAA GTG CCA ACC ATG TGAAACAGTC TGTTCTATTA 4222 Phe Asn Ser Phe Val Gly Glu Val Pro Thr Met 605 610 TCCTGGACAT GAGATATACA TGCATGCTCC AGTACATGCG ATGCTCTAGT ACTGGGATAT 4282 GGTTCGTTAG GATAAGGAGA TTATCTCCAA ATTTGTTTCA CCTTCTTATC CATTGTAACT 4342 GAATACTGTA AGCCACGGTA GAGGCTGTTT CTACCACTAT TTAACAGAGA TGCGGCCCAA 4402 GGCAAAGGGT TTAACGCTTC ACATTTTATC ACATGGTATC AGAGCCTTTT TCCACCTCAA 4462 TAGATCGCAT CTTTCATCCA C ATG GCG TCG TCG TCG TCT TCC TCA GGC GCG 4513 Met Ala Ser Ser Ser Ser Ser Ser Gly Ala 1 5 10 GCA GCC GCC AAT CTC CTC CAA GGC CAC TCG GTT TCA GAG AAA CTC GGG 4561 Ala Ala Ala Asn Leu Leu Gln Gly His Ser Val Ser Glu Lys Leu Gly 15 20 25 AAA GCC AAC CAT GCA TTG TGG AAA GCG CAA GTT AGC GCT GCA GTG CGT 4609 Lys Ala Asn His Ala Leu Trp Lys Ala Gln Val Ser Ala Ala Val Arg 30 35 40 GGA GCC CGA TTG CTG GGC TAC CTC AAC GGC GAT ATC AAA GCT CCA GAC 4657 Gly Ala Arg Leu Leu Gly Tyr Leu Asn Gly Asp Ile Lys Ala Pro Asp 45 50 55 GCC GAA CTC TCG GTC ACC ATA GAT GGG AAG ACC ACA ACA AAG CCG AAT 4705 Ala Glu Leu Ser Val Thr Ile Asp Gly Lys Thr Thr Thr Lys Pro Asn 60 65 70 CCG GCA TTT GAA GAT TGG GAG GCC AAT GAC CAG CTT GTT CTT GGC TAT 4753 Pro Ala Phe Glu Asp Trp Glu Ala Asn Asp Gln Leu Val Leu Gly Tyr 75 80 85 90 CTC CTG TCA TCT CTT TCA AGG GAT GTG CTG ATC CAA GTC GCC ACA TGC 4801 Leu Leu Ser Ser Leu Ser Arg Asp Val Leu Ile Gln Val Ala Thr Cys 95 100 105 AAG ACG GCG GCT GAG GCA TGG CGG AGC ATT GAA GCA CTC TAC TCC ACC 4849 Lys Thr Ala Ala Glu Ala Trp Arg Ser Ile Glu Ala Leu Tyr Ser Thr 110 115 120 GGC ACT CGA GCA AGG GCG GTG AAC ACC AGA CTC GCC CTC ACC AAC ACG 4897 Gly Thr Arg Ala Arg Ala Val Asn Thr Arg Leu Ala Leu Thr Asn Thr 125 130 135 AAG AAA GGA ACA ATG AAG ATC GCC GAG TAT GTC GCC AAG ATG CGA GCG 4945 Lys Lys Gly Thr Met Lys Ile Ala Glu Tyr Val Ala Lys Met Arg Ala 140 145 150 CTT GGT GAT GAG ATG GCT GCC GGC GGT CAT CCA CTT GAT GAA GAA GAC 4993 Leu Gly Asp Glu Met Ala Ala Gly Gly His Pro Leu Asp Glu Glu Asp 155 160 165 170 CTT GTC CAG TAC ATC ATC GCT GGG CTA AAT GAA GAC TTC AGC CCG ATC 5041 Leu Val Gln Tyr Ile Ile Ala Gly Leu Asn Glu Asp Phe Ser Pro Ile 175 180 185 GTC TCC AAC CTC TGC AAC AAG TCC GAT CCC ATC ACG GTT GGG GAG CTG 5089 Val Ser Asn Leu Cys Asn Lys Ser Asp Pro Ile Thr Val Gly Glu Leu 190 195 200 TAT TCT CAG CTC GTC AAC TTT GAA ACC CTC CTT GAT CTC TAC CGC AGC 5137 Tyr Ser Gln Leu Val Asn Phe Glu Thr Leu Leu Asp Leu Tyr Arg Ser 205 210 215 ACT GGT CAG GGA GGA GCT GCT TTT GTC GCT AAT CGC GGC AGG GGC GGC 5185 Thr Gly Gln Gly Gly Ala Ala Phe Val Ala Asn Arg Gly Arg Gly Gly 220 225 230 GGC GGC GGC GGG CGC GGC AAC AAC AAC AAC TCC GGC GGC GGC GGC GGC 5233 Gly Gly Gly Gly Arg Gly Asn Asn Asn Asn Ser Gly Gly Gly Gly Gly 235 240 245 250 AGA AGC GCG CCG GGT GGA CGC GGC AGC GGC AGC CAG GGT CGC GGT GGC 5281 Arg Ser Ala Pro Gly Gly Arg Gly Ser Gly Ser Gln Gly Arg Gly Gly 255 260 265 CGT GGA CGC GGC ACA GGA GGC CAA GAC AGG CGC CCT ACT TGC CAA GTT 5329 Arg Gly Arg Gly Thr Gly Gly Gln Asp Arg Arg Pro Thr Cys Gln Val 270 275 280 TGT TTC AAG CGT GGG CAT ACA GCA GCT GAT TGT TGG TAT CGC TTC GAC 5377 Cys Phe Lys Arg Gly His Thr Ala Ala Asp Cys Trp Tyr Arg Phe Asp 285 290 295 GAG GAC TAC GTT GCA GAT GAG AAG CTC GTT GCT GCT GCT ACT AAC TCG 5425 Glu Asp Tyr Val Ala Asp Glu Lys Leu Val Ala Ala Ala Thr Asn Ser 300 305 310 TAT GGT ATA GAT ACA AAT TGG TAT ATT GAT ACA GGT GCT ACA GAT CAC 5473 Tyr Gly Ile Asp Thr Asn Trp Tyr Ile Asp Thr Gly Ala Thr Asp His 315 320 325 330 ATT ACC GGT GAA CTA GAG AAG CTT ACC ACC AAG GAG AAA TAC AAC GGC 5521 Ile Thr Gly Glu Leu Glu Lys Leu Thr Thr Lys Glu Lys Tyr Asn Gly 335 340 345 GGC GAG CAA ATT CAC ACT GCT AGC GGA GCA GGT ATG GAT ATT AGT CAC 5569 Gly Glu Gln Ile His Thr Ala Ser Gly Ala Gly Met Asp Ile Ser His 350 355 360 ATT GGT CAT ACT ATT GTG CAT ACC CCT AGC CGT AAT ATT CAT CTA AAT 5617 Ile Gly His Thr Ile Val His Thr Pro Ser Arg Asn Ile His Leu Asn 365 370 375 AAT GTC CTT TAT GTT CCT CAA GCC AAG AAA AAT CTT ATA TCT GCT AGT 5665 Asn Val Leu Tyr Val Pro Gln Ala Lys Lys Asn Leu Ile Ser Ala Ser 380 385 390 CAA TTA GCC GCT GAT AAT TCT GCT TTT CTT GAA CTT CAC TCG AAA TTC 5713 Gln Leu Ala Ala Asp Asn Ser Ala Phe Leu Glu Leu His Ser Lys Phe 395 400 405 410 TTT TCT ATA AAG GAT CAG GTA ACG AGG GAC GTT CTG CTT GAA GGG AAA 5761 Phe Ser Ile Lys Asp Gln Val Thr Arg Asp Val Leu Leu Glu Gly Lys 415 420 425 TGT AGA CAC GGT CTC TAC CCG ATC CCC AAG TTC TTT GGT CGC TCA ACC 5809 Cys Arg His Gly Leu Tyr Pro Ile Pro Lys Phe Phe Gly Arg Ser Thr 430 435 440 AAC AAA CAA GCC CTT GGT GCC GCC AAG TTA TCC CTG TCT AGG TGG CAT 5857 Asn Lys Gln Ala Leu Gly Ala Ala Lys Leu Ser Leu Ser Arg Trp His 445 450 455 AGC CGT CTA GGA CAT CCG TCT CTT CCT ATT GTT AAG CAA GTC ATT AGC 5905 Ser Arg Leu Gly His Pro Ser Leu Pro Ile Val Lys Gln Val Ile Ser 460 465 470 AGA AAT AAT CTC CCA TGT TCA GTT GAG TCA GTC AAT CAG TCT GTG TGT 5953 Arg Asn Asn Leu Pro Cys Ser Val Glu Ser Val Asn Gln Ser Val Cys 475 480 485 490 AAT GCT TGC CAA GAA GCA AAG AGT CAT CAG TTA CCT TAT ATT AGA TCT 6001 Asn Ala Cys Gln Glu Ala Lys Ser His Gln Leu Pro Tyr Ile Arg Ser 495 500 505 ACT AGT GTG TCT CAA TTT CCT CTT GAA CTT GTT TTT TCT GAT GTT TGG 6049 Thr Ser Val Ser Gln Phe Pro Leu Glu Leu Val Phe Ser Asp Val Trp 510 515 520 GGC CCT GCT CCA GAG TCT GTT GGG AGA AAT AAA TAT TAT GTG AGT TTC 6097 Gly Pro Ala Pro Glu Ser Val Gly Arg Asn Lys Tyr Tyr Val Ser Phe 525 530 535 ATT GAT GAT TTT AGT AAG TTT ACT TGG ATA TAC TTG CTG AAA TAC AAG 6145 Ile Asp Asp Phe Ser Lys Phe Thr Trp Ile Tyr Leu Leu Lys Tyr Lys 540 545 550 TCT GAG GTT TTT GAG AAA TTT AAA GAA TTT CAG GCT TTA GTT GAA CGA 6193 Ser Glu Val Phe Glu Lys Phe Lys Glu Phe Gln Ala Leu Val Glu Arg 555 560 565 570 ATG TTT GAT AGA AAG ATT ATT GCC ATG CAG ACT GAT TGG CGG GGG GGG 6241 Met Phe Asp Arg Lys Ile Ile Ala Met Gln Thr Asp Trp Arg Gly Gly 575 580 585 AGA TAT CAG AAA CTT AAT TCC TTT TTT GCT CAA ATA GGA TTG ATC ATC 6289 Arg Tyr Gln Lys Leu Asn Ser Phe Phe Ala Gln Ile Gly Leu Ile Ile 590 595 600 ATG TGT CAT GTC CTC ACA CTC ATC AGG CAG AAT GGG TCA GCT GAG AGA 6337 Met Cys His Val Leu Thr Leu Ile Arg Gln Asn Gly Ser Ala Glu Arg 605 610 615 AAA CAC CGG CAT ATC GTG GAA GTA GGC CTT TCT CTT TTA TCT TAT GCA 6385 Lys His Arg His Ile Val Glu Val Gly Leu Ser Leu Leu Ser Tyr Ala 620 625 630 TCA ATG CCT CTT AAG TTT TGG GAT GAA GCC TTT GTT GCA GCC ACT TAT 6433 Ser Met Pro Leu Lys Phe Trp Asp Glu Ala Phe Val Ala Ala Thr Tyr 635 640 645 650 CTC ATC AAT CGT ATA CCT AGT AAA ACC ATC CAA AAT TCT ACA CCC CTA 6481 Leu Ile Asn Arg Ile Pro Ser Lys Thr Ile Gln Asn Ser Thr Pro Leu 655 660 665 GAG AAA CTG TTT AAC CAA AAA CCT GAC TAC TCA TCC TTG AGA GTG TTT 6529 Glu Lys Leu Phe Asn Gln Lys Pro Asp Tyr Ser Ser Leu Arg Val Phe 670 675 680 GGT TGT GCA TGT TGG CCT CAT CTT CGC CCT TAC AAT ACA CAC AAA CTC 6577 Gly Cys Ala Cys Trp Pro His Leu Arg Pro Tyr Asn Thr His Lys Leu 685 690 695 CAG TTT CGC TCC AAA CAG TGC GTG TTT TTG GGT TTT AGT ACT CAC CAC 6625 Gln Phe Arg Ser Lys Gln Cys Val Phe Leu Gly Phe Ser Thr His His 700 705 710 AAA GGA TTT AAG TGT CTT GAT GTG TCA TCA GGC CGT GTC TAC ATC TCA 6673 Lys Gly Phe Lys Cys Leu Asp Val Ser Ser Gly Arg Val Tyr Ile Ser 715 720 725 730 AGA GAT GTT GTC TTT GAT GAA AAT GTT TTT CCC TTC TCT ACA CTC CAC 6721 Arg Asp Val Val Phe Asp Glu Asn Val Phe Pro Phe Ser Thr Leu His 735 740 745 TCA AAT GCA GGA GCC AGA CTC AGG TCT GAA ATT CTT TTG TTG CCG TCC 6769 Ser Asn Ala Gly Ala Arg Leu Arg Ser Glu Ile Leu Leu Leu Pro Ser 750 755 760 CCC TTG ACA AAC TAT AAT ACG GCT AGT GCA GGG GGA ACA CAT GTA GTT 6817 Pro Leu Thr Asn Tyr Asn Thr Ala Ser Ala Gly Gly Thr His Val Val 765 770 775 GCA CCA GTG GCT AAT ACT CCA TTA CCT AGT GAT AAT TTA ATT TCT AAT 6865 Ala Pro Val Ala Asn Thr Pro Leu Pro Ser Asp Asn Leu Ile Ser Asn 780 785 790 GCT GCT GAT GTG ACT TCT GGA GAA AAT AGT GCA GCA CAT GAA CAG GAA 6913 Ala Ala Asp Val Thr Ser Gly Glu Asn Ser Ala Ala His Glu Gln Glu 795 800 805 810 ATG GAG AAT GAG CAG GAA ATA GAG AAC GTC ATG CAT GGG AAC GAC GTG 6961 Met Glu Asn Glu Gln Glu Ile Glu Asn Val Met His Gly Asn Asp Val 815 820 825 CAT GGG GAC GCG GCA TCG GGA CCT GTG CTG GAT CAA CCA ACT GCT GAC 7009 His Gly Asp Ala Ala Ser Gly Pro Val Leu Asp Gln Pro Thr Ala Asp 830 835 840 AGC AGC ACT GCG CCG GAC CAG GGA GCT GAC ACC AGT GAC GCG GTC TCT 7057 Ser Ser Thr Ala Pro Asp Gln Gly Ala Asp Thr Ser Asp Ala Val Ser 845 850 855 GGC GCA GCT TCT GAC GCG GGT GGA GAC ACT GCC ACC CTG GGA GCT GGA 7105 Gly Ala Ala Ser Asp Ala Gly Gly Asp Thr Ala Thr Leu Gly Ala Gly 860 865 870 GCA GCA AAT AGC GCA GCA GCA GGT GGT GAA GAA TCC CAG CCG GTG CAG 7153 Ala Ala Asn Ser Ala Ala Ala Gly Gly Glu Glu Ser Gln Pro Val Gln 875 880 885 890 CCT GAT GTG ACG GGT ACA GTA CTG GCT ACA GTA GCC CCT GCA TCG AGA 7201 Pro Asp Val Thr Gly Thr Val Leu Ala Thr Val Ala Pro Ala Ser Arg 895 900 905 CCA CAC ACT CGT CTG CGG AGT GGT ATT CGA AAA GAG AAG GTA TAC ACT 7249 Pro His Thr Arg Leu Arg Ser Gly Ile Arg Lys Glu Lys Val Tyr Thr 910 915 920 GAT GGC ACC GTT AAA TAT GGT TGT TTT TCT TCT ACT GGT GAA CCA CAA 7297 Asp Gly Thr Val Lys Tyr Gly Cys Phe Ser Ser Thr Gly Glu Pro Gln 925 930 935 AAT GAT AAA GAG GCT TTA GGA GAT AAA AAC TGG AGA GAT GCA ATG GAA 7345 Asn Asp Lys Glu Ala Leu Gly Asp Lys Asn Trp Arg Asp Ala Met Glu 940 945 950 ACT GAG TAT AAT GCT TTG ATA AAA AAT GAC ACA TGG CAC CTA GTT CCA 7393 Thr Glu Tyr Asn Ala Leu Ile Lys Asn Asp Thr Trp His Leu Val Pro 955 960 965 970 TAT GAG AAA GGA CAA AAT ATC ATT GGG TGT AAA TGG GTA TAT AAG ATT 7441 Tyr Glu Lys Gly Gln Asn Ile Ile Gly Cys Lys Trp Val Tyr Lys Ile 975 980 985 AAA AGG AAG GCA GAT GGG ACA CTT GAT AGA TAC AAA GCT AGA CTT GTA 7489 Lys Arg Lys Ala Asp Gly Thr Leu Asp Arg Tyr Lys Ala Arg Leu Val 990 995 1000 GCA AAG GGG TTT AAA CAA AGA TAT GGT ATC GAT TAT GAA GAT ACT TTT 7537 Ala Lys Gly Phe Lys Gln Arg Tyr Gly Ile Asp Tyr Glu Asp Thr Phe 1005 1010 1015 AGT CCT GTT GTT AAA GCT GCT ACT ATT AGA ATT ATT CTG TCC ATT GCT 7585 Ser Pro Val Val Lys Ala Ala Thr Ile Arg Ile Ile Leu Ser Ile Ala 1020 1025 1030 GTC TCT AGA GGT TGG AGT CTT AGA CAG TTA GAT GTT CAG AAT GCC TTT 7633 Val Ser Arg Gly Trp Ser Leu Arg Gln Leu Asp Val Gln Asn Ala Phe 1035 1040 1045 1050 CTT CAT GGA TTC TTA GAA GAA GAA GTC TAC ATG CAA CAA CCT CCT GGG 7681 Leu His Gly Phe Leu Glu Glu Glu Val Tyr Met Gln Gln Pro Pro Gly 1055 1060 1065 TTT GAG TCA TCC TCT AAA CCT GAT TAT GTA TGT AAA TTG GAT AAG GCA 7729 Phe Glu Ser Ser Ser Lys Pro Asp Tyr Val Cys Lys Leu Asp Lys Ala 1070 1075 1080 TTA TAT GGG CTG AAA CAA GCA CCA AGG GCG TGG TAT TCC AGG CTG AGT 7777 Leu Tyr Gly Leu Lys Gln Ala Pro Arg Ala Trp Tyr Ser Arg Leu Ser 1085 1090 1095 AAG AAA CTT GTT GAA CTT GGT TTT GAA GCT TCA AAG GCT GAT ACC TCA 7825 Lys Lys Leu Val Glu Leu Gly Phe Glu Ala Ser Lys Ala Asp Thr Ser 1100 1105 1110 TTA TTC TTT CTT AAC AAA GGA GGG ATA CTT ATG TTT GTT TTG GTA TAT 7873 Leu Phe Phe Leu Asn Lys Gly Gly Ile Leu Met Phe Val Leu Val Tyr 1115 1120 1125 1130 GTT GAT GAT ATA ATT GTA GCT AGC TCT ACA GAG AAG GCA ACT ACA GCA 7921 Val Asp Asp Ile Ile Val Ala Ser Ser Thr Glu Lys Ala Thr Thr Ala 1135 1140 1145 CTT CTG AAG GAT CTA AAC AAG GAG TTC GCA CTT AAG GAT TTG GGA GAC 7969 Leu Leu Lys Asp Leu Asn Lys Glu Phe Ala Leu Lys Asp Leu Gly Asp 1150 1155 1160 CTG CAC TAC TTC CTT GGA ATT GAG GTA ACT AAA GTT TCC AAT GGC GTT 8017 Leu His Tyr Phe Leu Gly Ile Glu Val Thr Lys Val Ser Asn Gly Val 1165 1170 1175 ATC TTG ACT CAA GAG AAG TAT GCA AAT GAT CTG CTA AAG AGA GTT AAT 8065 Ile Leu Thr Gln Glu Lys Tyr Ala Asn Asp Leu Leu Lys Arg Val Asn 1180 1185 1190 ATG TCA AAT TGC AAG CCA GTT AGT ACT CCT CTT TCT GTT AGT GAA AAA 8113 Met Ser Asn Cys Lys Pro Val Ser Thr Pro Leu Ser Val Ser Glu Lys 1195 1200 1205 1210 TTA ACT CTA TAT GAG GGA TCA CCC TTG GGT CCT AAT GAT GCA ATA CAA 8161 Leu Thr Leu Tyr Glu Gly Ser Pro Leu Gly Pro Asn Asp Ala Ile Gln 1215 1220 1225 TAT AGA AGT ATA GTT GGT GCT TTA CAA TAC TTG ACC TTG ACA AGA CCT 8209 Tyr Arg Ser Ile Val Gly Ala Leu Gln Tyr Leu Thr Leu Thr Arg Pro 1230 1235 1240 GAC ATA GCT TAT TCA GTA AAC AAA GTC TGT CAG TTT CTT CAT GCT CCT 8257 Asp Ile Ala Tyr Ser Val Asn Lys Val Cys Gln Phe Leu His Ala Pro 1245 1250 1255 ACT ACC AGT CAT TGG ATT GCA GTA AAA AGA ATC CTC AGA TAC TTG AAC 8305 Thr Thr Ser His Trp Ile Ala Val Lys Arg Ile Leu Arg Tyr Leu Asn 1260 1265 1270 CAA TGC ACA AGT CTA GGA CTT CAT ATA CAC AAG AGT GCT TCT ACT CTT 8353 Gln Cys Thr Ser Leu Gly Leu His Ile His Lys Ser Ala Ser Thr Leu 1275 1280 1285 1290 GTT CAT GGG TAT TCT GAT GCA GAC TGG GCA GGT AGT ATA GAT GAC AGA 8401 Val His Gly Tyr Ser Asp Ala Asp Trp Ala Gly Ser Ile Asp Asp Arg 1295 1300 1305 AAA TCA ACA GGA GGA TTT GCA GTA TTT TTG GGT TCT AAT CTT GTG TCC 8449 Lys Ser Thr Gly Gly Phe Ala Val Phe Leu Gly Ser Asn Leu Val Ser 1310 1315 1320 TGG AGT GCT AGG AAA CAA CCT ACT GTG TCA AGG TCA AGC ACA GAG GCA 8497 Trp Ser Ala Arg Lys Gln Pro Thr Val Ser Arg Ser Ser Thr Glu Ala 1325 1330 1335 GAA TAT AAG GCT GTG GCA AAT ACT ACA GCC GAA CTG ATA TGG GTA CAA 8545 Glu Tyr Lys Ala Val Ala Asn Thr Thr Ala Glu Leu Ile Trp Val Gln 1340 1345 1350 ACC TTG TTA AAA GAA TTG GGA ATT GAG TCT CCT AAA GCT GCC AAG ATT 8593 Thr Leu Leu Lys Glu Leu Gly Ile Glu Ser Pro Lys Ala Ala Lys Ile 1355 1360 1365 1370 TGG TGT GAT AAC TTA GGA GCT AAA TAT TTA TCA GCT AAT CCT GTG TTT 8641 Trp Cys Asp Asn Leu Gly Ala Lys Tyr Leu Ser Ala Asn Pro Val Phe 1375 1380 1385 CAT GCA AGG ACA AAG CAT ATA GAG GTT GAT TAT CAT TTT GTA AGA GAA 8689 His Ala Arg Thr Lys His Ile Glu Val Asp Tyr His Phe Val Arg Glu 1390 1395 1400 CGA GTG TCA CAG AAG CTG TTA GAG ATT GAT TTT GTT CCA TCA GGA GAC 8737 Arg Val Ser Gln Lys Leu Leu Glu Ile Asp Phe Val Pro Ser Gly Asp 1405 1410 1415 CAA GTT GCT GAC GGG TTT ACA AAG GCA CTG TCA GCT TGT CTT CTT GAA 8785 Gln Val Ala Asp Gly Phe Thr Lys Ala Leu Ser Ala Cys Leu Leu Glu 1420 1425 1430 AAT TTT AAA CAC AAT CTT AAC CTA GCT AGG TTA TGATTGAGAG GGCTGTGAAA 8838 Asn Phe Lys His Asn Leu Asn Leu Ala Arg Leu 1435 1440 1445 CAGTCTGTTC TATTATCCTG GACATGAGAT ATACGTGCAT GCTCCAGTAC ATGCGATGCT 8898 CCAGTACTGG GATATGGTTC GTTAGGATAA GGAGATTATC TCCAAATTTG TTTCACCTTC 8958 TTATCCATTG TAACTGAATA CTGTAAGCCA CGGTAGAGGC TGTTTCTACC ACTATTTAAC 9018 AGAGATGCGG CCCGAGGCAA AGGGTTTAAC GCTTCACATT TTATCACAAA CCATTGGTGC 9078 TTTCGCAGCT GCATCCGGGA TCTCAATCCA AGGCAATGCC AAACTCTGTG GTGGAATACC 9138 TGATCTACAT CTGCCTCGAT GTTGTCCATT ACTAGAGAAC AGAAAACATT TCCCAGTTCT 9198 ACCTATTTCT GTTTCTCTGG TCGCAGCACT GGCCATCCTC TCATCACTCT ACTTGCTTAT 9258 AACCTGGCAC AAGAGAACTA AAAAGGGAGC CCCTTCAAGA ACTTCCATGA AAGGCCACCC 9318 ATTGGTCTCT TATTCGCAGT TGGTAAAAGC AACAGATGGT TTCGCGCCGA CCAATTTGTT 9378 GGGTTCTGGA TCATTTGGCT CAGTATACAA AGGAAAGCTT AATATCCAAG ATCATGTTGC 9438 AGTGAAGGTA CTAAAGCTTG AAAATCCTAA GGCGCTCAAG AGTTTCACTG CCGAATGTGA 9498 AGCACTACGA AATATGCGAC ATCGAAATCT TGTCAAGATA GTTACAATTT GCTCGAGCAT 9558 TGATAACAGA GGGAACGATT TCAAAGCAAT TGTGTATGAC TTCATGCCCA ACGGCAGTCT 9618 GGAAGATTGG ATACACCCTG AAACAAATGA TCAAGCAGAC CAGAGGCACT TGAATCTGCA 9678 TCGAAGAGTG ACCATACTAC TTGATGTTGC CTGCGCACTG GACTATCTTC ACCGCCATGG 9738 CCCTGAACCT GTTGTACACT GTGATATTAA ATCAAGCAAT GTGCTGTTAG ATTCTGATAT 9798 GGTAGCCCAT GTTGGAGATT TTGGGCTTGC AAGAATACTT GTTGATGGGA CCTCATTGAT 9858 ACAACAGTCA ACAAGCTCGA TGGGATTTAG AGGGACAATT GGCTATGCAG CACCAGGTCA 9918 GCAAGTCCTT CCAGTATTTT GCATTTTCTG ATCTCTAGTG CTATATGAAA TAGTTTTTAC 9978 CTCTAGTGAA ACTGATGGAG AATATAAGTA ATTAATTGAA CTCAGGGGCG AAGCAGAATA 10038 AATCATCGCC GGGGTCACTA CTAACTAATG AACTTGCACT ACTATGAACA GGTTTATCGT 10098 AAATGGCCAA AACACATTTT TACAGGTGGC CAATCGTGTC GCTTATGACT AAAGATCTTT 10158 TCGCTTGTGA CCGGTGCTAC GATAATCACA TGGTGAAATG AATCTTCACA GATATAGCCT 10218 TTAAGTTTAA GCTAGCCATT TGCAGAAAAT GAAAGGGGTG GCTGTCAGAA AAAAAAAACC 10278 ATTTTTTTGT AGTGTGACTA AAACTATGCG TAAGATGGAA CAAAATTATA CATTAATCCT 10338 CCTCCTTACT CATGATCATA TAACTGAAGT TTGAAAACAA AGACAAATCA AATGTTCATA 10398 TTTCAGAACT TCTGAATTAT AGAACCCTAA CTTCCTAATA AACTTTCGGA CTTGAGAAAC 10458 CACCCTAGGG CTAAATTGTG ATGGTAATAA TCAAGAAATT GTGATAATGT TAGTAGGTTA 10518 CCGCCCTCAA CAGCTCGAGC GCTCGAGCGC TCAACCATAA CCCTTCACCC TTGCCATTCT 10578 TCTCGTCCTT GTTACGCCAA GCCGGCGATG CACGCGTGTA CTACTCGAGG ACGATAAGAC 10638 GCGGAAAGTC GAGAAATCGA GATGTGCGGC GATGCAATGC GAAGTGCTCG GTCAAACTAC 10698 CAGAAGAATA TGATGCAACA GGGGAATGGA CTTTCTGGGC TGCCGGCCAT GTGGGCTCAA 10758 GTCTCAGGCG TTTAAGAGCT GATTAATTTT CTATTTTCTA CTTACTAGTC TCGTTCCTAA 10818 TTGCTATTGG GCTTTAACAA AACGGTGTCA CCGGGGTCCA GTAGTTTGCT TGACTGGGGT 10878 ATAGCTAGTA AAAAAGCGAG GGGTACTAGA TGTATGCACG AAATCGTCGG GGTCTACTGA 10938 CCCCGATGGT AGGCTGTAGC GTCGCCCCTG ATTGAACTAA TTAAATTGCA CAAAAATAAG 10998 ATTATTTGCC ATATCTATTC AGATGCTAAA TATAGCTAGT TCATAGAGGT ACAGATTTTT 11058 TTATATAGGA CTCTAGAGCT ACCACACACT CAAATCAAAT TATGGGTGTG TTCTGCTCTA 11118 CACTGCAATA TGAAATGATT ATTACTTCTA CATGAACTGA TGGAGGAGTT TCAGAAGGAT 11178 CAAATTTGAG TAAAATTTTC AATTCTACAT TTAAGAAACA CTTTTTTTTC ATATGCTAGT 11238 TACAATTTTT TATTTCACGA GCTTACATTG ACCATGAAAA ATACTTGGCA CTACTTACTA 11298 ATTCCCACAT GGAGGTAGTG AAAATAATAT AGATACAAAA ACGAAATATC CTATGTTGTG 11358 TGATATACTA TAATCACAAT GAACACAAAC AGGATTCGTA CAAAAGTAAT TAGCCATCAT 11418 AGCAACTGAT TGCTTGGGGT AACTGTATAG CACAATCATA CCAAATTTCT TTAGATATGT 11478 ATCTGTAAAT TAGATTCTTA AAGTTAAATA TGAAATTTCA TTGGTATTTA TGTTTCTTTA 11538 TATAATAAAA ATTAATCCAG CCTTTGCATC TATCATTTGT CCAGACATCC TTGTTATTTG 11598 TGATATTTAA CACGTAAATT TACATAATTA TACATCCAAG TTCTTTTTAT TTAACACTGT 11658 AAATTTCAAA TCGTACATGT TATAAAGAAT GTACTATATT TCCTGCTCAA ACAGAGTATG 11718 GCGTTGGGCT CATTGCATCA ACGCATGGAG ATATTTACAG CTATGGAATT CTAGTGCTGG 11778 AAATAGTAAC CGGGAAGCGG CCAACTGACA GTACATTCAG ACCCGATTTG GGCCTCCGTC 11838 AATACGTTGA ACTGGGCCTA CATGGCAGAG TGACGGATGT TGTTGACACG AAGCTCATTT 11898 TGGATTCTGA GAACTGGCTG AACAGTACAA ATAATTCTCC ATGTAGAAGA ATCACTGAAT 11958 GCATTGTTTG GCTGCTTAGA CTTGGGTTGT CTTGCTCTCA GGAATTGCCA TCGAGTAGAA 12018 CGCCAACCGG AGATATCATC GACGAACTGA ATGCCATCAA ACAGAATCTC TCCGGATTGT 12078 TTCCAGTGTG TGAAGGTGGG AGCCTTGAAT TCTGATGTTA TGTCTCGTAA TGTTTTATTG 12138 CCACTCTTCA GATCGACTTC TGCAGTGGTA TCTACCACAC GATCACTAAA GTCACCGTGG 12198 TTATTTCCTG ATCCAGCATA TCTGATCATG CATGTTCTGT GTTGTATACC TGTATTTTAC 12258 TCTGAATTGC CACACCGCAA CCCTGCATCT GTTTGTTTGG TATACAAAAG ATAGTGATGA 12318 GTTTATTGTT TTAGGGGCTT CCTAGTTGGC GCGTGTGGTG CCGGCACGCA CGCAGCCCGA 12378 GGGTGGGTTT CTTTTTTTTC CATTGTTATT CCGTTGCTTT TTTTCACCAC GGTAGATCTT 12438 TTTTTTCCGG ATTTCCATTT TTTCCGTTGT TTTTCTCTAT CGCTTATGTT GGCGGATTTT 12498 TTTCCGTGGT TTTCTTTCCG AAGACGAGTA TATCTAACGT AACTAACATG TTACTTTTAG 12558 ATAACGATGG TTATTAAGAT AAGATTTTTC TCTGGAAGAT TTTTGTAAGT AACAGATTGA 12618 AAACAAATCT ATACGTGAGG TCAAATTTTG AAAACTTTCA ATCTAGATTT AAAAACTTTT 12678 CAACTCAAAA TTTGAATTTT TGAAGTGAAA ATTTGAAAAC TTTCAAAAAT TACTAGTAAT 12738 CGACAAAAAA AAAATGGAAA TGGAAACGGA AATAGTTTTG CTGTTATACC GATCGTTTCC 12798 ATATTTACCG TATTCTTATA GAAATTACCG TTTCTTATAA TATGGTAATT ACCGTATTTC 12858 TAAATATGTT GATATTTATA GGGCATGTCT CTACTTGACT CACAGTTTAG AGATTGATTG 12918 ACTATTTAAT CAAATCCCTA ACTTGATTGC ATGGCTAAAA TGGAGTTGAT TTCTAATTTA 12978 TATAGTATAG CTTGAATTTA TTTGTAAATA TAACATACTT ATGTAAAGTT AAATATATGT 13038 TTTCTATAGT TTAATGTTTC TGTATTTGTT ACCGGTTTTC GATCTGTACC GACATGTTTC 13098 CATCAGTATT ATTCCATGTC CGGTTTTCCG ATATTTCCGA TATCGTTTTC GTTTCCGACT 13158 TTACCGTTTT CGATTTCATT TCCGAGAAAA ATATGATTAT GGAAATGGTC GAGGCTGTTT 13218 TCCGATCGTT TCCGACCGTT TTCATCTCTA CCCGTAGTAA TAATATATAA CATTTTATCT 13278 CTAATCTTTC TCTCTCTCAT ATCAATGAAA TAATCGCTAA GAGACTGCTA TTAACAAGGG 13338 CTT 13341 (2) INFORMATION FOR SEQ ID NO:2: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 612 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2: Met Ile Ser Leu Pro Leu Leu Leu Phe Val Leu Leu Phe Ser Ala Leu 1 5 10 15 Leu Leu Cys Pro Ser Ser Ser Asp Asp Asp Gly Asp Ala Ala Gly Asp 20 25 30 Glu Leu Ala Leu Leu Ser Phe Lys Ser Ser Leu Leu Tyr Gln Gly Gly 35 40 45 Gln Ser Leu Ala Ser Trp Asn Thr Ser Gly His Gly Gln His Cys Thr 50 55 60 Trp Val Gly Val Val Cys Gly Arg Arg Arg Arg Arg His Pro His Arg 65 70 75 80 Val Val Lys Leu Leu Leu Arg Ser Ser Asn Leu Ser Gly Ile Ile Ser 85 90 95 Pro Ser Leu Gly Asn Leu Ser Phe Leu Arg Glu Leu Asp Leu Gly Asp 100 105 110 Asn Tyr Phe Ser Gly Glu Ile Pro Pro Glu Leu Cys Arg Leu Ser Arg 115 120 125 Leu Gln Leu Leu Glu Leu Ser Asp Asn Ser Ile Gln Gly Ser Ile Pro 130 135 140 Ala Ala Ile Gly Ala Cys Thr Lys Leu Thr Ser Leu Asp Leu Ser His 145 150 155 160 Asn Gln Leu Arg Gly Met Ile Pro Arg Glu Ile Gly Ala Ser Leu Lys 165 170 175 His Leu Ser Asn Leu Tyr Leu His Lys Asn Gly Leu Ser Gly Glu Ile 180 185 190 Pro Ser Ala Leu Gly Asn Leu Thr Ser Leu Gln Glu Phe Asp Leu Ser 195 200 205 Phe Asn Arg Leu Ser Gly Ala Ile Pro Ser Ser Leu Gly Gln Leu Ser 210 215 220 Ser Leu Leu Asn Met Asn Leu Gly Gln Asn Asn Leu Ser Gly Met Ile 225 230 235 240 Pro Asn Ser Ile Trp Asn Leu Ser Ser Leu Arg Ala Phe Cys Val Ser 245 250 255 Glu Asn Lys Leu Gly Gly Met Ile Pro Thr Asn Ala Phe Lys Thr Leu 260 265 270 His Leu Leu Glu Val Ile Tyr Met Gly Thr Asn Arg Phe His Gly Lys 275 280 285 Ile Pro Ala Ser Val Ala Asn Ala Ser His Leu Thr Arg Leu Gln Ile 290 295 300 Asp Gly Asn Leu Phe Ser Gly Ile Ile Thr Ser Gly Phe Gly Arg Leu 305 310 315 320 Arg Asn Leu Thr Glu Leu Tyr Leu Trp Arg Asn Leu Phe Gln Thr Arg 325 330 335 Glu Gln Glu Asp Trp Gly Phe Ile Ser Asp Leu Thr Asn Cys Ser Lys 340 345 350 Leu Gln Thr Leu Asn Leu Gly Glu Asn Asn Leu Gly Gly Val Leu Pro 355 360 365 Asn Ser Phe Ser Asn Leu Ser Thr Ser Leu Ser Phe Leu Ala Leu His 370 375 380 Leu Asn Lys Ile Thr Gly Ser Ile Pro Lys Asp Ile Gly Asn Leu Ile 385 390 395 400 Gly Leu Gln His Leu Tyr Leu Cys Asn Asn Asn Phe Arg Gly Ser Leu 405 410 415 Pro Ser Ser Leu Gly Arg Leu Lys Asn Leu Gly Ile Leu Leu Ala Tyr 420 425 430 Glu Asn Asn Leu Ser Gly Ser Ile Pro Leu Ala Ile Gly Asn Leu Thr 435 440 445 Glu Leu Asn Ile Leu Leu Leu Gly Thr Asn Lys Phe Ser Gly Trp Ile 450 455 460 Pro Tyr Thr Leu Ser Asn Leu Thr Asn Leu Leu Ser Leu Gly Leu Ser 465 470 475 480 Thr Asn Asn Leu Ser Gly Pro Ile Pro Ser Glu Leu Phe Asn Ile Gln 485 490 495 Thr Leu Ser Ile Met Ile Asn Val Ser Lys Asn Asn Leu Glu Gly Ser 500 505 510 Ile Pro Gln Glu Ile Gly His Leu Lys Asn Leu Val Glu Phe His Ala 515 520 525 Glu Ser Asn Arg Leu Ser Gly Lys Ile Pro Asn Thr Leu Gly Asp Cys 530 535 540 Gln Leu Leu Arg His Leu Tyr Leu Gln Asn Asn Leu Leu Ser Gly Ser 545 550 555 560 Ile Pro Ser Ala Leu Gly Gln Leu Lys Gly Leu Glu Thr Leu Asp Leu 565 570 575 Ser Ser Asn Asn Leu Ser Gly Gln Ile Pro Thr Ser Leu Ala Asp Ile 580 585 590 Thr Met Leu His Ser Leu Asn Leu Ser Phe Asn Ser Phe Val Gly Glu 595 600 605 Val Pro Thr Met 610 (2) INFORMATION FOR SEQ ID NO:3: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1445 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3: Met Ala Ser Ser Ser Ser Ser Ser Gly Ala Ala Ala Ala Asn Leu Leu 1 5 10 15 Gln Gly His Ser Val Ser Glu Lys Leu Gly Lys Ala Asn His Ala Leu 20 25 30 Trp Lys Ala Gln Val Ser Ala Ala Val Arg Gly Ala Arg Leu Leu Gly 35 40 45 Tyr Leu Asn Gly Asp Ile Lys Ala Pro Asp Ala Glu Leu Ser Val Thr 50 55 60 Ile Asp Gly Lys Thr Thr Thr Lys Pro Asn Pro Ala Phe Glu Asp Trp 65 70 75 80 Glu Ala Asn Asp Gln Leu Val Leu Gly Tyr Leu Leu Ser Ser Leu Ser 85 90 95 Arg Asp Val Leu Ile Gln Val Ala Thr Cys Lys Thr Ala Ala Glu Ala 100 105 110 Trp Arg Ser Ile Glu Ala Leu Tyr Ser Thr Gly Thr Arg Ala Arg Ala 115 120 125 Val Asn Thr Arg Leu Ala Leu Thr Asn Thr Lys Lys Gly Thr Met Lys 130 135 140 Ile Ala Glu Tyr Val Ala Lys Met Arg Ala Leu Gly Asp Glu Met Ala 145 150 155 160 Ala Gly Gly His Pro Leu Asp Glu Glu Asp Leu Val Gln Tyr Ile Ile 165 170 175 Ala Gly Leu Asn Glu Asp Phe Ser Pro Ile Val Ser Asn Leu Cys Asn 180 185 190 Lys Ser Asp Pro Ile Thr Val Gly Glu Leu Tyr Ser Gln Leu Val Asn 195 200 205 Phe Glu Thr Leu Leu Asp Leu Tyr Arg Ser Thr Gly Gln Gly Gly Ala 210 215 220 Ala Phe Val Ala Asn Arg Gly Arg Gly Gly Gly Gly Gly Gly Arg Gly 225 230 235 240 Asn Asn Asn Asn Ser Gly Gly Gly Gly Gly Arg Ser Ala Pro Gly Gly 245 250 255 Arg Gly Ser Gly Ser Gln Gly Arg Gly Gly Arg Gly Arg Gly Thr Gly 260 265 270 Gly Gln Asp Arg Arg Pro Thr Cys Gln Val Cys Phe Lys Arg Gly His 275 280 285 Thr Ala Ala Asp Cys Trp Tyr Arg Phe Asp Glu Asp Tyr Val Ala Asp 290 295 300 Glu Lys Leu Val Ala Ala Ala Thr Asn Ser Tyr Gly Ile Asp Thr Asn 305 310 315 320 Trp Tyr Ile Asp Thr Gly Ala Thr Asp His Ile Thr Gly Glu Leu Glu 325 330 335 Lys Leu Thr Thr Lys Glu Lys Tyr Asn Gly Gly Glu Gln Ile His Thr 340 345 350 Ala Ser Gly Ala Gly Met Asp Ile Ser His Ile Gly His Thr Ile Val 355 360 365 His Thr Pro Ser Arg Asn Ile His Leu Asn Asn Val Leu Tyr Val Pro 370 375 380 Gln Ala Lys Lys Asn Leu Ile Ser Ala Ser Gln Leu Ala Ala Asp Asn 385 390 395 400 Ser Ala Phe Leu Glu Leu His Ser Lys Phe Phe Ser Ile Lys Asp Gln 405 410 415 Val Thr Arg Asp Val Leu Leu Glu Gly Lys Cys Arg His Gly Leu Tyr 420 425 430 Pro Ile Pro Lys Phe Phe Gly Arg Ser Thr Asn Lys Gln Ala Leu Gly 435 440 445 Ala Ala Lys Leu Ser Leu Ser Arg Trp His Ser Arg Leu Gly His Pro 450 455 460 Ser Leu Pro Ile Val Lys Gln Val Ile Ser Arg Asn Asn Leu Pro Cys 465 470 475 480 Ser Val Glu Ser Val Asn Gln Ser Val Cys Asn Ala Cys Gln Glu Ala 485 490 495 Lys Ser His Gln Leu Pro Tyr Ile Arg Ser Thr Ser Val Ser Gln Phe 500 505 510 Pro Leu Glu Leu Val Phe Ser Asp Val Trp Gly Pro Ala Pro Glu Ser 515 520 525 Val Gly Arg Asn Lys Tyr Tyr Val Ser Phe Ile Asp Asp Phe Ser Lys 530 535 540 Phe Thr Trp Ile Tyr Leu Leu Lys Tyr Lys Ser Glu Val Phe Glu Lys 545 550 555 560 Phe Lys Glu Phe Gln Ala Leu Val Glu Arg Met Phe Asp Arg Lys Ile 565 570 575 Ile Ala Met Gln Thr Asp Trp Arg Gly Gly Arg Tyr Gln Lys Leu Asn 580 585 590 Ser Phe Phe Ala Gln Ile Gly Leu Ile Ile Met Cys His Val Leu Thr 595 600 605 Leu Ile Arg Gln Asn Gly Ser Ala Glu Arg Lys His Arg His Ile Val 610 615 620 Glu Val Gly Leu Ser Leu Leu Ser Tyr Ala Ser Met Pro Leu Lys Phe 625 630 635 640 Trp Asp Glu Ala Phe Val Ala Ala Thr Tyr Leu Ile Asn Arg Ile Pro 645 650 655 Ser Lys Thr Ile Gln Asn Ser Thr Pro Leu Glu Lys Leu Phe Asn Gln 660 665 670 Lys Pro Asp Tyr Ser Ser Leu Arg Val Phe Gly Cys Ala Cys Trp Pro 675 680 685 His Leu Arg Pro Tyr Asn Thr His Lys Leu Gln Phe Arg Ser Lys Gln 690 695 700 Cys Val Phe Leu Gly Phe Ser Thr His His Lys Gly Phe Lys Cys Leu 705 710 715 720 Asp Val Ser Ser Gly Arg Val Tyr Ile Ser Arg Asp Val Val Phe Asp 725 730 735 Glu Asn Val Phe Pro Phe Ser Thr Leu His Ser Asn Ala Gly Ala Arg 740 745 750 Leu Arg Ser Glu Ile Leu Leu Leu Pro Ser Pro Leu Thr Asn Tyr Asn 755 760 765 Thr Ala Ser Ala Gly Gly Thr His Val Val Ala Pro Val Ala Asn Thr 770 775 780 Pro Leu Pro Ser Asp Asn Leu Ile Ser Asn Ala Ala Asp Val Thr Ser 785 790 795 800 Gly Glu Asn Ser Ala Ala His Glu Gln Glu Met Glu Asn Glu Gln Glu 805 810 815 Ile Glu Asn Val Met His Gly Asn Asp Val His Gly Asp Ala Ala Ser 820 825 830 Gly Pro Val Leu Asp Gln Pro Thr Ala Asp Ser Ser Thr Ala Pro Asp 835 840 845 Gln Gly Ala Asp Thr Ser Asp Ala Val Ser Gly Ala Ala Ser Asp Ala 850 855 860 Gly Gly Asp Thr Ala Thr Leu Gly Ala Gly Ala Ala Asn Ser Ala Ala 865 870 875 880 Ala Gly Gly Glu Glu Ser Gln Pro Val Gln Pro Asp Val Thr Gly Thr 885 890 895 Val Leu Ala Thr Val Ala Pro Ala Ser Arg Pro His Thr Arg Leu Arg 900 905 910 Ser Gly Ile Arg Lys Glu Lys Val Tyr Thr Asp Gly Thr Val Lys Tyr 915 920 925 Gly Cys Phe Ser Ser Thr Gly Glu Pro Gln Asn Asp Lys Glu Ala Leu 930 935 940 Gly Asp Lys Asn Trp Arg Asp Ala Met Glu Thr Glu Tyr Asn Ala Leu 945 950 955 960 Ile Lys Asn Asp Thr Trp His Leu Val Pro Tyr Glu Lys Gly Gln Asn 965 970 975 Ile Ile Gly Cys Lys Trp Val Tyr Lys Ile Lys Arg Lys Ala Asp Gly 980 985 990 Thr Leu Asp Arg Tyr Lys Ala Arg Leu Val Ala Lys Gly Phe Lys Gln 995 1000 1005 Arg Tyr Gly Ile Asp Tyr Glu Asp Thr Phe Ser Pro Val Val Lys Ala 1010 1015 1020 Ala Thr Ile Arg Ile Ile Leu Ser Ile Ala Val Ser Arg Gly Trp Ser 1025 1030 1035 1040 Leu Arg Gln Leu Asp Val Gln Asn Ala Phe Leu His Gly Phe Leu Glu 1045 1050 1055 Glu Glu Val Tyr Met Gln Gln Pro Pro Gly Phe Glu Ser Ser Ser Lys 1060 1065 1070 Pro Asp Tyr Val Cys Lys Leu Asp Lys Ala Leu Tyr Gly Leu Lys Gln 1075 1080 1085 Ala Pro Arg Ala Trp Tyr Ser Arg Leu Ser Lys Lys Leu Val Glu Leu 1090 1095 1100 Gly Phe Glu Ala Ser Lys Ala Asp Thr Ser Leu Phe Phe Leu Asn Lys 1105 1110 1115 1120 Gly Gly Ile Leu Met Phe Val Leu Val Tyr Val Asp Asp Ile Ile Val 1125 1130 1135 Ala Ser Ser Thr Glu Lys Ala Thr Thr Ala Leu Leu Lys Asp Leu Asn 1140 1145 1150 Lys Glu Phe Ala Leu Lys Asp Leu Gly Asp Leu His Tyr Phe Leu Gly 1155 1160 1165 Ile Glu Val Thr Lys Val Ser Asn Gly Val Ile Leu Thr Gln Glu Lys 1170 1175 1180 Tyr Ala Asn Asp Leu Leu Lys Arg Val Asn Met Ser Asn Cys Lys Pro 1185 1190 1195 1200 Val Ser Thr Pro Leu Ser Val Ser Glu Lys Leu Thr Leu Tyr Glu Gly 1205 1210 1215 Ser Pro Leu Gly Pro Asn Asp Ala Ile Gln Tyr Arg Ser Ile Val Gly 1220 1225 1230 Ala Leu Gln Tyr Leu Thr Leu Thr Arg Pro Asp Ile Ala Tyr Ser Val 1235 1240 1245 Asn Lys Val Cys Gln Phe Leu His Ala Pro Thr Thr Ser His Trp Ile 1250 1255 1260 Ala Val Lys Arg Ile Leu Arg Tyr Leu Asn Gln Cys Thr Ser Leu Gly 1265 1270 1275 1280 Leu His Ile His Lys Ser Ala Ser Thr Leu Val His Gly Tyr Ser Asp 1285 1290 1295 Ala Asp Trp Ala Gly Ser Ile Asp Asp Arg Lys Ser Thr Gly Gly Phe 1300 1305 1310 Ala Val Phe Leu Gly Ser Asn Leu Val Ser Trp Ser Ala Arg Lys Gln 1315 1320 1325 Pro Thr Val Ser Arg Ser Ser Thr Glu Ala Glu Tyr Lys Ala Val Ala 1330 1335 1340 Asn Thr Thr Ala Glu Leu Ile Trp Val Gln Thr Leu Leu Lys Glu Leu 1345 1350 1355 1360 Gly Ile Glu Ser Pro Lys Ala Ala Lys Ile Trp Cys Asp Asn Leu Gly 1365 1370 1375 Ala Lys Tyr Leu Ser Ala Asn Pro Val Phe His Ala Arg Thr Lys His 1380 1385 1390 Ile Glu Val Asp Tyr His Phe Val Arg Glu Arg Val Ser Gln Lys Leu 1395 1400 1405 Leu Glu Ile Asp Phe Val Pro Ser Gly Asp Gln Val Ala Asp Gly Phe 1410 1415 1420 Thr Lys Ala Leu Ser Ala Cys Leu Leu Glu Asn Phe Lys His Asn Leu 1425 1430 1435 1440 Asn Leu Ala Arg Leu 1445 (2) INFORMATION FOR SEQ ID NO:4: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 8416 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (vi) ORIGINAL SOURCE: (A) ORGANISM: Oryza longistaminata (B) STRAIN: IRBB21 (viii) POSITION IN GENOME: (A) CHROMOSOME/SEGMENT: 11 (B) MAP POSITION: 11q, RG103 (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: join(4771..7384, 7676..8052) (D) OTHER INFORMATION: /product= “receptor kinase-like protein” /note= “Xa21 gene family member A1” (ix) FEATURE: (A) NAME/KEY: misc_feature (B) LOCATION: 7432..7614 (D) OTHER INFORMATION: /note= “Snap-Ol1, transposon-like element” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4: GCCGTCGATC TGTCATTTTG AAACGGCCCA TTCTTTTCCA TCTATATGCA TTCATGAAAT 60 ACATGGTATA TCCCATCGAT CGGACATCAC CTGTTAGCGC GTACGCCATC GTCGTCATCA 120 ACCTAGCTAG GGCAAACGCA CCTTACTGAG CTCCGTCCTC CGATCGCCAC CATCACCAAT 180 GAACAAGCTG CTGCGGCCTC TCGGTGGCCT GAGGTTGCTC AACCGAGAAG AACATCCGTT 240 CCGATGCTTC TCCTCCTCCA TCGATCTCGT CTTCCCAGGT CGCCGCCGCC GCCACATGGC 300 AACCACCGTG ACCCACCCGC CGCCAACGGA ATCCGCTGGT TCGACGGCGG CGGCCGCGAC 360 TGCTGACCCG GGCTCGGTGA TGCTGGAACG TTGGGGCTGC CTCAGGGGCT CCACGGCGGC 420 GAACGTAGTC GCCGACGACA ACACCGCGGG AGTTCCGCAC CTTCCGCGGC CAACCCCTCC 480 GGTCGCCTCG TCCGGGTTGC GCCGGGATCT CCTTCATCTG CTTCGATCGC GGGGTTGATG 540 GCTACGTCAT CGCGGCTCAC GGCGACTCTG TCCTCTTCCG GATGAGTTGG AACGACTACT 600 TCGTCTACAT GGCCGCCGCC GGCAAGCCGC CGTCGCTGAC GCTGCTCCCC GTCTGCGACA 660 TCCCCATGAA CGAGCGCTGC TGGGTCAGCA AGGACCGTTT CAAGGACGCT TCCGCACCAC 720 GGGCCGGGTG TTCGACCAGC AGGACACCGG CATCCTACGC CTCCGCGGCG ACGACGGCGG 780 TGAGGAGGCG CCGCTCTAGT GGCGCAGTCC AGATCGCGCA CGAGCCGCCG TTCGACACGG 840 CCGAGCTCTG CGTGCTCCGC CCCGGCCACG GCGAGTGGGA GCTCAAGATG GCGGTGCCCA 900 TCGTCCACCA TGACAGCTTG AATCTTATAA CAAACCTTGC TGAAGCTGAC AAATTCTAGC 960 CCCCAGCCAT GAAGTTGGAA AAATCAATTT CCGATTACAC AAATTGGTTA ATACGCAACC 1020 ATTTAGTGCT CTTAACATGA CCAGGTTTTA CATGTTCGTT CGGCTCTTAG AATCTGACAA 1080 GACCTTATCT GCTCTGGGCG TCCCCAGCCG AAATTCCATT AGTTTTCTCG GAGGCTTGTC 1140 AGAACAGCGT AAAGGGACAA TAGGACTGCC TTCAAGATGA GGCGATATAA GAGGGGATCA 1200 ACAGACAAAT ATTGCACATA TAAAACTTAC AGAAGTTGAT GTAGATGATG AGACGACCAC 1260 CACACTAGGC AAAGACCAGG TGTATAGTTG TACTCAACAA ATCACAGAGG TAGTGAGAGA 1320 TCGCTACGAT CTACTGGTCG AAGATCAGGT GTAGGCGTAT TCTCGATCAC CTGAAGAAGA 1380 ATCTTTAGGT GTTGAGAGAT CGCTACTATC TACTGGTCAA TACTAGTAAA AAAACCTCAT 1440 AGAGATCGGC ACTATAGGTG CCGGAACAGC TAAAACCGGC ACCTATAATA CTTTTCCCTC 1500 CTCCGTGGAC TCAAAGCACG TAAAACCGAC ACCTTTAAGC AACTATAGGT GCCGGTTCTA 1560 AAGAAGAACC GACACCTATA GTATAGGTGC TGGTTTTTTA AAAAAACCCG ACACCTTTAA 1620 TATAATATAG GTGTCGGTTC TTCTTTAAAA CCGACACCAA TAATAAATTA TACGTGTCGG 1680 TTTTTTAATA AAACCGGCAC CTATCCAAAC CGAGCCTAGC TGTCGAGTCG AGCCAATCCA 1740 GGCTGACGCA TATATTAGTC TCGTCCTTAT CGCCTCGTCT CTCTCTCTCT CTCTCTCTCT 1800 CTCTTCTCTC TCGCCTCTCT GTGTAGCGCG CGGCGGTGGT CGGGCGGCGT CCCGGCGTAG 1860 GCAACAGTGG TGGCGAGATG GGAGGCGGTG GCGCATCACA GCTATTCACT TTAGCGCATT 1920 GAATAATAAT CGGCATCATG ATCTACTTAT GGTTCGTGCA AGGGGGAAGA TTGTAGATAC 1980 ACATGGTCAC AGCTAAGTGC TATGATCGCG GCTCATCTCT CCAAATAGAT TCATGCCATC 2040 CGTACTTAAA CAGAACCTTA TGTTCCGTGC ATCCTTTCTG AAGTCTTGAA ATGTTTTATC 2100 GATGTTTTAC CACTACGACC CATCTGTAGG GTGTCTCGCA TCCCGTCTTG TTTATGTTTT 2160 TATGTGTGCC AGCGCACCAT TCTAGCACGC GCTTTGTTCC TGAACAAACA CCTTAGCCGT 2220 GGTATTAAAT GGAAATACTG CATGATCATA GCAGGAACTC TCTTCTTCGA AGGATGTCCG 2280 TCAACATCAC CTAGGTCATC TCGTCTAATC TTATATCGTA GTGCCTTACA AACCAGGCGT 2340 GCTTCTAGGT TCTCGTACTC CTCAACGCGA TAGAGGATAC AATCATTCAG ACATACGTGT 2400 ATCTTCTGTA CTTCCAGTCC GAGAGGGCAG ATTACCTTTT TAGCTTCGTA CGTTGTTTCG 2460 AGCAATTCGT TTCCCTCGGG AAGAATATTC TTTACGAGTT TCAATAACTC GCCAAATGCC 2520 TTGTCAGTCA CACCATATTT TGCCTTCCAT TGTCAGAATT CCAGTGTGGT ACCCAACTTT 2580 TTGTGCTCCT ATTCGCAACC TGGGTACAAG GACGTTTTGT GGTATGCTAA CATCCGGTCC 2640 AATTTCTAGA CCAACTTTTT CACTTTTGCA GTCATTTTTT ACATCGCACA ACATTTGACC 2700 AAGATTATCC GTACCGCCGT TTTCTTCAAC AGCTCTGTCC GCCTCGCCTA TTGTATTTTC 2760 TGCAAATCCA TCATATTGAG CCCAGTCTGA AATGTTGTCG TCTTCTTATT AATTTTCTTC 2820 TATTGCAACC CCTAACTCTC CGTGCAAGGT CTAACAATTA TAGCCAGGTA TGAATCCCGA 2880 TTCCAACAAG TGGATATGAA GACTTCTTAG ATGTAGAATA CTCCTTCTGG TTTTTGCACT 2940 TTTGCATGGA CAACATATAA AACCCTTAGG CTTGTGGGCA TTGGCCACAC TCAAAAAATA 3000 ATGCACGTCA TCAATAAACT CCTTCGACCG TCATTCTGCA GTGTACATCC ATTACCGATT 3060 CATCTACATT AGGAGATAAT AATTGTAAAG GAAGTCCACA AAAGTGAAAC TACTTAAATA 3120 ATCATATAAT AATTTAAAAT ATCATAATTA AATTGAAAAC TGACGGTTTT AATGTATTCT 3180 TCTTATTTCT AACGATTTTA ACGAGTTTTA AATGGACTTA ATCGGAGTCA TGATTAACTA 3240 TTTATAAATT TTATCTGTCT CAATAAATTG TAAATATATT TTTCCATGTA TTATCCTTGT 3300 TTAATTATTT TTAAAAGTTC TAAACATATT TTTAATGCAT TCTACTTATT TCTAACTATT 3360 TTAAAGATTT TCAAATGGAC TTAGTTTTCT ATTTTTATTC TTCATTTTCT ATATTTGCCC 3420 TTTGTTGTCT CTTTTTAACA ATTTTATACA AATATTTATA ATTTTATTAA GTACCCTAAT 3480 TTTCCCTAAA CAATTTTTCT CTCTCATCGT ATTTCCATAT ATCTTTTTGA GATAATAATG 3540 GATATAAACA TAGCTAGAAA TGTAAATGTT CACCTTGCAT CAATAGGGGA TGAAGTTGCT 3600 AACCTTTTAG ATCTCCTCGA TTTGTATAAT ATAACCAAAA TATTTTCACC AAAAATTTCG 3660 TTAAACATCC GAGATATTTG TTGTTTTTGC CGATCGAGCA AAGATTAGTA GTCCAGCAGT 3720 GTCTGCACCA CCACCATCGT GATAATGCAT CTTGTGTGTT ATTCTTGATG AGAAAATACG 3780 TAGTGAAAAC CACATATATG GTGGAAACTT GGAAACTACC GTTAGATCGA GAAATGGATG 3840 TCCAAGATCG TCCACGTCAC CAAGAGATAA AATTTAACTC GCAGATTCAC TTATGAGTTA 3900 AAATTTTAAT GAGAGTTAAA TTTTAACTCA TGTTGATGTG GACGAATATC GGACATCCAT 3960 TTCTCGATCC AACGATAGCT TCTAAGTTTC CACTACATAT GTGGTTTGCA CTATATATTT 4020 TCCCATTCTT GATTATGTGT TTGAGAGCAG CTAGCACAAA GAGAAAAAAA AGCATCGTTT 4080 TTCACGCGTA TGTTTTCAGA ACTGTTAAAT GGTGTGTTTT TTTAAAAAAC TTTATATAGA 4140 AAAGTTTCTT TAAAAAATAT ATTAATCTAT TTTTTAAGTT TAAAATAATT ACTACTTAAT 4200 TAATTATACA CTAACAGCTT ATTTCGTTCT ACGTATCTTG TCAATTTTCG CTATTCCTTT 4260 CTTCTCAAAC ACGGCATTGG ATGCTCTCAT AGCACTTGCT CGTTCGGATA GAAGACTTGA 4320 CGAAGACGAC CGCTACAACT TGGTGTGTTA TATCGTGCTT TGTTTAGCAT AATCATTACA 4380 TATATTCCAT GCCGAAGTGC CGACGATGAG ACCGTGTTCG ATGCATCTTT GTATGGCATC 4440 TAGGGACAAA GAGCATAGAG TCCCTACCAT AGTACCTGCT TGCGCAGAAG ACTTGACGAG 4500 AAGACCGACT GCTACACCTT GGTGTGTAAT AATATCGTGT TGTGTGTACC ATGCATACTC 4560 CTTTAAAACA AATAATGGTG GTAACAGTAA ATCTGTCATC CCACCCACTC TCATTGTAAA 4620 TTTTGCAAGT TATCACTTGA ACTTCTTAAT ACTCCATCCG TTTGCGTGTG TTCTTTCAGA 4680 ATTTGCGTGA GCACTTTTTC TTCTATATAA TCTGTCTAGT CCATGAGCTA AACCAACATC 4740 TCTCGCTGTC TTGCCTTGCA CTTCTGCACG ATG ATA TCA CTC CCA TTA TTG CTC 4794 Met Ile Ser Leu Pro Leu Leu Leu 1 5 TTC GTC CTG TTG TTC TCT GCG CTG CTG CTC TGC CCT TCA AGC AGT GAC 4842 Phe Val Leu Leu Phe Ser Ala Leu Leu Leu Cys Pro Ser Ser Ser Asp 10 15 20 GAC GAT GGT GAT GCT GCC GGC GAC GAA CTC GCG CTG CTC TCT TTC AAG 4890 Asp Asp Gly Asp Ala Ala Gly Asp Glu Leu Ala Leu Leu Ser Phe Lys 25 30 35 40 TCA TCC CTG CTA TAC CAG GGG GGC CAG TCG CTG GCA TCT TGG AAC ACG 4938 Ser Ser Leu Leu Tyr Gln Gly Gly Gln Ser Leu Ala Ser Trp Asn Thr 45 50 55 TCC GGC CAC GGC CAG CAC TGC ACA TGG GTG GGT GTT GTG TGC GGC CGC 4986 Ser Gly His Gly Gln His Cys Thr Trp Val Gly Val Val Cys Gly Arg 60 65 70 CGG CAC CCG CAC AGG GTG GTG AAG CTG CGG CTG CGC TCG TCC AAC CTG 5034 Arg His Pro His Arg Val Val Lys Leu Arg Leu Arg Ser Ser Asn Leu 75 80 85 ACC GGG ATC ATC TCG CCA TCG CTG GGC AAC CTA TCC TTC CTC AGG ACG 5082 Thr Gly Ile Ile Ser Pro Ser Leu Gly Asn Leu Ser Phe Leu Arg Thr 90 95 100 CTG CAA CTC AGC AAC AAC CAC CTG TCC GGC AAG ATA CCC CAG GAG CTC 5130 Leu Gln Leu Ser Asn Asn His Leu Ser Gly Lys Ile Pro Gln Glu Leu 105 110 115 120 AGC CGT CTC AGC AGG CTC CAG CAG CTG GTA CTG AAT TTC AAC AGC CTA 5178 Ser Arg Leu Ser Arg Leu Gln Gln Leu Val Leu Asn Phe Asn Ser Leu 125 130 135 TCG GGT GAG ATT CCA GCT GCT TTG GGC AAT CTA ACC AGT CTC TCA GTT 5226 Ser Gly Glu Ile Pro Ala Ala Leu Gly Asn Leu Thr Ser Leu Ser Val 140 145 150 CTT GAG CTG ACT AAC AAT ACA CTG TCT GGT TCT ATC CCT TCA TCC CTG 5274 Leu Glu Leu Thr Asn Asn Thr Leu Ser Gly Ser Ile Pro Ser Ser Leu 155 160 165 GGC AAG CTC ACC GGC CTC TAT AAT CTT GCA CTG GCT GAA AAT ATG CTG 5322 Gly Lys Leu Thr Gly Leu Tyr Asn Leu Ala Leu Ala Glu Asn Met Leu 170 175 180 TCT GGT TCC ATC CCT ACG TCT TTC GGC CAA TTG CGC AGA TTA TCT TTC 5370 Ser Gly Ser Ile Pro Thr Ser Phe Gly Gln Leu Arg Arg Leu Ser Phe 185 190 195 200 CTT AGC TTA GCC TTC AAC CAC TTA AGT GGA GCG ATC CCA GAT CCT ATT 5418 Leu Ser Leu Ala Phe Asn His Leu Ser Gly Ala Ile Pro Asp Pro Ile 205 210 215 TGG AAC ATC TCC TCT CTC ACC ATA TTT GAA GTC GTG TCC AAC AAC CTA 5466 Trp Asn Ile Ser Ser Leu Thr Ile Phe Glu Val Val Ser Asn Asn Leu 220 225 230 ACT GGT ACA CTG CCT GCA AAT GCA TTC AGT AAT CTT CCT AAT CTG CAG 5514 Thr Gly Thr Leu Pro Ala Asn Ala Phe Ser Asn Leu Pro Asn Leu Gln 235 240 245 CAG GTT TTC ATG TAC TAC AAC CAT TTT CAT GGT CCT ATC CCT GCA TCG 5562 Gln Val Phe Met Tyr Tyr Asn His Phe His Gly Pro Ile Pro Ala Ser 250 255 260 ATT GGT AAT GCT TCC AGC ATC TCA ATA TTT ACC ATT GGT TTA AAC TCT 5610 Ile Gly Asn Ala Ser Ser Ile Ser Ile Phe Thr Ile Gly Leu Asn Ser 265 270 275 280 TTT AGC GGT GTT GTT CCA CCG GAG ATT GGA AGG ATG AGA AAT CTT CAG 5658 Phe Ser Gly Val Val Pro Pro Glu Ile Gly Arg Met Arg Asn Leu Gln 285 290 295 AGA CTA GAG CTT CCA GAA ACT CTT TTG GAA GCT GAA GAA ACA AAT GAT 5706 Arg Leu Glu Leu Pro Glu Thr Leu Leu Glu Ala Glu Glu Thr Asn Asp 300 305 310 TGG AAA TTC ATG ACG GCA TTG ACA AAT TGC TCC AAT CTT CAA GAA GTG 5754 Trp Lys Phe Met Thr Ala Leu Thr Asn Cys Ser Asn Leu Gln Glu Val 315 320 325 GAA CTG GCA GGT TGC AAA TTT GGT GGA GTC CTC CCT GAT TCT GTT TCC 5802 Glu Leu Ala Gly Cys Lys Phe Gly Gly Val Leu Pro Asp Ser Val Ser 330 335 340 AAT CTT TCC TCT TCG CTT GTA TCT CTC TCC ATT AGA GAT AAC AAA ATT 5850 Asn Leu Ser Ser Ser Leu Val Ser Leu Ser Ile Arg Asp Asn Lys Ile 345 350 355 360 TCA GGG AGC TTA CCT AGA GAT ATC GGT AAT CTC GTT AAT TTA CAA TAT 5898 Ser Gly Ser Leu Pro Arg Asp Ile Gly Asn Leu Val Asn Leu Gln Tyr 365 370 375 CTT TCT CTC GCT AAC AAC TCC TTG ACA GGA TCC CTT CCC TCT TCC TTC 5946 Leu Ser Leu Ala Asn Asn Ser Leu Thr Gly Ser Leu Pro Ser Ser Phe 380 385 390 AGC AAG CTT AAA AAT TTA CGT CGT CTC ACT GTA GAT AAC AAC AGG TTA 5994 Ser Lys Leu Lys Asn Leu Arg Arg Leu Thr Val Asp Asn Asn Arg Leu 395 400 405 ATT GGT TCT CTC CCA TTG ACT ATC GGT AAT CTT ACA CAA CTA ACT AAT 6042 Ile Gly Ser Leu Pro Leu Thr Ile Gly Asn Leu Thr Gln Leu Thr Asn 410 415 420 ATG GAG GTC CAA TTT AAT GCC TTT GGT GGT ACA ATA CCA AGC ACA CTT 6090 Met Glu Val Gln Phe Asn Ala Phe Gly Gly Thr Ile Pro Ser Thr Leu 425 430 435 440 GGA AAC CTG ACC AAG CTG TTT CAA ATA AAT CTT GGC CAC AAT AAC TTT 6138 Gly Asn Leu Thr Lys Leu Phe Gln Ile Asn Leu Gly His Asn Asn Phe 445 450 455 ATA GGG CAA ATT CCC ATT GAA ATA TTT AGC ATT CCC GCA CTC TCT GAA 6186 Ile Gly Gln Ile Pro Ile Glu Ile Phe Ser Ile Pro Ala Leu Ser Glu 460 465 470 ATT TTG GAT GTG TCC CAT AAT AAC TTG GAG GGA TCA ATA CCA AAA GAA 6234 Ile Leu Asp Val Ser His Asn Asn Leu Glu Gly Ser Ile Pro Lys Glu 475 480 485 ATA GGG AAA CTT AAA AAT ATT GTC GAA TTC CAT GCT GAT TCG AAC AAA 6282 Ile Gly Lys Leu Lys Asn Ile Val Glu Phe His Ala Asp Ser Asn Lys 490 495 500 TTA TCG GGT GAG ATC CCT AGC ACC ATT GGT GAA TGC CAA CTT CTG CAG 6330 Leu Ser Gly Glu Ile Pro Ser Thr Ile Gly Glu Cys Gln Leu Leu Gln 505 510 515 520 CAT CTT TTC CTG CAA AAC AAT TTC TTA AAT GGT AGC ATC CCA ATA GCT 6378 His Leu Phe Leu Gln Asn Asn Phe Leu Asn Gly Ser Ile Pro Ile Ala 525 530 535 CTG ACT CAG TTG AAA GGT CTG GAC ACA CTT GAT CTC TCA GGC AAC AAT 6426 Leu Thr Gln Leu Lys Gly Leu Asp Thr Leu Asp Leu Ser Gly Asn Asn 540 545 550 TTG TCA GGT CAG ATA CCT ATG TCC TTA GGG GAC ATG ACT CTG CTC CAC 6474 Leu Ser Gly Gln Ile Pro Met Ser Leu Gly Asp Met Thr Leu Leu His 555 560 565 TCG CTG AAC CTT TCG TTC AAC AGC TTC CAC GGT GAA GTG CCA ACC AAT 6522 Ser Leu Asn Leu Ser Phe Asn Ser Phe His Gly Glu Val Pro Thr Asn 570 575 580 GGT GTT TTT GCA AAT GCT TCT GAA ATT TAC ATC CAA GGC AAT GCC CAT 6570 Gly Val Phe Ala Asn Ala Ser Glu Ile Tyr Ile Gln Gly Asn Ala His 585 590 595 600 ATT TGC GGT GGC ATA CCT GAA CTA CAT CTT CCG ACG TGT TCC TTA AAA 6618 Ile Cys Gly Gly Ile Pro Glu Leu His Leu Pro Thr Cys Ser Leu Lys 605 610 615 TCA AGA AAG AAA AGG AAA CAT CAA ATT CTG CTG TTA GTG GTT GTT ATC 6666 Ser Arg Lys Lys Arg Lys His Gln Ile Leu Leu Leu Val Val Val Ile 620 625 630 TGT CTC GTT TCG ACA CTT GCC GTC TTT TCG TTA CTC TAC ATG CTT CTA 6714 Cys Leu Val Ser Thr Leu Ala Val Phe Ser Leu Leu Tyr Met Leu Leu 635 640 645 ACC TGT CAT AAG AGA AGA AAG AAA GAA GTC CCT GCA ACG ACA TCC ATG 6762 Thr Cys His Lys Arg Arg Lys Lys Glu Val Pro Ala Thr Thr Ser Met 650 655 660 CAA GGC CAC CCA ATG ATC ACT TAC AAG CAG CTG GTA AAA GCA ACG GAT 6810 Gln Gly His Pro Met Ile Thr Tyr Lys Gln Leu Val Lys Ala Thr Asp 665 670 675 680 GGT TTT TCG TCC AGC CAT TTG TTG GGT TCT GGA TCT TTT GGC TCT GTT 6858 Gly Phe Ser Ser Ser His Leu Leu Gly Ser Gly Ser Phe Gly Ser Val 685 690 695 TAC AAA GGA GAA TTT GAT AGT CAA GAT GGT GAA ATC ACA AGT CTT GTT 6906 Tyr Lys Gly Glu Phe Asp Ser Gln Asp Gly Glu Ile Thr Ser Leu Val 700 705 710 GCC GTG AAG GTA CTA AAG CTA GAA ACT CCT AAG GCA CTC AAG AGT TTC 6954 Ala Val Lys Val Leu Lys Leu Glu Thr Pro Lys Ala Leu Lys Ser Phe 715 720 725 ACG GCC GAA TGC GAA ACA CTA CGA AAT ACG CGA CAC CGG AAT CTT GTC 7002 Thr Ala Glu Cys Glu Thr Leu Arg Asn Thr Arg His Arg Asn Leu Val 730 735 740 AAG ATA GTT ACG ATT TGC TCG AGC ATC GAT AAC AGA GGG AAT GAT TTC 7050 Lys Ile Val Thr Ile Cys Ser Ser Ile Asp Asn Arg Gly Asn Asp Phe 745 750 755 760 AAA GCA ATT GTG TAT GAC TTC ATG CCC AAT GGC AGT CTG GAA GAT TGG 7098 Lys Ala Ile Val Tyr Asp Phe Met Pro Asn Gly Ser Leu Glu Asp Trp 765 770 775 CTA CAC CCT GAA ACA AAT GAT CAA GCA GAG CAA AGG CAC TTG ACT CTG 7146 Leu His Pro Glu Thr Asn Asp Gln Ala Glu Gln Arg His Leu Thr Leu 780 785 790 CAT CAG AGA GTG ACC ATA CTA CTT GAT GTT GCA TGT GCA TTG GAG CAT 7194 His Gln Arg Val Thr Ile Leu Leu Asp Val Ala Cys Ala Leu Glu His 795 800 805 CTT CAC TTC CAT GGC CCT GAA CCT ATT GTA CAC TGT GAT ATT AAA TCA 7242 Leu His Phe His Gly Pro Glu Pro Ile Val His Cys Asp Ile Lys Ser 810 815 820 AGC AAT GTG TTG TTA GAT GCT GAT ATG GTA GCT CAT GTT GGA GAC TTT 7290 Ser Asn Val Leu Leu Asp Ala Asp Met Val Ala His Val Gly Asp Phe 825 830 835 840 GGA CTT GCA AGA ATA CTT GTT GAG GGA AGC TCA TTG ATG CAA CAG TCA 7338 Gly Leu Ala Arg Ile Leu Val Glu Gly Ser Ser Leu Met Gln Gln Ser 845 850 855 ACA AGT TCG ATG GGA ATC AGG GGG ACA ATT GGT TAC GCA GCA CCA G 7384 Thr Ser Ser Met Gly Ile Arg Gly Thr Ile Gly Tyr Ala Ala Pro 860 865 870 GTTAATCCTA AACTGTTTAT GTCTACCTCC TTTCATTGTT TTTTTTTTAG ATTTGCTCTG 7444 GTCCAACAAA AAATACCTAA AGATACAGAT ACTTGTACCT CACAGTACTA AATAGTTTTT 7504 GATCATTGCA TTGTTAGATC CAACGATCAG AAAACGATTT GGTACCGTGA CCGTGAGGTA 7564 TCGGAATCTC GAGATATTTT TTTGTTCGAC CGTAGCAAAT CTATTTTTTT GTTTGTTTTC 7624 TTCTCTTTAA TGTTTTATGA CTATGAAATA ATTTTTATTT CTGGAAAACA G AG TAT 7680 Glu Tyr GGT GTC GGG AAC ACT GCC TCG ACA CAT GGA GAT ATT TAC AGT TAT GGA 7728 Gly Val Gly Asn Thr Ala Ser Thr His Gly Asp Ile Tyr Ser Tyr Gly 875 880 885 ATT CTA GTG TTG GAA ACA GTA ACC GGG ATG CGG CCG GCA GAC AGT ACA 7776 Ile Leu Val Leu Glu Thr Val Thr Gly Met Arg Pro Ala Asp Ser Thr 890 895 900 905 TTC AGA ACT GGA TTG AGC CTC CGT CAG TAC GTT GAA CCG GGT CTA CAT 7824 Phe Arg Thr Gly Leu Ser Leu Arg Gln Tyr Val Glu Pro Gly Leu His 910 915 920 GGT AGA CTA ATG GAT GTT GTT GAC AGG AAG CTT GGT TTG GAT TCC GAG 7872 Gly Arg Leu Met Asp Val Val Asp Arg Lys Leu Gly Leu Asp Ser Glu 925 930 935 AAA TGG CTT CAG GCT CGA GAT GTT TCG CCA CGC AGC AGT ATT ACT GAA 7920 Lys Trp Leu Gln Ala Arg Asp Val Ser Pro Arg Ser Ser Ile Thr Glu 940 945 950 TGC CTT GTT TCA CTG CTT AGA CTT GGG CTG TCT TGC TCT CAG GAA TTG 7968 Cys Leu Val Ser Leu Leu Arg Leu Gly Leu Ser Cys Ser Gln Glu Leu 955 960 965 CCA TCG AGT AGA ACG CAA GCC GGA GAT GTC ATC AAT GAA CTG CGT GCC 8016 Pro Ser Ser Arg Thr Gln Ala Gly Asp Val Ile Asn Glu Leu Arg Ala 970 975 980 985 ATC AAA GAG TCT CTC TCG ATG TCA TCC GAC ATG TGAAGATGTG AGACATGCTG 8069 Ile Lys Glu Ser Leu Ser Met Ser Ser Asp Met 990 995 ATGTTATGTT GGAGTATTTC GTTGTAATGT AATGTGAAGG GTGAGTGTGT GACTGCTTGG 8129 TTGTAAGCTA TTTCCTGATC TGCCCATCAG ATCATGTATC TGTTCTATTG TTGTATTTCT 8189 CAGAACAACC ACACACCTAA GTAGGAGTAC ACAATAGTGT ATTTGTGTGA TTTCAATATT 8249 GGTGCATACC CATGCTATGT GAACAGTCAA TCGGGGAGCG ATTCACACCA TACCGTGAAA 8309 TCGACCTAAT CAGCTAATCT AATTCTACAG GCTGCCTTTG CATGACAGTG TGATATTAAA 8369 TTAGCCCAGC CCTTTTTAGC AAACGATGGG AGGGTCAATG CTCTAGA 8416 (2) INFORMATION FOR SEQ ID NO:5: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 996 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:5: Met Ile Ser Leu Pro Leu Leu Leu Phe Val Leu Leu Phe Ser Ala Leu 1 5 10 15 Leu Leu Cys Pro Ser Ser Ser Asp Asp Asp Gly Asp Ala Ala Gly Asp 20 25 30 Glu Leu Ala Leu Leu Ser Phe Lys Ser Ser Leu Leu Tyr Gln Gly Gly 35 40 45 Gln Ser Leu Ala Ser Trp Asn Thr Ser Gly His Gly Gln His Cys Thr 50 55 60 Trp Val Gly Val Val Cys Gly Arg Arg His Pro His Arg Val Val Lys 65 70 75 80 Leu Arg Leu Arg Ser Ser Asn Leu Thr Gly Ile Ile Ser Pro Ser Leu 85 90 95 Gly Asn Leu Ser Phe Leu Arg Thr Leu Gln Leu Ser Asn Asn His Leu 100 105 110 Ser Gly Lys Ile Pro Gln Glu Leu Ser Arg Leu Ser Arg Leu Gln Gln 115 120 125 Leu Val Leu Asn Phe Asn Ser Leu Ser Gly Glu Ile Pro Ala Ala Leu 130 135 140 Gly Asn Leu Thr Ser Leu Ser Val Leu Glu Leu Thr Asn Asn Thr Leu 145 150 155 160 Ser Gly Ser Ile Pro Ser Ser Leu Gly Lys Leu Thr Gly Leu Tyr Asn 165 170 175 Leu Ala Leu Ala Glu Asn Met Leu Ser Gly Ser Ile Pro Thr Ser Phe 180 185 190 Gly Gln Leu Arg Arg Leu Ser Phe Leu Ser Leu Ala Phe Asn His Leu 195 200 205 Ser Gly Ala Ile Pro Asp Pro Ile Trp Asn Ile Ser Ser Leu Thr Ile 210 215 220 Phe Glu Val Val Ser Asn Asn Leu Thr Gly Thr Leu Pro Ala Asn Ala 225 230 235 240 Phe Ser Asn Leu Pro Asn Leu Gln Gln Val Phe Met Tyr Tyr Asn His 245 250 255 Phe His Gly Pro Ile Pro Ala Ser Ile Gly Asn Ala Ser Ser Ile Ser 260 265 270 Ile Phe Thr Ile Gly Leu Asn Ser Phe Ser Gly Val Val Pro Pro Glu 275 280 285 Ile Gly Arg Met Arg Asn Leu Gln Arg Leu Glu Leu Pro Glu Thr Leu 290 295 300 Leu Glu Ala Glu Glu Thr Asn Asp Trp Lys Phe Met Thr Ala Leu Thr 305 310 315 320 Asn Cys Ser Asn Leu Gln Glu Val Glu Leu Ala Gly Cys Lys Phe Gly 325 330 335 Gly Val Leu Pro Asp Ser Val Ser Asn Leu Ser Ser Ser Leu Val Ser 340 345 350 Leu Ser Ile Arg Asp Asn Lys Ile Ser Gly Ser Leu Pro Arg Asp Ile 355 360 365 Gly Asn Leu Val Asn Leu Gln Tyr Leu Ser Leu Ala Asn Asn Ser Leu 370 375 380 Thr Gly Ser Leu Pro Ser Ser Phe Ser Lys Leu Lys Asn Leu Arg Arg 385 390 395 400 Leu Thr Val Asp Asn Asn Arg Leu Ile Gly Ser Leu Pro Leu Thr Ile 405 410 415 Gly Asn Leu Thr Gln Leu Thr Asn Met Glu Val Gln Phe Asn Ala Phe 420 425 430 Gly Gly Thr Ile Pro Ser Thr Leu Gly Asn Leu Thr Lys Leu Phe Gln 435 440 445 Ile Asn Leu Gly His Asn Asn Phe Ile Gly Gln Ile Pro Ile Glu Ile 450 455 460 Phe Ser Ile Pro Ala Leu Ser Glu Ile Leu Asp Val Ser His Asn Asn 465 470 475 480 Leu Glu Gly Ser Ile Pro Lys Glu Ile Gly Lys Leu Lys Asn Ile Val 485 490 495 Glu Phe His Ala Asp Ser Asn Lys Leu Ser Gly Glu Ile Pro Ser Thr 500 505 510 Ile Gly Glu Cys Gln Leu Leu Gln His Leu Phe Leu Gln Asn Asn Phe 515 520 525 Leu Asn Gly Ser Ile Pro Ile Ala Leu Thr Gln Leu Lys Gly Leu Asp 530 535 540 Thr Leu Asp Leu Ser Gly Asn Asn Leu Ser Gly Gln Ile Pro Met Ser 545 550 555 560 Leu Gly Asp Met Thr Leu Leu His Ser Leu Asn Leu Ser Phe Asn Ser 565 570 575 Phe His Gly Glu Val Pro Thr Asn Gly Val Phe Ala Asn Ala Ser Glu 580 585 590 Ile Tyr Ile Gln Gly Asn Ala His Ile Cys Gly Gly Ile Pro Glu Leu 595 600 605 His Leu Pro Thr Cys Ser Leu Lys Ser Arg Lys Lys Arg Lys His Gln 610 615 620 Ile Leu Leu Leu Val Val Val Ile Cys Leu Val Ser Thr Leu Ala Val 625 630 635 640 Phe Ser Leu Leu Tyr Met Leu Leu Thr Cys His Lys Arg Arg Lys Lys 645 650 655 Glu Val Pro Ala Thr Thr Ser Met Gln Gly His Pro Met Ile Thr Tyr 660 665 670 Lys Gln Leu Val Lys Ala Thr Asp Gly Phe Ser Ser Ser His Leu Leu 675 680 685 Gly Ser Gly Ser Phe Gly Ser Val Tyr Lys Gly Glu Phe Asp Ser Gln 690 695 700 Asp Gly Glu Ile Thr Ser Leu Val Ala Val Lys Val Leu Lys Leu Glu 705 710 715 720 Thr Pro Lys Ala Leu Lys Ser Phe Thr Ala Glu Cys Glu Thr Leu Arg 725 730 735 Asn Thr Arg His Arg Asn Leu Val Lys Ile Val Thr Ile Cys Ser Ser 740 745 750 Ile Asp Asn Arg Gly Asn Asp Phe Lys Ala Ile Val Tyr Asp Phe Met 755 760 765 Pro Asn Gly Ser Leu Glu Asp Trp Leu His Pro Glu Thr Asn Asp Gln 770 775 780 Ala Glu Gln Arg His Leu Thr Leu His Gln Arg Val Thr Ile Leu Leu 785 790 795 800 Asp Val Ala Cys Ala Leu Glu His Leu His Phe His Gly Pro Glu Pro 805 810 815 Ile Val His Cys Asp Ile Lys Ser Ser Asn Val Leu Leu Asp Ala Asp 820 825 830 Met Val Ala His Val Gly Asp Phe Gly Leu Ala Arg Ile Leu Val Glu 835 840 845 Gly Ser Ser Leu Met Gln Gln Ser Thr Ser Ser Met Gly Ile Arg Gly 850 855 860 Thr Ile Gly Tyr Ala Ala Pro Glu Tyr Gly Val Gly Asn Thr Ala Ser 865 870 875 880 Thr His Gly Asp Ile Tyr Ser Tyr Gly Ile Leu Val Leu Glu Thr Val 885 890 895 Thr Gly Met Arg Pro Ala Asp Ser Thr Phe Arg Thr Gly Leu Ser Leu 900 905 910 Arg Gln Tyr Val Glu Pro Gly Leu His Gly Arg Leu Met Asp Val Val 915 920 925 Asp Arg Lys Leu Gly Leu Asp Ser Glu Lys Trp Leu Gln Ala Arg Asp 930 935 940 Val Ser Pro Arg Ser Ser Ile Thr Glu Cys Leu Val Ser Leu Leu Arg 945 950 955 960 Leu Gly Leu Ser Cys Ser Gln Glu Leu Pro Ser Ser Arg Thr Gln Ala 965 970 975 Gly Asp Val Ile Asn Glu Leu Arg Ala Ile Lys Glu Ser Leu Ser Met 980 985 990 Ser Ser Asp Met 995 (2) INFORMATION FOR SEQ ID NO:6: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 19639 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (vi) ORIGINAL SOURCE: (A) ORGANISM: Oryza longistaminata (B) STRAIN: IRBB21 (viii) POSITION IN GENOME: (A) CHROMOSOME/SEGMENT: 11 (B) MAP POSITION: 11q, RG103 (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 5213..18201 (D) OTHER INFORMATION: /note= “Xa21 gene” (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: join(5213..7889, 8732..9132) (D) OTHER INFORMATION: /product= “receptor kinase-like protein” /note= “Xa21 disease resistance gene” (ix) FEATURE: (A) NAME/KEY: misc_feature (B) LOCATION: 9645..9769 (D) OTHER INFORMATION: /note= “Pop-Ol1, transposon-like element” (ix) FEATURE: (A) NAME/KEY: misc_feature (B) LOCATION: 13040..13248 (D) OTHER INFORMATION: /note= “Ds-rice1, transposon-like element” (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: join(15118..17720, 17827..18204) (D) OTHER INFORMATION: /product= “receptor kinase-like protein” /note= “Xa21 gene family member C; 2 bp deletion causing frame-shift mutation of ORF compared to family member A1” (ix) FEATURE: (A) NAME/KEY: misc_feature (B) LOCATION: 16183..16184 (D) OTHER INFORMATION: /note= “location of 2 bp deletion compared to family member A1” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6: AAGCTTTGCT CATTTCTTCT CCAATTACAA TTAATCGTGT GTGCATCAAG TAATTAATTA 60 AGAAACTCTG GCTTGTTGAA AGGTCGCAGT GACAATTAAT CGTGAGTGCA TAGGATGGGG 120 AAAACACGAG GGATCGGTCG ACCATCGGGG GGAGCAAAAA TCAAGCGCTC CCCCGCCCCA 180 CGACGCGCAC ATGCCACGCC ACCCCACCAC GCACCACGTG TGCCGTTGTA AACACCTGCC 240 ACGTGTCCCC ATCACATACT CCGTTGTAAC AAATCACCCA TATATTTTGG AAACCCTATA 300 TTAGGAGAAT TCGTTTCATT TTTTTTCTAC CAAAAATATT TCACCTAGTG TACTCACAAT 360 GTTTCACTAT GTATAGATCT AATTTTGTAG TAAATTGAAA CATTCTTTTG CAATAAATTA 420 CCCATATATT ATGGAAACCC TCTATTAAGG GAATTCGTTT CATTTTTTAT TCCACTAAAA 480 ATGTTTCGCC TAGTGTACTT GTAATGTTTC ACTATGTATG GATTAAATGT TGCAGTGACT 540 TGAAACATTC TTTCGCTATT TGCTGAAACA TTGTTTTTAT ATAAGGTGAA ACAGCGCCCG 600 ATTTAAACGA TTGAAATATT TTCGATCTAC TTAGTGAAAC AATTCCAATA TACTTGGTGC 660 AACAACGTGC AACATTTAAT TATAATTCCA TAATAAGCTT GTCGACATTT GATAGTCACG 720 ACTAGGGTAT TTGGATGGTA TGGGGATCAT CGGTACCAGG GTATATGCGA GATTGAGGTA 780 AAAGAGATGG AGATAGGGAT TTTTATATAG GTTCGGGCCC CTTATCTGAT AGGTAATAGC 840 CCTACATCCT GTTTATATGT GATTGATATA GAAAAACCAC AGAATACAAC AATTGGGATA 900 ACCTATCTAG CCGTTGTTGA CTTGGCGGCA CGAACACCAA CTCGTAGTCG ACGACGGGGA 960 AGCCTTTCTC CTCGATTGTG AACTCGACAA GATTAGAGAT ATCGCTAGAT CCCTCTTGCC 1020 GGCCTCTGTA GGTACCGGAT GGGGTGTGTC TAGGCTAATC TCAGATGTCG ATGTTTGGCG 1080 GCGTATTGGC TTGTGTCTTG TGGCTTCTAT GTTGTGTGTC CCCTCTCCTC CAATGGAGGC 1140 TTGGATTTAG ACTCATAGAT TTCCCCTTGT CCAAGTAGAA CTAGGGAGAC CAATATAGAT 1200 ACAATCCGAG TAGTACTTGT CGTTTCTATA TAGAACTCTA TTTTGTCCTT CCTTATCCGG 1260 AACTCCTTCT ATATATGAGG TATGTTTCCG TATAAGACTT GGTATGTGGT GGGCCTCGCC 1320 GAGCTTAGTC GATTACTATT GGGTATGTGG TATCCTAGGC CCCAGCTGCC ATTTTCCACA 1380 AAGACAGCTT GAATCTTATA ACAAACCTTG CTGAAGCTGA CAAATCCTAG CCCCCAGCCA 1440 TGAAGTTGGA AAAATCAATT TCCGATTACA CAAATTGGTT AATACGCAAC CATTTAGTGC 1500 TCTTAACATG ACCAGGTTTT ACATGTTCAT TCGGCTCTTA GAATCTGACA AGACCTTATC 1560 TGCTCTGGGC GTCCCCAGCC GAAATTCCAT TAGTTTTCTC GGAGGCTTGT CAGAACAGCG 1620 TAAAGGGACA ATAGGACTGC CTTCAAGATG AGGCGATATA AGAGGGGATC AACAGACAAA 1680 TATTGCACAT ATAAAACTTA CAGAAGTTGA TGTAGATGAT GAGACGACCA CCACACTAGG 1740 CAAAGACCAG GTGTATAGTT GTACTCAACA AATCGCAGAG GTAGTGAGAG ATCGCTACGA 1800 TCTACTGGTC GAAGATCAGG TGTAGGCGTA TTCTCGATCA CCTGAAGAAG AATCTTTAGG 1860 TGTTGAGAGA TCGCTACTAT CTACTGGTCA ACACTAGTAA AAAAACCTCA TAGAGATCGG 1920 CACTATAGGT GCCGAACAGC TAAAACCCGC ACCTATATAC TTTCCTCTCG TGGACTCAAA 1980 GCACGTAAAC CGACACTTTA GCAACTATAG GTGCGGTCTA AAGAGACCGA CACTATAGTA 2040 TAGTGCTGGT TTTAAAAAAC CCGACACTTT AATATAATAT AGTGTCGGTC TCTTTAAAAC 2100 GACACAATAT AAATATACGT GTCGGTTTTT AATAAACGGC ACCTATCAAA CCGAGCCTAG 2160 CTGTCGAGTC GAGCCAATCC AGGTGACGCA TATATTAGTC TCGTCCTTAT CGCCTCCGGT 2220 CTCTCTCTCT CTCTCTCTCT CTCTTTCTCT CTCGCCTCTC TGTGTAGCGC GCGGCGGTGG 2280 TCGGGCAGCG TCCCGGCGTA GGCAACAGTG GTGGCGAGAT GGGAGGCGGT GGCGCATCAC 2340 AGCTATTCAC TTTAGCGCCT TGAATAATAA TCGGCATCAT GATCTACTTA TGCTTCGTGC 2400 AAGAGGGAAG AATGTAGATA CACATGGTCA CAGCTAAGTG CTATGATCGC GGCTCATCTC 2460 TCCAAATAGA TTCATGCCAT CCGTACTTAA ACAGAACCTT ATGTTCCGTG CATCCTTTCT 2520 GAAGTCTTGA AATGTTTTAT CGATGTTTTA CCACTACGAC CCATCTGTAG GGTGTCTCGC 2580 ATCCCGTCTT GTTTATGTTT TTATGTGTGC CAGCGCACCA TTCTAGCACG CGCTTTGTTC 2640 CTGAACAAAC ACCTTAGCCG TGGTATTAAA TGGAAATACT GCATGATCAT AGCAGGAACT 2700 CTCTTCTTCG AAGGATGTCC GTCAACATCA CCTAGGTCAT CTCGTCTAAT CTTATATCGT 2760 AGTGCCTTAC AAACCAGGCG TGCTTCTAGG TTCTCGTACT CCTCCACGCG ATAGAGGATA 2820 CAATCATTCA GACATACGTG TATCTTCTGT ACTTCCAGTC CGAGAGGGCA GATTACCTTT 2880 TTAGCTTCGT ACGTTGTTTC GAGCAATTCG TTTCCCTCGG GAAGAATATT CTTTACGAGT 2940 TTCAATAACT CGCCAAATGC CTTGTCAGTC ACACCATATT TTGCCTTCCA TTGTCAGAAT 3000 TCCAGTGTGG TACCCAACTT TTTGTGCTCC TATTCGCAAC CTGGGTACAA GGACGTTTTG 3060 TGGTATGCTA ACATCCGGTC CAATTTCTAG ACCAACTTTT TCACTTTTGC AGTCATTTTT 3120 TACATCGCAC AACATTTGAC CAAGATTATC CGTACCGCCG TTTTCTTCAA CAGCTCTGTC 3180 CGCCTCGCCT ATTGTATTTT CTGCAAATCC ATCATATTGA GCCCAGTCTG AAATGTTGTC 3240 GTCTTCTTAT TAATTTTCTT CTATTGCAAC CCCTAACTCT CCGTGCAAGG TCTAACAATT 3300 ATAGCCAGGT ATGAATCCCG ATTCCAACAA GTGGATATGA AGACTTCTTA GATGTAGAAT 3360 ACTCCTTCTG GTTTTTGCAC TTTTGCATGG ACAACATATA AAACCCTTAG GCTTGTGGGC 3420 ATTGGCCACA CTCAAAAAAT AATGCACGTC ATCAATAAAC TCCTTCGACC GTCGTTCTGC 3480 AGTGTACATC CATTACCGAT TCATCTACAT TAGGAGATAA TAATTGTAAA GGAAGTCCAC 3540 AAAAGTGAAA CTACTTAAAT AATCATATAA TAATTTAAAA TATCATAATT AAATTGAAAA 3600 CTGACGGTTT TAATGTATTC TTCTTATTTC TAACGATTTT AACGAGTTTT AAATGGACTT 3660 AATCGGAGTC ATGATTAACT ATTTATAAAT TTTATCTGTC TCAATAAATT GTAAATATAT 3720 TTTTCCATGT ATTATCCTTG TTTAATTATT TTTAAAAGTT CTAAACATAT TTTTAATGCA 3780 TTCTACTTAT TTCTAACTAT TTTAAAGATT TTCAAATGGA CTTAGTTTTC TATTTTTATT 3840 CTTCATTTTC TATATTTGCC CTTTGTTGTC TCTTTTTAAC AATTTTATAC AAATATTTAT 3900 AATTTTATTA AGTACCCTAA TTTTCCCTAA ACAATTTTTC TCTCTCATCG TATTTCCATA 3960 TATCTTTTTG AGATAATAAT GGATATAAAC ATAGCTAGAA ATGTAAATGT TCACCTTGCA 4020 TCAATAGGGG ATGAAGTTGC TAACCTTTTA GATCTCCTCG ATTTGTATAA TATAACCAAA 4080 ATATTTTCAC CAAAAATTTC GTTAAACATC CGAGATATTT GTTGTTTTTG CCGATCGAGC 4140 AAAGATTAGT AGTCCAGCAG TGTCTGCACC ACCACCATCG TGATAATGCA TCTTGTGTGT 4200 TATTCTTGAT GAGAAAATAC GTAGTGAAAA CCACATATGT GGTGGAAACT TAGAAACTAC 4260 CGTTAGATCG AGAAATGGAT GTCCAAGATT CGTCCACGTC ACCAAGAGAT AAAATTTAGC 4320 TCGCAGATTC ACTTATGAGT TAAAATTTTA ATGAGAGTTA AATTTTAACT CATGTTGATG 4380 TGGACGAATA TCGGACATCC ATTTCTCGAT CCAACGATAG CTTCCAAGTT TCCACTACAT 4440 ATGTGGTTTG CACTATATAT TTTCCCATTC TTGATTATGT GTTTGAGAGC AGCTAGCACA 4500 AAGAGAAAAA AAAGCATCGT TTTTCACGCG TATGTTTTCA GAACTGTTAA ATGGTGTGTT 4560 TTTTGAAAAA ACTTTCTATA GAAAAGTTTC TTTAAAAAAT ATATTAATCT ATTTTTTAAG 4620 TTTAAAATAA TTACTACTTA ATTAATTATA CACTAACAGC TTATTTCGTT CTACGTATCT 4680 TGTCAATTTT CGCTATTCCT TTCTTCTCAA ACACGGCATT GGATGCTCTC ATAGCACTTG 4740 CTCGTTCGGA TAGAAGACTT GACGAAGACG ACCGCTACAA CTTGGTGTGT TATATCGTGC 4800 TTTGTTTAGC ATAATCATTA CATATATTCC ATGCCGAAGT GCCGACGATG AGACCGTGTT 4860 CGATGCATCT TTGTATGGCA TCTAGGGACA AAGAGCATAG AGTCCCTACC ATAGTACCAG 4920 CTCGCGCAGA AGACTTGACG AGAAGACCGA CTGCTACACC TTGGTGTGTA ATAATATCGT 4980 GTTGTGTGTA CCATGCATAC TCCTTTAAAA CAAATAATGG TGGTAACAGT AAATCTGTCA 5040 TCCCACCCAC TCTCATTGTA AATTTTGCAA GTTCTCACTT GAACTTCTTA ATACTCCATC 5100 CGTTTGCGTG TGTTCTTTCA GAATTTGCGT GAGCACTTTT TCTTCTATAT AATCTGTCTA 5160 GTCCATGAGC TAAACCAACA TCTCTCGCTG TCTTGCCTTG CACTTCTGCA CG ATG 5215 Met 1 ATA TCA CTC CCA TTA TTG CTC TTC GTC CTG TTG TTC TCT GCG CTG CTG 5263 Ile Ser Leu Pro Leu Leu Leu Phe Val Leu Leu Phe Ser Ala Leu Leu 5 10 15 CTC TGC CCT TCA AGC AGT GAC GAC GAT GGT GAT GCT GCC GGC GAC GAA 5311 Leu Cys Pro Ser Ser Ser Asp Asp Asp Gly Asp Ala Ala Gly Asp Glu 20 25 30 CTC GCG CTG CTC TCT TTC AAG TCA TCC CTG CTA TAC CAG GGG GGC CAG 5359 Leu Ala Leu Leu Ser Phe Lys Ser Ser Leu Leu Tyr Gln Gly Gly Gln 35 40 45 TCG CTG GCA TCT TGG AAC ACG TCC GGC CAC GGC CAG CAC TGC ACA TGG 5407 Ser Leu Ala Ser Trp Asn Thr Ser Gly His Gly Gln His Cys Thr Trp 50 55 60 65 GTG GGT GTT GTG TGC GGC CGC CGC CGC CGC CGG CAC CCA CAC AGG GTG 5455 Val Gly Val Val Cys Gly Arg Arg Arg Arg Arg His Pro His Arg Val 70 75 80 GTG AAG CTG CTG CTG CGC TCC TCC AAC CTG TCC GGG ATC ATC TCG CCG 5503 Val Lys Leu Leu Leu Arg Ser Ser Asn Leu Ser Gly Ile Ile Ser Pro 85 90 95 TCG CTC GGC AAC CTG TCC TTC CTC AGG GAG CTG GAC CTC GGC GAC AAC 5551 Ser Leu Gly Asn Leu Ser Phe Leu Arg Glu Leu Asp Leu Gly Asp Asn 100 105 110 TAC CTC TCC GGC GAG ATA CCA CCG GAG CTC AGC CGT CTC AGC AGG CTT 5599 Tyr Leu Ser Gly Glu Ile Pro Pro Glu Leu Ser Arg Leu Ser Arg Leu 115 120 125 CAG CTG CTG GAG CTG AGC GAT AAC TCC ATC CAA GGG AGC ATC CCC GCG 5647 Gln Leu Leu Glu Leu Ser Asp Asn Ser Ile Gln Gly Ser Ile Pro Ala 130 135 140 145 GCC ATT GGA GCA TGC ACC AAG TTG ACA TCG CTA GAC CTC AGC CAC AAC 5695 Ala Ile Gly Ala Cys Thr Lys Leu Thr Ser Leu Asp Leu Ser His Asn 150 155 160 CAA CTG CGA GGT ATG ATC CCA CGT GAG ATT GGT GCC AGC TTG AAA CAT 5743 Gln Leu Arg Gly Met Ile Pro Arg Glu Ile Gly Ala Ser Leu Lys His 165 170 175 CTC TCG AAT TTG TAC CTT TAC AAA AAT GGT TTG TCA GGA GAG ATT CCA 5791 Leu Ser Asn Leu Tyr Leu Tyr Lys Asn Gly Leu Ser Gly Glu Ile Pro 180 185 190 TCC GCT TTG GGC AAT CTC ACT AGC CTC CAG GAG TTT GAT TTG AGC TTC 5839 Ser Ala Leu Gly Asn Leu Thr Ser Leu Gln Glu Phe Asp Leu Ser Phe 195 200 205 AAC AGA TTA TCA GGA GCT ATA CCT TCA TCA CTG GGG CAG CTC AGC AGT 5887 Asn Arg Leu Ser Gly Ala Ile Pro Ser Ser Leu Gly Gln Leu Ser Ser 210 215 220 225 CTA TTG ACT ATG AAT TTG GGA CAG AAC AAT CTA AGT GGG ATG ATC CCC 5935 Leu Leu Thr Met Asn Leu Gly Gln Asn Asn Leu Ser Gly Met Ile Pro 230 235 240 AAT TCT ATC TGG AAC CTT TCG TCT CTA AGA GCG TTT AGT GTC AGA GAA 5983 Asn Ser Ile Trp Asn Leu Ser Ser Leu Arg Ala Phe Ser Val Arg Glu 245 250 255 AAC AAG CTA GGT GGT ATG ATC CCT ACA AAT GCA TTC AAA ACC CTT CAC 6031 Asn Lys Leu Gly Gly Met Ile Pro Thr Asn Ala Phe Lys Thr Leu His 260 265 270 CTC CTC GAG GTG ATA GAT ATG GGC ACT AAC CGT TTC CAT GGC AAA ATC 6079 Leu Leu Glu Val Ile Asp Met Gly Thr Asn Arg Phe His Gly Lys Ile 275 280 285 CCT GCC TCA GTT GCT AAT GCT TCT CAT TTG ACA GTG ATT CAG ATT TAT 6127 Pro Ala Ser Val Ala Asn Ala Ser His Leu Thr Val Ile Gln Ile Tyr 290 295 300 305 GGC AAC TTG TTC AGT GGA ATT ATC ACC TCG GGG TTT GGA AGG TTA AGA 6175 Gly Asn Leu Phe Ser Gly Ile Ile Thr Ser Gly Phe Gly Arg Leu Arg 310 315 320 AAT CTC ACA GAA CTG TAT CTC TGG AGA AAT TTG TTT CAA ACT AGA GAA 6223 Asn Leu Thr Glu Leu Tyr Leu Trp Arg Asn Leu Phe Gln Thr Arg Glu 325 330 335 CAA GAT GAT TGG GGG TTC ATT TCT GAC CTA ACA AAT TGC TCC AAA TTA 6271 Gln Asp Asp Trp Gly Phe Ile Ser Asp Leu Thr Asn Cys Ser Lys Leu 340 345 350 CAA ACA TTG AAC TTG GGA GAA AAT AAC CTG GGG GGA GTT CTT CCT AAT 6319 Gln Thr Leu Asn Leu Gly Glu Asn Asn Leu Gly Gly Val Leu Pro Asn 355 360 365 TCG TTT TCC AAT CTT TCC ACT TCG CTT AGT TTT CTT GCA CTT GAA TTG 6367 Ser Phe Ser Asn Leu Ser Thr Ser Leu Ser Phe Leu Ala Leu Glu Leu 370 375 380 385 AAT AAG ATC ACA GGA AGC ATT CCG AAG GAT ATT GGC AAT CTT ATT GGC 6415 Asn Lys Ile Thr Gly Ser Ile Pro Lys Asp Ile Gly Asn Leu Ile Gly 390 395 400 TTA CAA CAT CTC TAT CTC TGC AAC AAC AAT TTC AGA GGG TCT CTT CCA 6463 Leu Gln His Leu Tyr Leu Cys Asn Asn Asn Phe Arg Gly Ser Leu Pro 405 410 415 TCA TCG TTG GGC AGG CTT AAA AAC TTA GGC ATT CTA CTC GCC TAC GAA 6511 Ser Ser Leu Gly Arg Leu Lys Asn Leu Gly Ile Leu Leu Ala Tyr Glu 420 425 430 AAC AAC TTG AGC GGT TCG ATC CCG TTG GCC ATA GGA AAT CTT ACT GAA 6559 Asn Asn Leu Ser Gly Ser Ile Pro Leu Ala Ile Gly Asn Leu Thr Glu 435 440 445 CTT AAT ATC TTA CTG CTC GGC ACC AAC AAA TTC AGT GGT TGG ATA CCA 6607 Leu Asn Ile Leu Leu Leu Gly Thr Asn Lys Phe Ser Gly Trp Ile Pro 450 455 460 465 TAC ACA CTC TCA AAC CTC ACA AAC TTG TTG TCA TTA GGC CTT TCA ACT 6655 Tyr Thr Leu Ser Asn Leu Thr Asn Leu Leu Ser Leu Gly Leu Ser Thr 470 475 480 AAT AAC CTT AGT GGT CCA ATA CCC AGT GAA TTA TTC AAT ATT CAA ACA 6703 Asn Asn Leu Ser Gly Pro Ile Pro Ser Glu Leu Phe Asn Ile Gln Thr 485 490 495 CTA TCA ATA ATG ATC AAT GTA TCA AAA AAT AAC TTG GAG GGA TCA ATA 6751 Leu Ser Ile Met Ile Asn Val Ser Lys Asn Asn Leu Glu Gly Ser Ile 500 505 510 CCA CAA GAA ATA GGG CAT CTC AAA AAT CTA GTA GAA TTT CAT GCA GAA 6799 Pro Gln Glu Ile Gly His Leu Lys Asn Leu Val Glu Phe His Ala Glu 515 520 525 TCG AAT AGA TTA TCA GGT AAA ATC CCT AAC ACG CTT GGT GAT TGC CAG 6847 Ser Asn Arg Leu Ser Gly Lys Ile Pro Asn Thr Leu Gly Asp Cys Gln 530 535 540 545 CTC TTA CGG TAT CTT TAT CTG CAA AAT AAT TTG TTA TCT GGT AGC ATC 6895 Leu Leu Arg Tyr Leu Tyr Leu Gln Asn Asn Leu Leu Ser Gly Ser Ile 550 555 560 CCA TCA GCC TTG GGT CAG CTG AAA GGT CTC GAA ACT CTT GAT CTC TCA 6943 Pro Ser Ala Leu Gly Gln Leu Lys Gly Leu Glu Thr Leu Asp Leu Ser 565 570 575 AGC AAC AAT TTG TCA GGC CAG ATA CCC ACA TCC TTA GCA GAT ATT ACT 6991 Ser Asn Asn Leu Ser Gly Gln Ile Pro Thr Ser Leu Ala Asp Ile Thr 580 585 590 ATG CTT CAT TCC TTG AAC CTT TCT TTC AAC AGC TTT GTG GGG GAA GTG 7039 Met Leu His Ser Leu Asn Leu Ser Phe Asn Ser Phe Val Gly Glu Val 595 600 605 CCA ACC ATT GGT GCT TTC GCA GCT GCA TCC GGG ATC TCA ATC CAA GGC 7087 Pro Thr Ile Gly Ala Phe Ala Ala Ala Ser Gly Ile Ser Ile Gln Gly 610 615 620 625 AAT GCC AAA CTC TGT GGT GGA ATA CCT GAT CTA CAT CTG CCT CGA TGT 7135 Asn Ala Lys Leu Cys Gly Gly Ile Pro Asp Leu His Leu Pro Arg Cys 630 635 640 TGT CCA TTA CTA GAG AAC AGA AAA CAT TTC CCA GTT CTA CCT ATT TCT 7183 Cys Pro Leu Leu Glu Asn Arg Lys His Phe Pro Val Leu Pro Ile Ser 645 650 655 GTT TCT CTG GCC GCA GCA CTG GCC ATC CTC TCA TCA CTC TAC TTG CTT 7231 Val Ser Leu Ala Ala Ala Leu Ala Ile Leu Ser Ser Leu Tyr Leu Leu 660 665 670 ATA ACC TGG CAC AAG AGA ACT AAA AAG GGA GCC CCT TCA AGA ACT TCC 7279 Ile Thr Trp His Lys Arg Thr Lys Lys Gly Ala Pro Ser Arg Thr Ser 675 680 685 ATG AAA GGC CAC CCA TTG GTC TCT TAT TCG CAG TTG GTA AAA GCA ACA 7327 Met Lys Gly His Pro Leu Val Ser Tyr Ser Gln Leu Val Lys Ala Thr 690 695 700 705 GAT GGT TTC GCG CCG ACC AAT TTG TTG GGT TCT GGA TCA TTT GGC TCA 7375 Asp Gly Phe Ala Pro Thr Asn Leu Leu Gly Ser Gly Ser Phe Gly Ser 710 715 720 GTA TAC AAA GGA AAG CTT AAT ATC CAA GAT CAT GTT GCA GTG AAG GTA 7423 Val Tyr Lys Gly Lys Leu Asn Ile Gln Asp His Val Ala Val Lys Val 725 730 735 CTA AAG CTT GAA AAT CCT AAG GCG CTC AAG AGT TTC ACT GCC GAA TGT 7471 Leu Lys Leu Glu Asn Pro Lys Ala Leu Lys Ser Phe Thr Ala Glu Cys 740 745 750 GAA GCA CTA CGA AAT ATG CGA CAT CGA AAT CTT GTC AAG ATA GTT ACA 7519 Glu Ala Leu Arg Asn Met Arg His Arg Asn Leu Val Lys Ile Val Thr 755 760 765 ATT TGC TCG AGC ATT GAT AAC AGA GGG AAC GAT TTC AAA GCA ATT GTG 7567 Ile Cys Ser Ser Ile Asp Asn Arg Gly Asn Asp Phe Lys Ala Ile Val 770 775 780 785 TAT GAC TTC ATG CCC AAC GGC AGT CTG GAA GAT TGG ATA CAC CCT GAA 7615 Tyr Asp Phe Met Pro Asn Gly Ser Leu Glu Asp Trp Ile His Pro Glu 790 795 800 ACA AAT GAT CAA GCA GAC CAG AGG CAC TTG AAT CTG CAT CGA AGA GTG 7663 Thr Asn Asp Gln Ala Asp Gln Arg His Leu Asn Leu His Arg Arg Val 805 810 815 ACC ATA CTA CTT GAT GTT GCC TGC GCA CTG GAC TAT CTT CAC CGC CAT 7711 Thr Ile Leu Leu Asp Val Ala Cys Ala Leu Asp Tyr Leu His Arg His 820 825 830 GGC CCT GAA CCT GTT GTA CAC TGT GAT ATT AAA TCA AGC AAT GTG CTG 7759 Gly Pro Glu Pro Val Val His Cys Asp Ile Lys Ser Ser Asn Val Leu 835 840 845 TTA GAT TCT GAT ATG GTA GCC CAT GTT GGA GAT TTT GGG CTT GCA AGA 7807 Leu Asp Ser Asp Met Val Ala His Val Gly Asp Phe Gly Leu Ala Arg 850 855 860 865 ATA CTT GTT GAT GGG ACC TCA TTG ATA CAA CAG TCA ACA AGC TCG ATG 7855 Ile Leu Val Asp Gly Thr Ser Leu Ile Gln Gln Ser Thr Ser Ser Met 870 875 880 GGA TTT ATA GGG ACA ATT GGC TAT GCA GCA CCA G GTCAGCAAGT 7899 Gly Phe Ile Gly Thr Ile Gly Tyr Ala Ala Pro 885 890 CCTTCCAGTA TTTTGCATTT TCTGATCTCT AGTGCTATAT GAAATAGTTT TTACCTCTAG 7959 TGAAACTGAT GGAGAATATA AGTAATTAAT TGAACTAATT AAATTGCACA AAAATAAGAT 8019 TATTTGCCAT ATCTATTCAG ATGCTAAATA TAGCTAGTTC ATAGAGGTAC AGATTTTTTT 8079 ATATAGGACT CTAGAGCTAC CACACACTCA AATCAAATTA TGGGTGTTTT CTGCTCTACA 8139 CTGCAATATG AAATGATTAT TACTTCTACA TGAACTGATG GAGGAGTTTC AGAAGGATCA 8199 AATTTGAGTA AATTTTTCAA TTCTACATTT AAGAAACACT TTTTTTTCAT ATGCTAGTTA 8259 CATTTTTTTA TTTCACGAGC TTACATTGAC CATGAAAAAT ACTTGGCACT ACTTACTAAT 8319 TCCCACATGG AGGTAGTGAA AATAATATAG ATACAAAAAC GAAATATCCT ATGTTGTGTG 8379 ATATACTATA ATCACAATGA ACACAAACAG GATTCGTACA AAAGTAATTA GCCATCATAG 8439 CAACTGATTG CTTGGGGTAA CTGTATAGCA CAATCATACC AAATTTCTTT AGATATGTAT 8499 CTGTAAATTA GATTCTTAAA GTTAAATATG AAATTTCATT GGTATTTATG TTTCTTTATA 8559 TAATAAAAAT TAATCCAGCC TTTGCATCTA TCATTTGTCC AGACATCCTT GTTATTTGTG 8619 ATATTTAACA CGTAAATTTA CATAATTATA CATCCAAGTT CTTTTTATTT AACACTGTAA 8679 ATTTCAAATC GTACATGTTA TAAAGAATGT ACTATATTTC CTGCTCAAAC AG AG 8733 Glu TAT GGC GTT GGG CTC ATT GCA TCA ACG CAT GGA GAT ATT TAC AGC TAT 8781 Tyr Gly Val Gly Leu Ile Ala Ser Thr His Gly Asp Ile Tyr Ser Tyr 895 900 905 GGA ATT CTA GTG CTG GAA ATA GTA ACC GGG AAG CGG CCA ACT GAC AGT 8829 Gly Ile Leu Val Leu Glu Ile Val Thr Gly Lys Arg Pro Thr Asp Ser 910 915 920 925 ACA TTC AGA CCC GAT TTG GGC CTC CGT CAG TAC GTT GAA CTG GGC CTA 8877 Thr Phe Arg Pro Asp Leu Gly Leu Arg Gln Tyr Val Glu Leu Gly Leu 930 935 940 CAT GGC AGA GTG ACG GAT GTT GTT GAC ACG AAG CTC ATT TTG GAT TCT 8925 His Gly Arg Val Thr Asp Val Val Asp Thr Lys Leu Ile Leu Asp Ser 945 950 955 GAG AAC TGG CTG AAC AGT ACA AAT AAT TCT CCA TGT AGA AGA ATC ACT 8973 Glu Asn Trp Leu Asn Ser Thr Asn Asn Ser Pro Cys Arg Arg Ile Thr 960 965 970 GAA TGC ATT GTT TGG CTG CTT AGA CTT GGG TTG TCT TGC TCT CAG GAA 9021 Glu Cys Ile Val Trp Leu Leu Arg Leu Gly Leu Ser Cys Ser Gln Glu 975 980 985 TTG CCA TCG AGT AGA ACG CCA ACC GGA GAT ATC ATC GAC GAA CTG AAT 9069 Leu Pro Ser Ser Arg Thr Pro Thr Gly Asp Ile Ile Asp Glu Leu Asn 990 995 1000 1005 GCC ATC AAA CAG AAT CTC TCC GGA TTG TTT CCA GTG TGT GAA GGT GGG 9117 Ala Ile Lys Gln Asn Leu Ser Gly Leu Phe Pro Val Cys Glu Gly Gly 1010 1015 1020 AGC CTT GAA TTC TGATGTTATG TCTCGTAATG TTTTATTGCC ACACTTCAGA 9169 Ser Leu Glu Phe 1025 TCGACTTCTG CAGTGGTATC TACCACACGA TCACTAAAGT CACCGTGGCT ATTTCCTGAT 9229 CCAGCATATC TGATCATGCA TGTTCTGTGT TGTATACCTG TATTTTACTC TGAATTGCCA 9289 CACCGCAACC CTGCCTCTGT TTGTTTGGTA TACAAAAGAT AGTGATGAGT TTATTGTTTT 9349 AGGGGCTTCC TAGTTGGCGC GTGTGCATGC CGGCATGCAC GCAGCCCGAG GGTGGGTTTC 9409 TTTTTTTTCC ATTGTTATTC CGTTGCTTTT TTTCACCACG GTAGATTTTT TTTTCCGGAT 9469 TTCCATTTTT TCCGTTGTTT TTCTCTATCG CTTATGTTGG CGGATTTTTT TCCGTGGTTT 9529 TCTTTCCGAA GACGAGTATA TCTAACGTAA CTAACATGTT ACTTTTAGAT AACGATGGTT 9589 ATTAAGATAA GATTTTTCTC TGGAAGATTT TTGTAAGTAA CAGATTGAAA ACAAATCTAT 9649 ACGTGAGGTC AAATTTTGAA AACTTTCAAT CTAGATTTAA AAGCTTTTCA ACTCAAAATT 9709 TGAATTTTTG AAGTGAAAAT TTGAATACTT TCAAAAATTA CTAGTAATCG ACAAAAAAAA 9769 TATGGAAATG GAAACGGAAA TAGTTTTGCT GTTATACCGA TCGTTTCCAT ATTTACCGTA 9829 TTCTTATAGA AATTACCGTT TCTTATAATA TGGTAATTAC CGTATTTCTA AATATGTTGA 9889 TATTTATAGG GCATGTCTCT ACTTGACTCA CAGTTTAGAG ATTGATTGAC TATTTAATCA 9949 AATCCCTAAC TTGATTGCAT GGCTAAAATG GAGTTGATTT CTAATTTATA TAGTATAGCT 10009 TGAATTTATT TGTAAATATA ACATACTTAT GTAAAGTTAA ATATATGTTT TCTATAGTTT 10069 AATGTTTCTG TATTTGTTAC CGGTTTTCGA TCTGTACCGA CATATTTCCA TCAGTATTAT 10129 TCCATTTCCG GTTTTCCGAT ATTTCCGATA TCGTTTTCGT TTCCGACTTT ACCGTTTTCG 10189 ATTTCATTTC CGAGAAAAAT ATGATTATGG AAATGGTCGA GGCTGTTTTC CGATCGTTTC 10249 CGACCGTTTT CATCCCTACC CGTAGTAATA ATATATAACA TTTTATCTCT AATCTTTCTC 10309 TCTCTCATAT CAATGAATAA TCGCTAAGAG ACTGCTATTA ACAAGGCTTA TATATATATA 10369 TGCCGTCGAT CAGTCATTTT GAAACGGCCC ACTTCTTTTC CATCTATATG CATTCATGAA 10429 ATACATGGTA TATCCCATCG ATCGGACATC ACCTGTTAGC GCGTACGCCA TCGTCGTCAT 10489 CAACCTAGCT AGGGCAAACG CACCTTGCTG AGCTCCGATC CTCCGATCGC CACCATCACC 10549 AATGAACAAG CTGCTGCGGC CTCTCGGTGG CCTGAGGTTG CTCAACCGAG AAGAACATCC 10609 GTTCCGATGC TTCTCCTCCT CCATCGATCT CGTCTTCCCA GGTCGCCGCC GCCGCCACAT 10669 GGCAACCACC GTGACCCACC CGCCGCCGAC GGAATCCGCT GGTTCGACGG CGGCGGCCGC 10729 GACTGCTGAC CCGGCCTCGG TGATGCTGGA ACATTGGGGC TGCCTCAGGG GCTCCACGCC 10789 GGCGAACGTA GTCGCCGACG ACAACACCGC CGCGGAGTCC CGCACCTCCC GCGGCCAACC 10849 CCTCCGGGTC GCCCTCGCCC GCGCGTCGCC GCCGGCGATC TCCTTCATCT GCTTCGATCG 10909 CGGGGATGAT GGCTACGTCA TCGCGGCTCA CGGCGACTCT GTCCTCTTCC GGATGAGTTG 10969 GAACGACTAC TTCGTCTACA TGGCCGCCGG CGGCCGCCGT CGCTGACGCT GCTCCCCGTC 11029 TGCGACATCC CCATGAACGA GCGCTGCTGG GTCAGCAAGG ACCGTTTCAA GGACAGCTTC 11089 CACACCACGG GCCGGGAGTT CGACCAGCAG GACACCGGCA TCCTGCGCCT CCGCGGCGAC 11149 GACGGCGGCG AGGAGGCGCC GCTCTAGTGG CGCAGTCCAG ATCGCGCACG AGCCGCCGTT 11209 CGACACGGCC GAGCTCTGCG TGCTCCGCCC CGGCCACGGC GAGTGGGAGC TCAAGATGGC 11269 GGTGCCCATC GTCCACCATG ACAGCTTGAA TCTTATAACA AACCTTGCTG AAGCTGACAA 11329 ATCCTAGCCC CCAGCCATGA AGTTGGAAAA ATCAATTTCC GATTACACAA ATTGGTTAAT 11389 ACGCAACCAT TTAGTGCTCT TAACATGACC AGGTTTTACA TGTTCGTTCG GCTCTTAGAA 11449 TCTGACAATA CCTTATCTGC TCTGGGCGTC CCCAGCCGAA ATTCCATTAG TTTTCTCGGA 11509 GGCTTGTCAG AACAGCGTAA AGGGACAATA GGACTGCCTT CAAGATGAGG CGATATAAGA 11569 CGGGATCAAC AGACAAATAT TGCACATATA AATACTTACA GAAGTTGATG TAGATGATGA 11629 GACGACCACC ACACTAGGCA AAGACCAGGT GTATAGTTGT ACTCAACAAA TCGCAGAGGT 11689 AGTGAGAGAT CGCTACGATC TACTGGTCAA AGATCAGGTG TAGGCGTATT CTCGATCACC 11749 TGAAGAAGAA TCTCTAGGTG TTGAGAGATC GCTACTATCT ACTGGTCAAA ACTAGTAAAA 11809 AAACCTCATA GAGATCGGCA CTATAGGTGC CGAACAGCTA AAACCCGCAC CTATATACTT 11869 TCCTCTCGTG GACTCAAAGC ACGTAAACCG ACACTTTAGC AACTATAGGT GCGGTCTAAA 11929 GAGACCGACA CTATAGTATA GTGCTGGTTT TAAAAAACCT GACACTTTAA TATAATATAG 11989 TGTCGGTCTC TTTAAAACGA CACAATATAA ATATACGTGT CGGTTTTAAT AAACGGCACC 12049 TATCAAACGA TCCTAGCTGT CGAGTCGAGC CAATCCAGGT GACGCATATA TTAGTCTCGT 12109 CCTTATCGCC TCATCTCTCT CTCTCTCTCT CTCTCTCTCT TTCTCTCTCG CCTCTCTGTG 12169 TAGCGCGCGG CGGTGGTCGG GCGGCATCCC GGCGTAGGCA ACAGTGGTGG CGAGATGGGA 12229 GGCGGTGGCG CATCACAGCT ATTCACTTTA GCGCCTTGAA TAATAATCGG CATCATGATC 12289 TACTTATGCT TCGTGCAAGG GGGAAGATTG TAGATACACA TGGTCACAGC TAAGTGCTAT 12349 GATCGCGGCT CATCTCTCCA AATAGATTCA TGCCATCCGT ACTTAAACAG AACCTTATGT 12409 TCCGTGCATC CTTTCTGAAG TCTTGAAATG TTTTATCGAT GTTTTACCAC TACGACCCAT 12469 CTGTAGGGTG TCTCGCATCC CGTCTTGTTT ATGTTTTTAT GTGTGCCAGC GCACCATTCT 12529 AGCACGCGCT TTGTTCCTGA ACAAACACCT TAGCCGTGGT ATTAAATGGA AATACTGCAT 12589 GATCATAGCA GGAACTCTCT TCTTCGAAGG ATGTCCGTCA ACATCACCTA GGTCATCTCG 12649 TCTAATCTTA TATCGTAGTG CCTTACAAAC CAGGCGTGCT TCTAGGTTCT CGTACTCCTC 12709 AACGCGATAG AGGATACAAT CATTCAGACA TACGTGTATC TTCTGTACTT CCAGTCTGAG 12769 AGGGCAGATT ACCATTTTAG CTTCGTACGT TGTTTCGAGC AATTCGTTTC CCTCGGGAAG 12829 AATATTCTTT ACGAGTTTCA ATAACTCGCC AAATGCCTTG TCAGTCACAC CATATTTTGC 12889 CTTCCATTGT CAGAATTCCA GTGTGGTACC CAACTTTTTG TGCTCCTATT CGCAACCTGG 12949 GTACAAGGAC GTTTTGTGGT ATGCTAACAT CCGGTCCAAT TTCTAGACCA ACTTTTTCAC 13009 TTTTGCAGTC ATTTTTTACA TCGCACAACA TTTGACCAAG ATTATCCGTA CCGCCGTTTT 13069 CTTCAACAGC TCTGTCCGCC TCGCCTATTG TATTTTCTGC AAATCCATCA TATTGAGCCC 13129 AGTCTGAAAT GTTGTCGTCT TCTTATTCAT TTTCTTCTAT TGCAACCCCT AACTCTCCGT 13189 GCAAGGTCTA ACAATTATAG CCAGGTATGA ATCCCGATTC CAACAAGTGG ATATGAAGAC 13249 TTCTTAGATG TAGAATACTC CTTCTGGTTT TTGCACTTTT GCATGGACAA CATATAAAAC 13309 CCTTAGGCTT GTGGGCATTG GCCACACTCA AAAAATAATG CACGTCATCA ATAAACTCCT 13369 TCGACCGTCG TTCTGCAGTG TACATCCATT GCCGATTCAT CTACATTAGG AGATAATAAT 13429 TGTAAAGGAA GTCCACAAAA GTGAAACTAC TTAAATAATC ATATAATAAT TTAAAATATC 13489 ATAATTAAAT TGAAAACTGA CGGTTTTAAT GTATTCTTCT TATTTCTAAC GATTTTAACG 13549 AGTTTTAAAT GGACTTAATC GGAGTCATGA TTAACTATTT ATAAATTTTA TCTGTCTCAA 13609 TAAATTGTAA ATATATTTCT CCATGTATTA TCCTTGTTTA GTTATTTTTA AAAGTTCTAA 13669 ACATATTTTT AATGCATTAT ACTTATTTCT AACTATTTTA AAGATTTTCA AATGGACTTA 13729 GTTTTCTATT TTTATTCTTC ATTTTGTATA TTTGCCCTTT GTTGTCTCTT TTTAACAATT 13789 TTATACAAAT ATTTATAATT TTATTAAGTA CCCTCATTTT CCCTAAACAA TTTTTCTCTC 13849 TCATCGTATT TCCATATATC TTTTTGAGAT AATAATGGAT ATAAACATAG CTAGAAATGT 13909 AAATGTTCAC CTTGCATCAA TAGGGGATGA AGTTGCTAAC CTTTTAGATC TCCTCGATTT 13969 GTATAATATA ACCAAAATAT TTTCACCAAA AATTTCGTTA AACATCCGAG ATATTTGTTG 14029 TTTTTGCCGA TCGAGCAAAG ATTAGTAGTC CAGCAGTGTC TGCACCACCA CCATCGTGAT 14089 AATGCATCTT GTGTGTTATT CTTGATGAGA AAATACGTAG TGAAAACCAC ATATGTGGTG 14149 GAAACTTGGA AACTACCGTT AGATCGAGAA ATGGATGTCC AAGATTCGTC CACATCACCA 14209 AGAGATAAAA TTTAACTCGC AGATTCACTT ATGAGTTAAA ATTTTAATGA GAGTTAAATT 14269 TTAACTCATG TTGATGTGGA CGAATATCGG ACATCCATTT CTCGATCCAA CGATAGCTTC 14329 CAAGTTTCCA CTACATATGT GGTTTGCACT ATATATTTTC CCATTCTTGA TTATGTGTTT 14389 GAGAGCAGCT AGCACAAAGA GAAAAAAAAG CATCGTTTTT CACGCGTATG TTTTCAGAAC 14449 TGTTAGATGG TGTGTTTTTT GAAAAAACTT TCTATAGAAA AGTTTCTTTA AAAAATATAT 14509 TAATCTATTT TTTAAGTTTA AAATAATTAC TACTTAATTA ATTATACACT AACAGCTTAT 14569 TTCGTTCTAC GTATCTTGTC AATTTTCGCT CATCCTTTCT TCTCAAACAC GGCATTGGAT 14629 GCTCTCATAG CACTTGCTCG TTCGGATAGA AGACTTGACG AAGACGACCG CTACAACTTG 14689 GTGTGTTATA TCGTGCTTTG TTTAGCATAA TCATTACATA TATTCCATGC CGAAGTGCCG 14749 ACGAGGAGAC CGTGTTCGAT GCATCTTTGT ATGGCATCTA GGGACAAAGA GCATAGAGTC 14809 CCTACCATAG TACCTGCTCG CGCAGAAGAC TTGACGAGAA GACCGACTGC TACACCTTGG 14869 TGTGTAATAA TATCGTGTTG TGTGTACCAT GCATACTCCT TTAAAACAAA TAATGGTGGT 14929 AACAGTAAAT CTGTCATCCC ACCCACTCTC ATTGTAAATT TTGCAAGTTA TCACTTGAAC 14989 TTCTTAATAC TCCATCCGTT TGCGTGTGTT CTTTCAGAAT TTGCGTGAGC ACTTTTTCTT 15049 CTATATAATC TGTCTAGTCC ATGAGCTAAA CCAACATCTC TCGCTGTCTT GCCTTGCACT 15109 TCTGCACGAT GGTATCACTC CCATTATTGC TCTTCGTCCT GTTGTTCTCT GCGCTGCTGC 15169 TCTGCCCTTC AAGCAGTGAC GACGATGGTG ATGCTGCCGG CGGCGAACTC GCGCTGCTCT 15229 CTTTCAAGTC ATCCCTGCTA TACCAGGGGG GCCAGTCGCT GGCATCTTGG AACACGTCCG 15289 GCCACAGCCA ACACTGCACA TGGGTGGGTG TTGTGTGCGG CCGCCGGCAC CCGCACAGGG 15349 TGGTGAAGCT GCGGCTGCGC TCGTCCAACC TGACCGGGAT CATCTCGCCG TCGCTGGGCA 15409 ACCTATCCTT CCTCAGGACG CTGCAACTCA GCAACAACCA CCTGTCCGGC AAGATACCCC 15469 AGGAGCTCAG CCGTCTCAGC AGGCTCCAGC AACTGGTACT GAATTTCAAC AGCCTATCGG 15529 GTGAGATTCC AGCTGCTTTG GGCAATCTAA CCAGTCTCTC GGTTCTTGTG CTGACTAACA 15589 ATACACTGTC TGGTTCTATC CCTTCATCCC TGGGCAAGCT CACCGGCCTC TATAATCTTG 15649 CACTGGCTGA AAATATGCTG TCTGGTTCCA TCCCTTCATC TTTCGGCCAA TTGCGCAGAT 15709 TATCTTTCCT TAGCTTAGCC TTCAACCACT TAAGTGGAGC AATCCCAGAT CCTATTTGGA 15769 ACATCTCCTC TCTCACCATA TTTGAGGTCA TATCCAACAA GCTAAATGGT ACACTGCCTA 15829 CAAATGCATT CAGTAATCTT CCTAGTCTGA AGGAGGTATA CATGTATTAC AACCAGTTTC 15889 ATGGTCATAT CCCGGCATCG ATAGGTAATG CTTCCAACAT CTCAATATTT ACCATTGGTT 15949 TAAACTCCTT TAGCGGTGTT GTTCCACTGG AGATTGGAAG GCTGAGAAAT CTTCAGAGGC 16009 TAGAGCTTGG AGAAACTCTT CTAGAATCTA AAGAACCAAA CGATTGGAAA TTCATGATGG 16069 CATTGACGAA TTGCTCCAAT CTTCAAGAAG TAGAATTGGG ACTTTGTAAA TTTGGTGGAG 16129 TCATTCCTGA TTCTGTTTCC AATCTTTCCT CTTCCCTATT ATATCTCTTT TTTCGATAAC 16189 ATAATTTCAG GGAGCTTACC TAAGGATATC GGTAATCTCG TTAATTTAGA AACTCTTTCT 16249 CTCGCTAACA ACTCCTTGAC AGGATCCCTT CCCTCATCCT TCAGCAAGCT TAAAAATTTA 16309 CATCGTCTCA AACTTTTTAA CAACAAAATA AGTGGTTCTC TCCCATTAAC CATTGGTAAT 16369 CTTACACAAC TAACTAATAT GGAGCTCCAC TTTAATGCCT TCGGTGGTAC AATACCAGGC 16429 ACACTTGGAA ACCTGACCAA GTTGTTTCAA ATAAATCTTG GCCATAATAA CTTTATAGGT 16489 CAAATTCCCA TTGAAATATT TAGCATTCCT GCACTCTCTG AAATTTTGGA TGTGTCTCAT 16549 AATAACTTGG AGGGATCAAT ACCAAAAGAA ATAGGGAAAC TTAAAAATAT TGTCGAATTC 16609 CATGCTGATT CGAACAAATT ATCGGGTGAG ATCCCTAGCA CCATTGGTGA ATGCCAACTT 16669 CTGCAGCATC TTTTCCTGCA AAACAATTTC TTAAATGGTA GCATCCCAAT AGCTCTGACT 16729 CAGTTGAAAG GTCTGGACAC ACTTGATCTC TCAGGTAAGA ATTTGTCAGG TCAGATACCT 16789 ATGTCCTTAG GGGACATGCC TCTGCTCCAC TCGCTGAACC ATTCGTTCAA CAGCTTCCAC 16849 GGTGAAGTGC CAACCAATGG TGTTTTTGCA AATGCTTCTG AAATTTACAT CCAAGGCAAT 16909 GCCCATATTT GCGGTGGCAT ACCTGAACTA CATCTTCCGA CGTGTTCCTT AAAATCAAGA 16969 AAGAAAAAGA AACATCAAAT TCTGCTGTTA GTGGTTGTTA TCTGTCTCGT TTGGACACTT 17029 GCCGTCTTTT CGTTACTCTA CATGCTTCTA ACCGGCCATA AGAGAAGAAA GAAAGAAGTC 17089 CCTACAACGA CATCCATGCG AGGCCACCCA ATGATCACTT ACAAGCAGCT GGTAAAAGCA 17149 GCAGATGGTT GTTCGTCCAG CCATTTGCTG GGCTCTGGAT CCTTTGGCTC TGTTTTCAAA 17209 GGAGAATTTG ATAGCCAAGA TTGTGAAAGC ACAAGTCTTG TTGCCGTGAA GGTACTAAAG 17269 CTGGAAACTC CTAAGGCACT CAAGAGTTTC ATGGCCGAAT GCGAAACACT GCGAAATACT 17329 CGACACGTCA AGATAGTTAC AATTTGCTCG AGCATCGATA ACAGAGGGAA TGATTTCAAA 17389 GCAATTGTGT ATGACTTCAT GCCCAATGGC AGTCTGGAAG ATTGGCTACA CCCTGAAACA 17449 AATGATCAAG CAGAGCAAAG GCACTTGACT CTGCATCAGA GAGTGACCAT ACTGCTTGAT 17509 GTTGCATGTG CATTGGACCA TCTTCACTTC CATGGCCCTG AACCTATTGT ACACTGTGAT 17569 ATTAAATCAA GCAATGTGTT GTTAGATGCT GATATGGTAG CCCATGTTGG AGACTTTGGA 17629 CTCGCAAGAA TACTTATTGA GGGAAGCTCA TTGATGCAAC AGTCAACAAG TTCGATGGTA 17689 ATCAGGGGGA CAATTGGTTA CGCAGCACCA GGTTAAGCCT AAACTGTTTA TGTCTACCTC 17749 ATTTCATTTC TTCTTTTTTG TGTTTTCTTC TCTCTAGTGT TTTATGACTA TGAAATAATT 17809 TTTGCTACTG GAAAACAGAG TATGGTGTCG GGAACACTGC CTCGACACAT GGAGATATTT 17869 ACAGTTATGG AATTCTAGTG TTGGAAACAG TAACCGGGAA GCGGCCGACA GATAGTACAT 17929 TCAGAACTGG ATTGAGCCTC CGTCAGTACG TTGAACCGGG TCTACATGGT AGACTAATGG 17989 ATGTTGTTGA CAGGAAGCTT GGTTTGGATT CCGAGAAATG GCTTCAGGCT CGAGATATTT 18049 CGCCATGCAG CAGTATTAGT GAATGCCTTG TTTCACTGCT TAGACTTGGG TTGTCTTGCT 18109 CTCAGGAATT GCCATCGAGT AGAATGCAAG CCGGAGATGT CATCAATGAA CTGCGTGCCA 18169 TCAAAGAGTC CCTCTCGATG TCATCCGGCA TGTGAAGATG TTGGAGTATT TCGTTGTAAT 18229 GTGATGTGTC TATTAGTACC CTTCACAACT GATTTCATTC TGCCGTGGTA TTTAGTTATT 18289 TACAAGAGAG TCACTGAAGG GTGAGTGTGT GACTGCTTGG CTGTAGCTAT TTCCTGATCT 18349 GCCCATCAGA TCATGTATCT GTTCTATTGT TGTATTTCTC AGAATAACCA CACACCTAAG 18409 TACACAACAC TGTATTTGTG TGATTTCAAT ATTGATGCAT ATATACCCAT GCTATATGCT 18469 AGAATTATAT ACAAAAATTT TGAGATGTCT GAAGTTAACA ATCAATCAGG AAGCGATTCA 18529 CACCAAACCG CGAAATCGAC CTAATCAGCT AATCTAATTG TACATGCTGC CTTTGCATGA 18589 CAGTGCGATA TTAAATTAGC CCAGCCCTTT TTAGCAAAGG ATTGGAGGGT TAATGTTCTA 18649 GAGAAAAGGA TGCTTGTTAG GTTCTCTCTT CTCTCTCGGT TCTCTTGTTA GATTATGGAA 18709 CCAATTGATT TCCTCTCGAA CCAATCGATT TCGCCACCGT CGCCACCAGG TTCCAAATCG 18769 ATATTCCGGC GAGATGCCGT TACAGCGTTT TATAGACGCA ACTCACGCCT AGACTTTCTT 18829 CTCGGTACAG AACGGCCAAG CCCAAGACAT TCCACGGCCC ATTTAGGCCC CTTGTATTTA 18889 GTGTTGCTTT TACTAATGCG CTTCTCGCTT GCCTTGGCAT AATCTGGAAC TCCGCCTTCG 18949 ATCTGTAGCC CGTCTTCTTC CTTGTCGTCC TTGAGGTTCT CAGTCGCAGC ACCCAGCACC 19009 CTAAACAGAT GCCTTTGGTT AGGAAACATG GGTGGCAGCA ACCTTTCCAT GTTGGAATAT 19069 CTCGAAATCT CCTACACAGA TTTATTTTGC TAGGTGAAAT ACCTTCTCAC CTTGGTAATT 19129 AACATTTCAA ATTTGTGCCA CCTTAATCTC AGTGGCACAT ATATGTACAC AATAGATATC 19189 TCTTGGTTAG CTCATCAACA TTTGCTTGAA TATCTCGACA TGACTTTTAT AAATCTAAGG 19249 GTACGTTCAG TCATCTCCGA CACGCAAAAC GAAGCACCAT TCGCGCATGA TTAATCAAAT 19309 ATTAGCTAAA AAATTATAAA ATGGATTAAT ATATTTTTTA AAAGCCACGC TCCTATAATA 19369 TTTTTTAAAA AATACATAGT TTAACAGTTT GAAAAGCGTG TCGTACGGAA AACGGGAGAG 19429 GTGAAGTTGG CAAAGTAGAC TTTAGAACAC AGCCTAAGTA TGGCAGTTCA TTGGCCTCAA 19489 GTTTTCAACA TGATTCCATC TTTGGAGGCC CTCCTTGTTT CCTGCAGCTC ACTTCCAGGC 19549 TCAGCCCAGC CGCTGAACAC AACTAAACTT CACAAAACTT GTAGTGCTTC ATGTTTCAAG 19609 GAATGATGAC TTTGTCAATT CAATGGTACC 19639 (2) INFORMATION FOR SEQ ID NO:7: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1025 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:7: Met Ile Ser Leu Pro Leu Leu Leu Phe Val Leu Leu Phe Ser Ala Leu 1 5 10 15 Leu Leu Cys Pro Ser Ser Ser Asp Asp Asp Gly Asp Ala Ala Gly Asp 20 25 30 Glu Leu Ala Leu Leu Ser Phe Lys Ser Ser Leu Leu Tyr Gln Gly Gly 35 40 45 Gln Ser Leu Ala Ser Trp Asn Thr Ser Gly His Gly Gln His Cys Thr 50 55 60 Trp Val Gly Val Val Cys Gly Arg Arg Arg Arg Arg His Pro His Arg 65 70 75 80 Val Val Lys Leu Leu Leu Arg Ser Ser Asn Leu Ser Gly Ile Ile Ser 85 90 95 Pro Ser Leu Gly Asn Leu Ser Phe Leu Arg Glu Leu Asp Leu Gly Asp 100 105 110 Asn Tyr Leu Ser Gly Glu Ile Pro Pro Glu Leu Ser Arg Leu Ser Arg 115 120 125 Leu Gln Leu Leu Glu Leu Ser Asp Asn Ser Ile Gln Gly Ser Ile Pro 130 135 140 Ala Ala Ile Gly Ala Cys Thr Lys Leu Thr Ser Leu Asp Leu Ser His 145 150 155 160 Asn Gln Leu Arg Gly Met Ile Pro Arg Glu Ile Gly Ala Ser Leu Lys 165 170 175 His Leu Ser Asn Leu Tyr Leu Tyr Lys Asn Gly Leu Ser Gly Glu Ile 180 185 190 Pro Ser Ala Leu Gly Asn Leu Thr Ser Leu Gln Glu Phe Asp Leu Ser 195 200 205 Phe Asn Arg Leu Ser Gly Ala Ile Pro Ser Ser Leu Gly Gln Leu Ser 210 215 220 Ser Leu Leu Thr Met Asn Leu Gly Gln Asn Asn Leu Ser Gly Met Ile 225 230 235 240 Pro Asn Ser Ile Trp Asn Leu Ser Ser Leu Arg Ala Phe Ser Val Arg 245 250 255 Glu Asn Lys Leu Gly Gly Met Ile Pro Thr Asn Ala Phe Lys Thr Leu 260 265 270 His Leu Leu Glu Val Ile Asp Met Gly Thr Asn Arg Phe His Gly Lys 275 280 285 Ile Pro Ala Ser Val Ala Asn Ala Ser His Leu Thr Val Ile Gln Ile 290 295 300 Tyr Gly Asn Leu Phe Ser Gly Ile Ile Thr Ser Gly Phe Gly Arg Leu 305 310 315 320 Arg Asn Leu Thr Glu Leu Tyr Leu Trp Arg Asn Leu Phe Gln Thr Arg 325 330 335 Glu Gln Asp Asp Trp Gly Phe Ile Ser Asp Leu Thr Asn Cys Ser Lys 340 345 350 Leu Gln Thr Leu Asn Leu Gly Glu Asn Asn Leu Gly Gly Val Leu Pro 355 360 365 Asn Ser Phe Ser Asn Leu Ser Thr Ser Leu Ser Phe Leu Ala Leu Glu 370 375 380 Leu Asn Lys Ile Thr Gly Ser Ile Pro Lys Asp Ile Gly Asn Leu Ile 385 390 395 400 Gly Leu Gln His Leu Tyr Leu Cys Asn Asn Asn Phe Arg Gly Ser Leu 405 410 415 Pro Ser Ser Leu Gly Arg Leu Lys Asn Leu Gly Ile Leu Leu Ala Tyr 420 425 430 Glu Asn Asn Leu Ser Gly Ser Ile Pro Leu Ala Ile Gly Asn Leu Thr 435 440 445 Glu Leu Asn Ile Leu Leu Leu Gly Thr Asn Lys Phe Ser Gly Trp Ile 450 455 460 Pro Tyr Thr Leu Ser Asn Leu Thr Asn Leu Leu Ser Leu Gly Leu Ser 465 470 475 480 Thr Asn Asn Leu Ser Gly Pro Ile Pro Ser Glu Leu Phe Asn Ile Gln 485 490 495 Thr Leu Ser Ile Met Ile Asn Val Ser Lys Asn Asn Leu Glu Gly Ser 500 505 510 Ile Pro Gln Glu Ile Gly His Leu Lys Asn Leu Val Glu Phe His Ala 515 520 525 Glu Ser Asn Arg Leu Ser Gly Lys Ile Pro Asn Thr Leu Gly Asp Cys 530 535 540 Gln Leu Leu Arg Tyr Leu Tyr Leu Gln Asn Asn Leu Leu Ser Gly Ser 545 550 555 560 Ile Pro Ser Ala Leu Gly Gln Leu Lys Gly Leu Glu Thr Leu Asp Leu 565 570 575 Ser Ser Asn Asn Leu Ser Gly Gln Ile Pro Thr Ser Leu Ala Asp Ile 580 585 590 Thr Met Leu His Ser Leu Asn Leu Ser Phe Asn Ser Phe Val Gly Glu 595 600 605 Val Pro Thr Ile Gly Ala Phe Ala Ala Ala Ser Gly Ile Ser Ile Gln 610 615 620 Gly Asn Ala Lys Leu Cys Gly Gly Ile Pro Asp Leu His Leu Pro Arg 625 630 635 640 Cys Cys Pro Leu Leu Glu Asn Arg Lys His Phe Pro Val Leu Pro Ile 645 650 655 Ser Val Ser Leu Ala Ala Ala Leu Ala Ile Leu Ser Ser Leu Tyr Leu 660 665 670 Leu Ile Thr Trp His Lys Arg Thr Lys Lys Gly Ala Pro Ser Arg Thr 675 680 685 Ser Met Lys Gly His Pro Leu Val Ser Tyr Ser Gln Leu Val Lys Ala 690 695 700 Thr Asp Gly Phe Ala Pro Thr Asn Leu Leu Gly Ser Gly Ser Phe Gly 705 710 715 720 Ser Val Tyr Lys Gly Lys Leu Asn Ile Gln Asp His Val Ala Val Lys 725 730 735 Val Leu Lys Leu Glu Asn Pro Lys Ala Leu Lys Ser Phe Thr Ala Glu 740 745 750 Cys Glu Ala Leu Arg Asn Met Arg His Arg Asn Leu Val Lys Ile Val 755 760 765 Thr Ile Cys Ser Ser Ile Asp Asn Arg Gly Asn Asp Phe Lys Ala Ile 770 775 780 Val Tyr Asp Phe Met Pro Asn Gly Ser Leu Glu Asp Trp Ile His Pro 785 790 795 800 Glu Thr Asn Asp Gln Ala Asp Gln Arg His Leu Asn Leu His Arg Arg 805 810 815 Val Thr Ile Leu Leu Asp Val Ala Cys Ala Leu Asp Tyr Leu His Arg 820 825 830 His Gly Pro Glu Pro Val Val His Cys Asp Ile Lys Ser Ser Asn Val 835 840 845 Leu Leu Asp Ser Asp Met Val Ala His Val Gly Asp Phe Gly Leu Ala 850 855 860 Arg Ile Leu Val Asp Gly Thr Ser Leu Ile Gln Gln Ser Thr Ser Ser 865 870 875 880 Met Gly Phe Ile Gly Thr Ile Gly Tyr Ala Ala Pro Glu Tyr Gly Val 885 890 895 Gly Leu Ile Ala Ser Thr His Gly Asp Ile Tyr Ser Tyr Gly Ile Leu 900 905 910 Val Leu Glu Ile Val Thr Gly Lys Arg Pro Thr Asp Ser Thr Phe Arg 915 920 925 Pro Asp Leu Gly Leu Arg Gln Tyr Val Glu Leu Gly Leu His Gly Arg 930 935 940 Val Thr Asp Val Val Asp Thr Lys Leu Ile Leu Asp Ser Glu Asn Trp 945 950 955 960 Leu Asn Ser Thr Asn Asn Ser Pro Cys Arg Arg Ile Thr Glu Cys Ile 965 970 975 Val Trp Leu Leu Arg Leu Gly Leu Ser Cys Ser Gln Glu Leu Pro Ser 980 985 990 Ser Arg Thr Pro Thr Gly Asp Ile Ile Asp Glu Leu Asn Ala Ile Lys 995 1000 1005 Gln Asn Leu Ser Gly Leu Phe Pro Val Cys Glu Gly Gly Ser Leu Glu 1010 1015 1020 Phe 1025 (2) INFORMATION FOR SEQ ID NO:8: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9424 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (vi) ORIGINAL SOURCE: (A) ORGANISM: Oryza longistaminata (B) STRAIN: IRBB21 (viii) POSITION IN GENOME: (A) CHROMOSOME/SEGMENT: 11 (B) MAP POSITION: 11q, RG103 (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 2819..5260 (D) OTHER INFORMATION: /product= “receptor kinase-like protein” /note= “Xa21 gene family member E” (ix) FEATURE: (A) NAME/KEY: misc_feature (B) LOCATION: 5211..8128 (D) OTHER INFORMATION: /note= “truncator, an insertion sequence with the characteristics of a transposon” (ix) FEATURE: (A) NAME/KEY: misc_feature (B) LOCATION: 5484..5665 (D) OTHER INFORMATION: /note= “Snap-Ol2, transposon-like element” (ix) FEATURE: (A) NAME/KEY: intron (B) LOCATION: 8357..8644 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:8: AAGCTTCACT TTTCCCCTAT TTTGTTAAGA TCAGTTAATG GTGTCAATTC AGCCATAAAA 60 AGACATGTAT CCCTTTTACA TTTGCCCACA AAAAAATTTG CTGGGTCACA TTAGATATAC 120 GGACACACAT TTGAAGTATT AAACGTAGAC TAATACAAAG CAAATTATAT AATCCGCATG 180 TAAACTGCGA GACGAATTTA TTAAGCCTAA TTAATCCGTC ATTAGCAAAT GTTTACTGTA 240 GCACTACATT GTTAGATCAT GGTGCAATTA GGCTTAAAAG ATTTGTCTCG TAATTTACAC 300 ACAAACTGTG TAATTAGTTT TTTCAATATT TAATACTTCG TACATGTATT TAAACGTTTG 360 ATGTGACGGG ACAAAAAAAA AATTGCCGGT GGGTCTAAAT CCACCACCCC CCCTCCTCTT 420 AGAGTTGATA TACATTTTCA CACAACTTGC ACGGCTGCAA AACTTGACTA AAAAGATTCA 480 TGACAAATTT CTCGCAAATA TTGAGATAGG AAAAGAGAGA GAGAAAATCA GGTAGCAACG 540 GCATCTCGCT GGTCTTTGTG AACGGGAAAC TATTTTAACA GCTCGAGTGG ACGTCAACCC 600 GTTTATTGCA TGTCATCTAA ATGGTTATAA AAAAAATTGA AAAAATATGA ATAAGGATAG 660 ATCAATATGT AATATATCAA TCCACAAACA TGCAAGTTAA AATTTAACTT CTACAAGTTG 720 TAATAAAAAT AAGAAACAAA ACTCAAATTA CTATATGTAT ATTTACAATT AAATTTGTTA 780 TTTTTGTTAT AACCTGTAGA AGTTAAATTT GAACTTGCAT GTTTGTGGAG TGATATATTA 840 CATATTGATC TATCTTGTCA ATTTTTTTGA AAATTTTTCG TAACCATCTA GTTGACATGC 900 AATAAACGGA TGGACGTCCA CTCGAGTGCT GCTAGGGCGG ATCTATAGTA CGTTGTCAGG 960 CGACACCGAT GACTCCCGGT AAAAACCTAT AGCAAAACTG CTTATTCATA TGTTATAACA 1020 CCATGATCTA AACATAATTA GTATACTATG ATACCGTTAG ACACGTTATG ACACCAATGA 1080 ATCGATTTTC TGGATCCGCC ACAGTGCACG GGATTGGGAT GGGAACGGCC GATGGACGCT 1140 GTGTGTTGGG CTAGCTAGGT GGGGTTGGGA GTTGGGACTA GGTAGGTTAT TTTTGCCAGG 1200 GGTACAATAG TTCTTTTGCA TTTTGTAACT CTTCTTTTTC TTTCGAGATA ATCCATTATA 1260 TGCCATTAAC TTTGTCGCAC GTCTACGATT TGCCACTGAC TTTGTCACGT TCTACAATAT 1320 GCCATCGACT TTTTCTTAAC TTCTACGATT TACCATCGCC GTCCGGTTAG CCACTTTTAG 1380 TACTGTACAA ATTTGTTGAA ATGACCAAAA TACCCCTATG ACAAAAATAT CCAAAATTTG 1440 GATAAAATTA TCAAAATATT ATATTATAAA CATAAGATTG TAAACATCCA AAATTTGACC 1500 AAAAACTTGA AATATGATAT TTCATAATTT TTATCCAAAT TTTGAAACCT TTTCTCCCAG 1560 GGGTATTTTG GTCATTTTGA CAAATTTGTA CAGTACTAAC GGAGACTAAC CGGACGGCGA 1620 TGGTAAATTG TAGAAGTTAA GCAAAAGTCG ATGGCATATC GTAGAACATG ATAAAGTCAG 1680 TGGCAAATCA TAGACGTGTG ACAAAGTCAG TGGTATATAA TGGTTTCTCT CTTTTCTTTT 1740 TCTCTCAGAA ATTTGGGCCC AGCTAATTTT TGCCAATGTT GTTGCAAGAA CTCAACAAGT 1800 GTATCAACCT CTCTTCTGTA TTCCATCTGC CTTCTATGGG TGATTATTTA CACATTTATA 1860 TACAGGGATA TACAAGAGGA AAATGCTTCG GTGCCCCTAT CCTTACGATG TGCCTATGTG 1920 ACTGGCCGGT GGGCCAGCCT TGGTCCTAAT GGTAACTTGA TGGAGGACAG GAGAGCTGCC 1980 CCCGGCATGG GGGCATCGCT GTTCCCGAGG GACCTTGCTA CTACCCGGGT AAAGGCATCC 2040 CCGGGTAATA GCATGCTCCG CCTAGCTGCC ATCAATAGTG TCAGTGTTAG TTGGGGCGCG 2100 TAGTGCGCAT TTATTCGCGC CCCTAGCGCC TGGTTCTTGA CTTGCTTGCG CGAGCACATC 2160 GAGGCATAAT TCACTCCGGT TGGCACATCG GGCTTTAGGG GCCCCTCGGA GCTCCGAAGC 2220 CCTTAGGTAG CCTCCGGAGC TCCCCTTCCG GACTCCGGGT ACCTTTCAGG CTTCGGAGCT 2280 CGGTCACTAG GTGTGTCACC GGAGCCCATG GCGCTCGACC TCCCGGAGCT CTTCCGGAGC 2340 CGGTCGGCCG CCATCCGAAG CCTGCTTAGG TCTTGTTCCT CTCGCCCTCA ATGAGATCCG 2400 ATTCTCTCGG ATCTCCGGAG GCCTCCGGAG CAGGGGGGCC AGCCGCGGAC CGACATGGCC 2460 TTGATTCACG GTCATCTCCC GGGGAGGATG GTTCTCCGGA GTGCTGCAGC CCTTCGGAGG 2520 CTAGCGTCCC TTGATCCGGA GATACTCCCC TAACACCTTC TTATTCAACC AAGCTAGGAC 2580 CAATGACCAT GACCCTTTTG GATATCAAGA TGACCACAGG TTTAGATATC CTCTTAATCA 2640 GCCAACCGTT TTCCAGTCAG AAAATCAAGT GTGCCAACAA GTTGCGGACC AAGAATGTTG 2700 GTGGTTGGTC AGGCTACATC ACTTTTTCTT ATATCTGTCT AAGTCCATGA GCTAAACCAA 2760 AAACATCTCT CGCTCTTGCT GTCTTAGCTT GCACCGATAT TCTCTGCATC TCGGCACG 2818 ATG ATA TCA CTC CCA TTA CTG CTC TTC GTC CTC TTC TTC TCT GCG CTG 2866 Met Ile Ser Leu Pro Leu Leu Leu Phe Val Leu Phe Phe Ser Ala Leu 1 5 10 15 CTG CTC TTC CCT TCG AGC AGT GAC GAC GAC GGT GGT GGT GAT GCT GCC 2914 Leu Leu Phe Pro Ser Ser Ser Asp Asp Asp Gly Gly Gly Asp Ala Ala 20 25 30 GGC GAC GAA CTC GCG CTG CTC TCT TTC AAG TCA TCC CTG CTA TAC CAG 2962 Gly Asp Glu Leu Ala Leu Leu Ser Phe Lys Ser Ser Leu Leu Tyr Gln 35 40 45 GGG GGC CAG TCG CTG GCA TCT TGG AAC ACG TCC GGC CAT GGC CAG CAC 3010 Gly Gly Gln Ser Leu Ala Ser Trp Asn Thr Ser Gly His Gly Gln His 50 55 60 TGC ACA TGG GTG GGT GTC GTG TGC GGC CGC CGG CAC CCA CAC AGG GTG 3058 Cys Thr Trp Val Gly Val Val Cys Gly Arg Arg His Pro His Arg Val 65 70 75 80 GTG AAG CTG CGG CTG CGC TCC TCC AAC CTG GCC GGG ATC ATC TCG CCG 3106 Val Lys Leu Arg Leu Arg Ser Ser Asn Leu Ala Gly Ile Ile Ser Pro 85 90 95 TCG CTG GGC AAC CTA TCC TTC CTC AGG ACG CTG CAA CTC AGC GAC AAC 3154 Ser Leu Gly Asn Leu Ser Phe Leu Arg Thr Leu Gln Leu Ser Asp Asn 100 105 110 CAC CTG TCC GGC AAG ATA CCC CAG GAG CTC AGC CGT CTC AGC AGG CTC 3202 His Leu Ser Gly Lys Ile Pro Gln Glu Leu Ser Arg Leu Ser Arg Leu 115 120 125 CAG CAA CTG GTA CTG AAT TTC AAC AGC CTA TCG GGT GAG ATT CCA GCT 3250 Gln Gln Leu Val Leu Asn Phe Asn Ser Leu Ser Gly Glu Ile Pro Ala 130 135 140 GCT TTG GGC AAT CTA ACC AGT CTC TCG GTT CTT GAG CTG ACT AAC AAT 3298 Ala Leu Gly Asn Leu Thr Ser Leu Ser Val Leu Glu Leu Thr Asn Asn 145 150 155 160 ACA CTG TCC GGA GCA ATC CCT TCA TCT CTG GGC AAA CTC ACA GGT CTC 3346 Thr Leu Ser Gly Ala Ile Pro Ser Ser Leu Gly Lys Leu Thr Gly Leu 165 170 175 ACT GAT CTT GCA CTG GCT GAA AAT ACG CTG TCT GGT TCC ATC CCA TCA 3394 Thr Asp Leu Ala Leu Ala Glu Asn Thr Leu Ser Gly Ser Ile Pro Ser 180 185 190 TCT TTC GGC CAA TTG CGC AGA TTA TCT TTC CTT AGC TTA GCC TTT AAC 3442 Ser Phe Gly Gln Leu Arg Arg Leu Ser Phe Leu Ser Leu Ala Phe Asn 195 200 205 AAT TTA AGT GGA GCG ATC CCA GAT CCT ATT TGG AAC ATC TCC TCT CTC 3490 Asn Leu Ser Gly Ala Ile Pro Asp Pro Ile Trp Asn Ile Ser Ser Leu 210 215 220 ACC ATA TTC GAA GTC ATA TCC AAC AAG CTA AGT GGT ACA CTG CCT ACA 3538 Thr Ile Phe Glu Val Ile Ser Asn Lys Leu Ser Gly Thr Leu Pro Thr 225 230 235 240 AAT GCA TTC AGT AAT CTT CCT AGT CTG CAG GAG GTA TAC ATG TAT TAC 3586 Asn Ala Phe Ser Asn Leu Pro Ser Leu Gln Glu Val Tyr Met Tyr Tyr 245 250 255 AAC CAG TTT CAT GGT CGT ATC CCG GCA TCG ATA GGT AAT GCT TCC AAC 3634 Asn Gln Phe His Gly Arg Ile Pro Ala Ser Ile Gly Asn Ala Ser Asn 260 265 270 ATC TCA ATA TTT ACC ATT GGT TTA AAC TCT TTT AGC GGT GTT GTT CCA 3682 Ile Ser Ile Phe Thr Ile Gly Leu Asn Ser Phe Ser Gly Val Val Pro 275 280 285 CCG GAG ATT GGA AGG ATG AGA AAT CTT CAG AGA CTA GAG CTT CCA GAA 3730 Pro Glu Ile Gly Arg Met Arg Asn Leu Gln Arg Leu Glu Leu Pro Glu 290 295 300 ACT CTT TCG GAA GCT GAA GAA ACA AAT GAT TGG AAA TTC ATG ACG GCA 3778 Thr Leu Ser Glu Ala Glu Glu Thr Asn Asp Trp Lys Phe Met Thr Ala 305 310 315 320 TTG ACA AAT TGC TCC AAT CTT CAA GAA GTG GAA CTG GGA GGT TGT AAA 3826 Leu Thr Asn Cys Ser Asn Leu Gln Glu Val Glu Leu Gly Gly Cys Lys 325 330 335 TTT GGT GGA GTC CTC CCT GAT TCT GTT TCC AAT CTT TCC TCT TCG CTT 3874 Phe Gly Gly Val Leu Pro Asp Ser Val Ser Asn Leu Ser Ser Ser Leu 340 345 350 GTA TCT CTC TCC ATT AGA GAT AAC AAA ATT TCA GGG AGC TTA CCT AGA 3922 Val Ser Leu Ser Ile Arg Asp Asn Lys Ile Ser Gly Ser Leu Pro Arg 355 360 365 GAT ATC GGT AAT CTC GTT AAT TTA CAA TAT CTT TCT CTC GCT AAC AAC 3970 Asp Ile Gly Asn Leu Val Asn Leu Gln Tyr Leu Ser Leu Ala Asn Asn 370 375 380 TCC TTG ACA GGA TCC CTT CCC TCT TCC TTC AGC AAG CTT AAA AAT TTA 4018 Ser Leu Thr Gly Ser Leu Pro Ser Ser Phe Ser Lys Leu Lys Asn Leu 385 390 395 400 CGT CGT CTC ACT GTA GAT AAC AAC AAG TTA ATT GGT TCT CTC CCA TTG 4066 Arg Arg Leu Thr Val Asp Asn Asn Lys Leu Ile Gly Ser Leu Pro Leu 405 410 415 ACC ATC GGT AAT CTT ACA CAA CTA ACT AAT ATG GAG GTC CAA TTT AAT 4114 Thr Ile Gly Asn Leu Thr Gln Leu Thr Asn Met Glu Val Gln Phe Asn 420 425 430 GCC TTC GGT GGT ACA ATA CCA AGC ACA CTT GGA AAC CTG ACC AAG CTG 4162 Ala Phe Gly Gly Thr Ile Pro Ser Thr Leu Gly Asn Leu Thr Lys Leu 435 440 445 TTT CAA ATA AAT CTT GGC CAC AAT AAC TTT ATA GGG CAA ATT CCC ATT 4210 Phe Gln Ile Asn Leu Gly His Asn Asn Phe Ile Gly Gln Ile Pro Ile 450 455 460 GAA ATA TTT AGC ATT CCC GCA CTC TCT GAA ATT TTG GAT GTG TCC CAT 4258 Glu Ile Phe Ser Ile Pro Ala Leu Ser Glu Ile Leu Asp Val Ser His 465 470 475 480 AAT AAC TTG GAG GGA TCA ATA CCA AAA GAA ATA GGG AAA CTT AAA AAT 4306 Asn Asn Leu Glu Gly Ser Ile Pro Lys Glu Ile Gly Lys Leu Lys Asn 485 490 495 ATT GTC GAA TTC CAT GCT GAT TCG AAC AAA TTA TCG GGT GAG AAC CCT 4354 Ile Val Glu Phe His Ala Asp Ser Asn Lys Leu Ser Gly Glu Asn Pro 500 505 510 AGC ACC ATT GGT GAA TGC CAA CTT CTG CAG CAT CTT TTC CTG CAA AAC 4402 Ser Thr Ile Gly Glu Cys Gln Leu Leu Gln His Leu Phe Leu Gln Asn 515 520 525 AAT TTC TTA AAT GGT AGC ATC CCA ATA GCT CTG ACT CAG TTG AAA GGT 4450 Asn Phe Leu Asn Gly Ser Ile Pro Ile Ala Leu Thr Gln Leu Lys Gly 530 535 540 CTG GAC ACA CTT GAT CTC TCA GGT AAC AAT TTG TCA GGT CAG ATA CCT 4498 Leu Asp Thr Leu Asp Leu Ser Gly Asn Asn Leu Ser Gly Gln Ile Pro 545 550 555 560 ATG TCC TTA GGG GAC ATG CCT CTT CTC CAC TCG CTG AAC CTT TCG TTC 4546 Met Ser Leu Gly Asp Met Pro Leu Leu His Ser Leu Asn Leu Ser Phe 565 570 575 AAC AGC TTC CAC GGT GAA GTG CCA ACC AAT GGT GTT TTT GCA AAT GCT 4594 Asn Ser Phe His Gly Glu Val Pro Thr Asn Gly Val Phe Ala Asn Ala 580 585 590 TCT GAA ATT TAC ATC CAA GGC AAT GCC CAT ATT TGC GGT GGC ATA CCT 4642 Ser Glu Ile Tyr Ile Gln Gly Asn Ala His Ile Cys Gly Gly Ile Pro 595 600 605 GAA CTA CAT CTT CCG ACG TGT TCC TTA AAA TCA AGA AAG AAA AAG AAA 4690 Glu Leu His Leu Pro Thr Cys Ser Leu Lys Ser Arg Lys Lys Lys Lys 610 615 620 CAT CAA ATT CTG CTG TTA GTG GTT GTT ATC TGT CTC GTT TCG ACA CTT 4738 His Gln Ile Leu Leu Leu Val Val Val Ile Cys Leu Val Ser Thr Leu 625 630 635 640 GCC GTC TTT TCG TTA CTC TAC ATG CTT CTA ACC TGT CAT AAG AGA AGA 4786 Ala Val Phe Ser Leu Leu Tyr Met Leu Leu Thr Cys His Lys Arg Arg 645 650 655 AAG AAA GAA GTC CCT GCA ACG ACA TCC ATG CAA GGC CAC CCA ATG ATC 4834 Lys Lys Glu Val Pro Ala Thr Thr Ser Met Gln Gly His Pro Met Ile 660 665 670 ACT TAC AAG CAG CTG GTA AAA GCA ACG GAT GGT TTT TCG TCC AGC CAT 4882 Thr Tyr Lys Gln Leu Val Lys Ala Thr Asp Gly Phe Ser Ser Ser His 675 680 685 TTG TTG GGT TCT GGA TCT TTT GGC TCT GTT TAC AAA GGA GAA TTT GAT 4930 Leu Leu Gly Ser Gly Ser Phe Gly Ser Val Tyr Lys Gly Glu Phe Asp 690 695 700 AGT CAA GAT GGT GAA ATC ACA AGT CTT GTT GCC GTG AGG GTA CTA AAG 4978 Ser Gln Asp Gly Glu Ile Thr Ser Leu Val Ala Val Arg Val Leu Lys 705 710 715 720 CTG GAA ACT CCA AAG GCA CTC AAG AGT TTC ACG GCC GAA TGC GAA ACA 5026 Leu Glu Thr Pro Lys Ala Leu Lys Ser Phe Thr Ala Glu Cys Glu Thr 725 730 735 CTG CGA AAT ACT CGA CAC CGG AAT CTT GTC AAG ATA GTT ACG ATT TGC 5074 Leu Arg Asn Thr Arg His Arg Asn Leu Val Lys Ile Val Thr Ile Cys 740 745 750 TCG AGC ATC GAT AAC AGA GGG AAT GAT TTC AAA GCA ATT GTG TAT GAC 5122 Ser Ser Ile Asp Asn Arg Gly Asn Asp Phe Lys Ala Ile Val Tyr Asp 755 760 765 TTC ATG CCC AAT GGC AGT CTG GAA GAT TGG CTA CAC CCT GAA ACA AAT 5170 Phe Met Pro Asn Gly Ser Leu Glu Asp Trp Leu His Pro Glu Thr Asn 770 775 780 GAT CAA GCA GAG CAA AGG CAC TTG ACT CTG CAT CAG AGA GTG TCA CGC 5218 Asp Gln Ala Glu Gln Arg His Leu Thr Leu His Gln Arg Val Ser Arg 785 790 795 800 CGG AAT TTC TAT CCA AAA TTC CAA ACG CTT ACA TGT GTG TGAACCCTCG 5267 Arg Asn Phe Tyr Pro Lys Phe Gln Thr Leu Thr Cys Val 805 810 TCCAGGAATC AGCCGAGACA CACAATAACA AATTGATAAT AGAGTACAAT TATTACTCTA 5327 ATTAATAAGC GTATAAAATG TCATTACAGA GGTAGATAGT TCCTCTCAAT CAATAAAGAT 5387 CTAAGCAGCG GAAAAATAAG ATAAACGGCG CAGACGGCTC CACTCCACAG GCAGCTTGAC 5447 CAAGGCTACA CCTAATCCTC CACACCATCA GCTTCACTGT AGAACTCTTC CTCTGATGAA 5507 TGATTGCAAG GTGAGTATAT GACATACTCA GCAAGCCACG CAGCAAATAT GCAAGTGCAC 5567 AGGATAACAA AGGATGGCAT AGTAGGGTTT TATTTGCAAA AGCAGCATTT AGCAAACATT 5627 TGAGAATTTA ATAAAACAGT TAAGTAATTA AACAATATTA ATCCAACGCT ATACAACATA 5687 CCCTGTTGTA TAGGCCCAAC CATTCTGAAC AACCATCCCG GCTGCACAGT TCTATCTCCA 5747 AACCAGGAAT ATACCATTCC AAACCAGGAG CTAATCAAAT TATTACCAAT TAAAGCACCT 5807 TTTATTATGA TGAGAAGGGT GAGACTAATC ACGAAAGATA TTGTTAGACC CGCCTATAAC 5867 CGCGGGCACG GCTATTCGAA TAGTTTTACT CTGATCAGAG GTGTACCACT GTACCCACAA 5927 GACACAACCC CACATCATGT CACCATGTGC CTCAATACCA CCACGGTACC TCGGAAAGGA 5987 GTTGTGACAA TACCCCTTGC ATAACACAAT CCACTGCAGT GCACCTTCCT GGATCATAAT 6047 CACCCCCTTA AAAACAAGGC ATGGACTCCC CAGCGACCCT CGTGGGCTTA TCTCCGCCAC 6107 TTCTCAGTCT GGTGCCCCGC AATGAACCAT GCTATATAAA AGATAAAGCC GTTGCCCATG 6167 CTGGCTTATG GTTGGCACGG TTAATGTTTC ACAACCGAAA CTCGTGAACC GGTCCTTAAT 6227 TGTCATGAGC ACGACCATCA AAACCATGTG CTCACAACCC ACCATTATCA GGTTTTAGTT 6287 GGCAAATAAT TAATTAACAA ATCACGATTG ACCATCGTGA ACTATCATTA AGCCATCATT 6347 AAATAACAGT GAGTCATAAG TTATCCCAAT AGTAAGCTAA TGTTTCTAAG CAGGGCTAAG 6407 CAATTATATC TAATATCTAG TTGAACCAAT ATATAAAGCT CACTAGTCAA ATTATAATAA 6467 CCCAAGGTAT CAAGGAATAA AGTAATCAAT AACAAAAGGG CTATAACAAA CAATAGGTTA 6527 ATTCCACCCA ATGACATTCG AAAATAAATG CAATATTTGA ATAGAAACAA TAGCTTTAAA 6587 TAGGATCAAC ATGCTCAAAG GGTTGTATGG GATCTGTGTG ACTTGCCTTG CTGGCCTTGG 6647 AACTCTTCAA ACTCTTCTCC GGCGAAAACG GACTCTCCGG AAACGACGGA ATCTAAACAA 6707 AAAGAAGCAA AACCACCAAA ACAGCACATA AACCAACTAA ATCGGAGCTA AGATGAATTA 6767 GTTATGAATT TTTGAAGATT AAATCGGATT AAAACACTTA AATTGATTTT AATTGAATTA 6827 TGACGCAATA ATGAATTATT TTTGAAAAGG AAAAGGAGGA TTATTGCGTC AGCGGGCTAG 6887 GGTTTCGGTG GACCGGGCAC ACAGGCGACG GCTCACGCGA ACGGACGGCC GAGATCGACT 6947 TGATCCAAAA CGGACGGCCG AGATCGAACG GTCCACGACC GGCTCACAGC GAACGGCCCC 7007 GATGACGTCG GCGATGACGT CACCACCGGC GGCGGCGGCT CGGCGGCTCG GGCTTGCACG 7067 CTCGCCGGCG AACGACGGCA CGGCGGCGCG AATGGAAGGC ACCAACGGGT AGAGCGCGAC 7127 GCGGCGAACT CACCGGTGAC CAAAAGAGCG GCGGAAGATC AATGGACGGC GACGGCGACG 7187 AGGAGGAAGC GGCGGCAAAC TTCGGGTCGA CGGTGGCGAC GGTGCTCCGG CGGTCTTCGG 7247 CGGCGGCAAA GGAGCGGACG AGAACGGCGG CGACTTGGCG ATCACGACGG TGGCCTTCCC 7307 GAGCGATGAT GACGACCGAG ACGGCGGCGA CGCACGGCTG GAGCGACGGC TACGACGGCG 7367 GCGCTAGGTT GCACGGCGCT AGAGCTCTTC CGGCGACGAG AGGCGAAGGC GAAGGTGGCG 7427 ACGGGTAGAG GAGACACCGG GGAACCTTTT AAAGGGGCTC GCAGGCGACG GCGAAGGCCC 7487 ACGGCGGCTG GCGACGAGAA GGAAGGTTTA GGGTTCGGAG GAGGGAGACG AATCCGATTC 7547 GAACTCGATT CCAACGATTT CCAAAACGAA TTAGCCGATG TTTCCAAAAG AGAAAAGGTA 7607 GAGGAGATCC CGGAGATTGT TTCCCCTCTA TCAATTCGGC CGGAAACGGA AAGGATCGAT 7667 CGAATTTGGA AGGGAACGGC GGCGGCGCGA AACTAGGGTT TCGGGCGGCG GCGGCCGGAG 7727 GTTGACGACG ACCCTGACAG GTTGGCCCCA CCTGTCAGCG GGCGGACGCG CGCGCGCGGC 7787 GGCGGACTGG GCCGGACTGG GCCGAGGAGA GAGAGAGCGG TTTTGGGCCG ACTTTCGGCC 7847 CAAAGCCAAA AGAGACTTTT TAAAACCTTT TTCAATTTAA ATTATTCATG AAATGTAATT 7907 CCATTTATTA AAAATACTTC CTTAGCTCAA ATAAATCCCA GAAAAATCTA GGAATTATAG 7967 AATTAAGCAA AGTATTTAAT GAAATTTTAT CTGGCCCCAT TTTATATTGT AATTTATTAA 8027 TTTAAAATTA GATCTTCTCT TCTAGGCTTT TAAAATAAAT TCTAAAAATT CCATTTAAAC 8087 AACAATTTAT ATATTTTGAA TTTTCAGGGT GTGACAGAGA GTGCCCATAC TACGTGATGT 8147 TGCATGTGCA TTGGACCATC TTCACTTCCA TGGCCCTGAC CCTATTGTAC ACTGTGATAT 8207 TAAATCAAGC AATGTGTTGT TAGATGCTGA TATGGTAGCC CATGTTGGAG ACTTTGGACT 8267 TGCAAGAATA CTTATTGAGG GAAGCTCATT GATGCAACAG TCAACAAGTT CGATGGGAAT 8327 CAGGGGGACA ATTGGTTACG CAGCACCAGG TTAATCCTAA ACTGTTTATG TCTACCTCCT 8387 TTCATTGTTT TTTTTAGATT TGCTCTGGTC CAACAAAAAA TACCTAAAGA TACAGATACT 8447 TGTACCTCAC AGTACTAAAT AGTTTTCGAT CATTGCATTG TTAGATCCAA CGATCAGGAA 8507 ACGATTTGGT ACCGTGACCG TGAGGTATCG GAATCTCGAG ATATTTTTTG TTCGACCGTA 8567 GCAAATCTAT TTTTTTGTTT GTTTTCTTCT CTTTAATGTT TTATGACTAT GAAATAATTT 8627 TTATTTCTGG AAAACAGAGT ATGGTGTCGG GAACACTGCC TCGACACATG GAGATATTTA 8687 CAGTTATGGA ATTCTAGTGT TGGAAACAGT AACCGGGCTG CGGCCGGCAG ATAGTACATT 8747 CAGACCTGGC TTGAGCCTCC GTCAGTACGT TGAACCGGGT CTACATGGTA GACTGATGGA 8807 TGTTGTTGAC AGGCAGCTTG GTTTGGCTTC CGAGACATGG CTTCAGGCTC GAGATGTTTC 8867 GCCATGCAGC AGTATTACTG ACTGCCTTGT TTCACTGCTT AGACTTGGGC TGTCTTGCTC 8927 TCAGGAATTG CCATCGAGTA GAACGCAAGC CGGAGATGTC ATCAATGAAC TGCGTGCCAT 8987 CACAGCGTCT CTCTCGATGT CATCCGACAT GTGAAGATGT GAGACATGCT GATGTTATGT 9047 CCGAGTATTT CGTTGTAATG TAATGTGAAG GGTGAGTGTG TGACTGCTTG GTTGTAAGCT 9107 ATTTCCTGAT CTGCCCATCA GATCATGTAT CTGTTCTATT GTTGTATTTC TCAGAACAAC 9167 TACACACCCT AAGTAGGAGT ACACAATAGT GTATTTGTGT GATTTCAATA TTGATGCATA 9227 CCCATGCTAT GTGCTAAAAT TATATACTGA AATTTTGAGA TGTCTGAAGT TAACAGTCAA 9287 TCGGGGAGCG ATTCACACCA TACCGCGAAA TCGACCTAAT CAGCTAATCT AATTCTACAG 9347 GCTGCCTTTG CATGACAGTG TGATATTAAA TTAGCCCAGC CCTTTTTAGC AAACGATGGG 9407 AGGGTCAATG CTCTAGA 9424 (2) INFORMATION FOR SEQ ID NO:9: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 813 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:9: Met Ile Ser Leu Pro Leu Leu Leu Phe Val Leu Phe Phe Ser Ala Leu 1 5 10 15 Leu Leu Phe Pro Ser Ser Ser Asp Asp Asp Gly Gly Gly Asp Ala Ala 20 25 30 Gly Asp Glu Leu Ala Leu Leu Ser Phe Lys Ser Ser Leu Leu Tyr Gln 35 40 45 Gly Gly Gln Ser Leu Ala Ser Trp Asn Thr Ser Gly His Gly Gln His 50 55 60 Cys Thr Trp Val Gly Val Val Cys Gly Arg Arg His Pro His Arg Val 65 70 75 80 Val Lys Leu Arg Leu Arg Ser Ser Asn Leu Ala Gly Ile Ile Ser Pro 85 90 95 Ser Leu Gly Asn Leu Ser Phe Leu Arg Thr Leu Gln Leu Ser Asp Asn 100 105 110 His Leu Ser Gly Lys Ile Pro Gln Glu Leu Ser Arg Leu Ser Arg Leu 115 120 125 Gln Gln Leu Val Leu Asn Phe Asn Ser Leu Ser Gly Glu Ile Pro Ala 130 135 140 Ala Leu Gly Asn Leu Thr Ser Leu Ser Val Leu Glu Leu Thr Asn Asn 145 150 155 160 Thr Leu Ser Gly Ala Ile Pro Ser Ser Leu Gly Lys Leu Thr Gly Leu 165 170 175 Thr Asp Leu Ala Leu Ala Glu Asn Thr Leu Ser Gly Ser Ile Pro Ser 180 185 190 Ser Phe Gly Gln Leu Arg Arg Leu Ser Phe Leu Ser Leu Ala Phe Asn 195 200 205 Asn Leu Ser Gly Ala Ile Pro Asp Pro Ile Trp Asn Ile Ser Ser Leu 210 215 220 Thr Ile Phe Glu Val Ile Ser Asn Lys Leu Ser Gly Thr Leu Pro Thr 225 230 235 240 Asn Ala Phe Ser Asn Leu Pro Ser Leu Gln Glu Val Tyr Met Tyr Tyr 245 250 255 Asn Gln Phe His Gly Arg Ile Pro Ala Ser Ile Gly Asn Ala Ser Asn 260 265 270 Ile Ser Ile Phe Thr Ile Gly Leu Asn Ser Phe Ser Gly Val Val Pro 275 280 285 Pro Glu Ile Gly Arg Met Arg Asn Leu Gln Arg Leu Glu Leu Pro Glu 290 295 300 Thr Leu Ser Glu Ala Glu Glu Thr Asn Asp Trp Lys Phe Met Thr Ala 305 310 315 320 Leu Thr Asn Cys Ser Asn Leu Gln Glu Val Glu Leu Gly Gly Cys Lys 325 330 335 Phe Gly Gly Val Leu Pro Asp Ser Val Ser Asn Leu Ser Ser Ser Leu 340 345 350 Val Ser Leu Ser Ile Arg Asp Asn Lys Ile Ser Gly Ser Leu Pro Arg 355 360 365 Asp Ile Gly Asn Leu Val Asn Leu Gln Tyr Leu Ser Leu Ala Asn Asn 370 375 380 Ser Leu Thr Gly Ser Leu Pro Ser Ser Phe Ser Lys Leu Lys Asn Leu 385 390 395 400 Arg Arg Leu Thr Val Asp Asn Asn Lys Leu Ile Gly Ser Leu Pro Leu 405 410 415 Thr Ile Gly Asn Leu Thr Gln Leu Thr Asn Met Glu Val Gln Phe Asn 420 425 430 Ala Phe Gly Gly Thr Ile Pro Ser Thr Leu Gly Asn Leu Thr Lys Leu 435 440 445 Phe Gln Ile Asn Leu Gly His Asn Asn Phe Ile Gly Gln Ile Pro Ile 450 455 460 Glu Ile Phe Ser Ile Pro Ala Leu Ser Glu Ile Leu Asp Val Ser His 465 470 475 480 Asn Asn Leu Glu Gly Ser Ile Pro Lys Glu Ile Gly Lys Leu Lys Asn 485 490 495 Ile Val Glu Phe His Ala Asp Ser Asn Lys Leu Ser Gly Glu Asn Pro 500 505 510 Ser Thr Ile Gly Glu Cys Gln Leu Leu Gln His Leu Phe Leu Gln Asn 515 520 525 Asn Phe Leu Asn Gly Ser Ile Pro Ile Ala Leu Thr Gln Leu Lys Gly 530 535 540 Leu Asp Thr Leu Asp Leu Ser Gly Asn Asn Leu Ser Gly Gln Ile Pro 545 550 555 560 Met Ser Leu Gly Asp Met Pro Leu Leu His Ser Leu Asn Leu Ser Phe 565 570 575 Asn Ser Phe His Gly Glu Val Pro Thr Asn Gly Val Phe Ala Asn Ala 580 585 590 Ser Glu Ile Tyr Ile Gln Gly Asn Ala His Ile Cys Gly Gly Ile Pro 595 600 605 Glu Leu His Leu Pro Thr Cys Ser Leu Lys Ser Arg Lys Lys Lys Lys 610 615 620 His Gln Ile Leu Leu Leu Val Val Val Ile Cys Leu Val Ser Thr Leu 625 630 635 640 Ala Val Phe Ser Leu Leu Tyr Met Leu Leu Thr Cys His Lys Arg Arg 645 650 655 Lys Lys Glu Val Pro Ala Thr Thr Ser Met Gln Gly His Pro Met Ile 660 665 670 Thr Tyr Lys Gln Leu Val Lys Ala Thr Asp Gly Phe Ser Ser Ser His 675 680 685 Leu Leu Gly Ser Gly Ser Phe Gly Ser Val Tyr Lys Gly Glu Phe Asp 690 695 700 Ser Gln Asp Gly Glu Ile Thr Ser Leu Val Ala Val Arg Val Leu Lys 705 710 715 720 Leu Glu Thr Pro Lys Ala Leu Lys Ser Phe Thr Ala Glu Cys Glu Thr 725 730 735 Leu Arg Asn Thr Arg His Arg Asn Leu Val Lys Ile Val Thr Ile Cys 740 745 750 Ser Ser Ile Asp Asn Arg Gly Asn Asp Phe Lys Ala Ile Val Tyr Asp 755 760 765 Phe Met Pro Asn Gly Ser Leu Glu Asp Trp Leu His Pro Glu Thr Asn 770 775 780 Asp Gln Ala Glu Gln Arg His Leu Thr Leu His Gln Arg Val Ser Arg 785 790 795 800 Arg Asn Phe Tyr Pro Lys Phe Gln Thr Leu Thr Cys Val 805 810 (2) INFORMATION FOR SEQ ID NO:10: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5940 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (vi) ORIGINAL SOURCE: (A) ORGANISM: Oryza longistaminata (B) STRAIN: IRBB21 (viii) POSITION IN GENOME: (A) CHROMOSOME/SEGMENT: 11 (B) MAP POSITION: 11q, RG103 (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 2151..5855 (D) OTHER INFORMATION: /product= “receptor kinase-like protein” /note= “Xa21 family member A2; truncated by two mutations” (ix) FEATURE: (A) NAME/KEY: mutation (B) LOCATION: replace(2501..2503, “acc”) (D) OTHER INFORMATION: /note= “mutation compared to family member A1” (ix) FEATURE: (A) NAME/KEY: mutation (B) LOCATION: replace(4355..4356, “ac”) (D) OTHER INFORMATION: /note= “mutation compared to family member A1” (ix) FEATURE: (A) NAME/KEY: misc_feature (B) LOCATION: 5453..5697 (D) OTHER INFORMATION: /note= “Tourist-Ol2, transposon-like element” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:10: TCTAGAAATT GAATTTTAAA ATTGAATATA ATAGAGAAAT ACAACTGAAC ATAAATATTT 60 TGTCATTTTC ATTCCATTTA CATGTTTTTA AATCTAAATT TACAGTGCAT TTTGTATGTA 120 ATTCTAATAC AAATTTACTG TAATTTGTAT TTTTAGTCAT TTTTTCAGTT TCTAAAAGTA 180 CAGTGCACTT CAGTGACCTC CTTAGTAAGC TATGGGGGGA AAATGGATAT GCACATCTGA 240 TCTATCTATG AAACATAGAA GAAATATTCA TCACCATGTA CTACTTTTTA TGAATGTTTG 300 TTGGCCAGAT AGGATCTGAA AGATTTCTAG TACAGGGTTG TTTCATGTAT TGTTTCAGAT 360 AGGATCTGAA ATAACCACTG TACAGGGTTG TTTCTTGTAT GGTTTCCGCA TATTTAAACT 420 TTTGGTTGCA GATGTATGGC TAATCAATTA TGCAGTTTTA TGGCAAACAA AAAGGGTGGC 480 AATAGAGTAT ATTTCATCAT GTGGTATATG ATTGTTTTTT GTTGATTAGA CCAGAATAGT 540 TGTGTGTATT TGTTTTTTTG TTCTGAGAAC TATTGTCTGT TCTTTATTTT CATTCAGACA 600 ATATGAATGC TGTTTTGTAC AGATTCTTTT TGTTGTGATG TTCAGACAAT ATGAATCAGT 660 GGCTGTTTGT CTGTTTTTCA TTCAAAATTT TCAGAGTGCA CAAGTGTGTG TTGTTAATCC 720 AGAAATTTTC AGAGGATTGC TTGTTCTGTT CTGACCTGAA CTAGTAAAAA AACAAATTCA 780 GATTTGGTTC AATATTCAGA TTCTTGTTTT TGTAATCATT GCTGTGCAGA ATCTGTTTGT 840 ACTCCTGGTC ATTTAGATTT TTAGTCTGTG TGTTTGTTGT TCACTGAGTA TTTCCATTGG 900 GGGCGAGAGT CTCTTTTCTT CTATGCTTTT ATACAGAGGT TCCAAATCAA TTGCAGTGTT 960 GTGCAATATT CAGTGTTGTT CAGATCTATG TATATAGCTT CTGTTCTATT ATAATGCCTG 1020 CAGTAATCTG CTCATGTAAA TAACAGAAAC CCTGTGGGTA TTTTGCATAT TTAGGTACAA 1080 AATTCAAAGT TTGCAGAAAC AAATCTGTTG AGCATTATGT CTTCTAAACC ACTAAACAGT 1140 TTTTTTTCTG TGCTGATGTT TTTTTTCTGC CCTTTATGTG AATGTTTACT TCTCTCTAAT 1200 CTCTGTTTGG TTTTAATTCA TCAGAGGAGC TATTTTGCAA GAATAAATGT CAAAGAACAA 1260 CATGAAGAAA AGGAAGACTC AAAAATATGC TGCGGGTCAC AGGTACCTTT TGATTTGTGA 1320 TTTTCTTGAA TTTTGATCCC CAATATTTCT TGTTTTGAGT CTGATCTGGA AGAATCTTGC 1380 ACTTTTGATC CTTCTCCAAT TCTGAGTTTC TTTTCCTTCA TCTCCATCTT TTTCCCCAGT 1440 TTTCTTTCTT CTCTTCGATC GATCTGAGTT TACCTCTTCT TCTCTGTGTT TGTCTGGAAG 1500 AATTATTTTG CCTGTTTTGA TTACTCGTCA CGTGAATATG TCAGCGATCT TCTTGCATTG 1560 CAAGTTTTGT TGTCACGTGG GTTTGCTCCC TTCTTTTTGG GCTTCATTTG GGCTTTTTTT 1620 TGAGCTCATA ATCTGATTTT TTTTTTCTTT TCTTGTTTAC TAATTGAGCC TAAGTTGGGC 1680 CCTGAAAGAT TCGTTTTTTA GTTCTGTTGG TGTCAAAAAT CTGGGCTGTT GGATCAAAAT 1740 CTGTTGGCTG AAAAATTCGA CAGATTTGGA ACTCTATTTT CTGTTGACTG AAAGATTAGT 1800 TTTTTAGTTC TGCTGGAGTC AAAGTCTGGG CTGTTGGATC AAAATCTGTT GGCTGAAAAA 1860 TTCGACAGAT TTGGAACTCT ATTTTCTGTT GACTGAAAGA TTAGTTTTTT AGTTCTGCTG 1920 GAGTCAAAGT CTGGGCTGTT GGATCAAAAT CTGTTGGCTG AAAAATTCAA CAGATTAGGA 1980 ACTCTATTTT CTGTCGACTG AACAGTAGAC AGAGTTAAGC AGAAACGAAT ATCACAATTG 2040 CTATGTTCAT TGTCTTGCGT GAGCGCTTTT TCTTCTATCT GTCTGTCTAG TGCATGAGCT 2100 AAACCAAACA TCTCTCGCTC TTGCACCAAT ATTCTCTGCA TCTCTGCACA ATGATATCAC 2160 TCCCGTTATT GCTCTTCGTC CTGTTGTTCT CTGCGCTGCT GCTCTGCCCT TCGAGCAGCG 2220 ATGATGGTGA TGCTGCCGGC GACGAACTTG CGCTGCTCTC TTTCAAGTCA TCCCTGCGAT 2280 ACCAGGGGGG CTTGTCGCTG GCATCTTGGA ACACGTCCGG CCACGGCCAG CAGCACTGCA 2340 CATGGGTGGG TGTTGTGTGC GGCCGCCGGC ACCCACACAG GGTGGTCGAG CTGCGGCTGA 2400 ACTCGTCCGA CCTGTCCGGG ATCATCTCGC CGTCGCTGGG CAACCTGTCC TTCCTCAGGA 2460 CGCTGGACCT CAGCGACAAC CACCTGTCCG GCAAGATACC CTAGGAACTC AGCAGTCTCA 2520 GCAGGCTCCA ACAACTGGTA CTGAATTTCA ACAGCCTATC GGGTGAGATT CCAGCTGCTT 2580 TGGGCAATCT AACCAGTCTC TCGGTTCTTG AGCTGACTAA CAATACACTG TCTGGAGCAA 2640 TCCCTTCATC TCTGGGCAAA CTCACCAGCC TCACTGATCT TGCACTGGCT GAAAATATGC 2700 TGTCTAGTTC CATCCCTTCA TCTTTCGGCC AATTGCGCAG ATTATCTTTC CTTAGCTTAG 2760 CCTTTAACAA TTTAAGTGGA GCGATCCCAG ATCCTATTTG GAACATCTCC TCTCTCACCA 2820 TATTCGAAGT CATATCCAAC AAGCTAAGTG GTACACTGCC TACAAATGCA TTCAGTAATC 2880 TTCCTAGTCT GCAGGAGGTA TACATGTATT ACAACCAGTT TCATGGTCGT ATCCCGGCAT 2940 CGATAGGTAA TGCTTCCAAC ATCTCAATAT TTACCATTGG TTTTAACTCT TTTAGCGGTG 3000 TTGTTCCACC GGAGATTGGA AGCATGAGAA ATCTTCAGAG ACTAGAGCTT CCAGAAACTC 3060 TTTTGGAAGC TAAAGAAACA AATGATTGGA AATTCATGAC GGCATTGACA AATTGCTCCA 3120 ATCTACAAGA AGTGGAACTG GGAGGTTGTA AATTTGGTGG AGTCCTCCCT GATTCTGTTT 3180 CCAATCTTTC CTCTTCGCTT GTATCTCTCT CCATTAGAGA TAACAAAATT TCAGGGAGCT 3240 TACCTAGAGA TATCGGTAAT CTCGTTAATT TACAATATCT TTCTCTCGCT AATAACTCCT 3300 TGACAGGATC CCTTCCCTCT TCCTTCAGCA AGCTTAAAAA TTTACGTCGT CTCACTGTAG 3360 ATAACAACAA GTTAATTGGT TCTCTCCCAT TGACTATCGG TAATCTTACA CAACTAACTA 3420 ATATGGAGGT CCAATTTAAT GCCTTCGGTG GTACAATACC AAGCACACTT GGAAACCTGA 3480 CCAAGCTGTT TCAAATAAAT CTTGGCCACA ATAACTTTAT AGGGCAAATT CCCATTGAAA 3540 TATTTAGCAT TCCCGCACTC TCTGAAATTT TGGATGTGTC CCATAATAAC TTGGAGGGAT 3600 CAATACCAAA AGAAATAGGG AAACTTAAAA ATATTGTCGA ATTCCATGCT GATTCGAAAA 3660 AATTATCGGG TGAGATCCCT AGCACCATTG GTGAATGCCA ACTTCTGCAG CATCTTTTCC 3720 TGCAAAACAA TTTCTTAAAT GGTAGCATCC CAATAGCTCT GACTCAGTTG AAAGGTCTGG 3780 ACACACTTGA TCTCTCAGGT AACAATTTGT CAGGTCAGAT ACCTATGTCC TTAGGGGACA 3840 TGCCTCTGCT CCACTCGCTG AACCTTTCGT TCAACAGCTT CCACGGTGAA GTGCCAACCA 3900 ATGGTGTTTT TGCAAATGCT TCTGAAATTT ACATCCAAGG CAATGCCCTT ATTTGCGGTG 3960 GCATACCTGA ACTACATCTT CCGACGTGTT CCTTAAAATC AAGAAAGAAA AAGAAACATC 4020 AAATTCTGCT GTTAGTGGTT GTTATCTGTC TCGTTTCGAC ACTTGCCGTA TTTTCGCTAC 4080 TCTACATGCT TCTAACCTGT CATAAGAGAA TAAAGAAAGA AGTCCCTACA ACGACATCCA 4140 TGCAAGGCCA CCCAATGATC ACTTATAAGC AGCTGGTAAA AGCAACAGAT GGTTTTTCGT 4200 CAACCAATTT GGTGGGCTCT GGATCGTTTG GCTCTGTTTA CAGAGGAGAA TTTGATAGCC 4260 AAGATGGTGA AAGCCCAAGA CTTGTCGCCG TGAAGGTACT AAAGCTGGAA ACTCCAAAGG 4320 CACTCAAGAG TTTCACGGCC GAATGCGAAA CACTGTGAAA CACTCGACAC CGCAATCTTG 4380 TCAAGATAGT TACAATTTGC TCGAGCATCG ATAACAGAGG GAATGATTTC AAAGCAATTG 4440 TGTATGACTT CATGCCCAAT GGCAATCTGG AAGATTGGCT ACACCCTGAA ACAAATGATC 4500 AAGCAGAGCA AAGGCACTTG ACTCTGCATC AGAGAGTGAC CATACTACTT GATGTTGCCT 4560 GTGCATTGCA CTATCTTCAC CGCCATGGCC CTGAACCTGT TGTACACTGC GATATTAAAT 4620 CAAGCAATGT GCTGTTAGAT GCTGATATGG TAGCCCATGT TGGAGACTTT GGACTTGCAA 4680 GAGTACTTAT TGAGGGAAGC TCATTGATGC AACAGTCAAC AAGTTCGATG GGGATAAGGG 4740 GAACAATTGG TTACGCAGCA CCAGGTTAAG TCTAAACTGT TTATGTCTAC TTCCTATAAT 4800 CTTCTCTTTT TTGAGGTTTC TTCTCTCTAG TGTTTTATGA CTATGAAATA TTTTTTGCTA 4860 CTGGAAAACA AAGTATGGTG TCGGGAACAC TGCCTCGACA CCTGGAGATA TTTACAGTTA 4920 TGGAATTCTA GTGTTGAAAA CAGTAACCGG GAAGCGGCCG ACAGATAGTA CATTCAGAAC 4980 TGGATTGAGC CTCCGTCAGT ACGTTGAACC GGGTCTACAT GGTAGACTAA TGGATGTTGT 5040 TGACAGGAAG CTTGGTTTGG ATTCCGAGAA ATGGCTTCAG GCTCGAGATG TTTCGCCATG 5100 CAGCAGTATT AGTGAATGCC TTGTTTCACT GCTTAGACTT GGGTTGTCTT GCTCTCAGGA 5160 ATTGCCATCG AGTAGAATGC AAGCCGGAGA TGTCATCAAT GAACTGCGTG CCATCAAAGA 5220 GTCCCTCTCG ATGTCATCCG GCATGTGAAG ATGTTGGAGT ATTTCATTGT AATGTGATGT 5280 GTCTATCAGT ACCCTTCACA ACTGATTTCA TTCTGCCGTG GTATTTAGTT ATTTACAAGA 5340 GAGTCACTGA AGGGTGAGTG TGTGACTGCT TGGTTGTAGC TATTTCCTGA TCTGCCCATC 5400 AGATCATGTA TCTGTTCTAT TGTTGTATTT CTCATAATAA CCACACACCT AAGGGAGGGT 5460 TCGGCAGAGG AGATTGTGAG TTAGTTTGTT TTGTTTTCCA CGCGCACGCT TCCCGAACTA 5520 CTAAACGGTG TGTTTTTTGC AAAAAAATTT CTATATGAAA GTTGCTTTAA AAAATCATAT 5580 TAATCCATTT TTGAAGTTTA AAATAGTTTA TACTCAATTA ATCATGTACT AATGGCTCAC 5640 CTCGTTTTGT GTATCTTCCC AATCTTCTCT TTTCCCCTCC TCTCAAACTC ACCCTAAGTA 5700 CACAACACTG TATTTGTGTG ATTTCAATAT TGATGCATAT ATACCCATGC TATATGCTAG 5760 AATTATATAC AAAAATTTTG AGATGTCTGA AGTTAACAAT CAATCAGGGA GCGATTCACA 5820 CCAAACCGCG AAATCGACCT AATGAGCTAA TCTAATTGTA CAGGCTGCCT TTGCATGACA 5880 GTGCGATATT AAATAAGCCC AGCCCTTTTT AGCAAAGGAT GGGAGGGTCA ATGTTCTAGA 5940 (2) INFORMATION FOR SEQ ID NO:11: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 7204 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: join(1683..1758, 1771..2186, 2347..4352, 5147..5547) (D) OTHER INFORMATION: /product= “receptor kinase-like protein” /note= “Xa21 gene family member F” (ix) FEATURE: (A) NAME/KEY: misc_feature (B) LOCATION: 233..384 (D) OTHER INFORMATION: /note= “Gaigin-Ol1, transposon-like element” (ix) FEATURE: (A) NAME/KEY: misc_feature (B) LOCATION: 404..532 (D) OTHER INFORMATION: /note= “Gaigin-Ol2, transposon-like element” (ix) FEATURE: (A) NAME/KEY: misc_feature (B) LOCATION: 1080..1239 (D) OTHER INFORMATION: /note= “Tourist-Ol1, transposon-like element” (ix) FEATURE: (A) NAME/KEY: misc_feature (B) LOCATION: 6201..6583 (D) OTHER INFORMATION: /note= “Crackle, transposon-like element” (ix) FEATURE: (A) NAME/KEY: misc_feature (B) LOCATION: 6750..6956 (D) OTHER INFORMATION: /note= “Ds-rice3, transposon-like element” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11: AAGCTTTCTA AATTATTTAA CTCTAAGTCT GTTATTATCC CCAAGTACAT CATCATCATA 60 CATAATATTT CATATTCACG ACATCCTTAA GCTAGATGCT TTTGGCCATT CTCTTATCTT 120 TTTAAAGAAA TTCTCTCCCA ATTAAGATGA GAGTGTCTTC TAGCAATTTG CCAGTTTTTA 180 CAATGTCTTT GAGTCCTCAC ACATTTTCAT GATGTTACCA ATAAATTACG AACGCCGTGT 240 TTAGTTCTAA AGTTTTTCTT CAAACTTACA ACTTTTCAAT CGCATCAAAA CTTTCTCCTA 300 CACACACAAA CTTTCAACTT TTCCATCACA TCGTTCCAAT TTCAACCAAA CTTCCAATTT 360 TGGTATGAAC TAAACACAGC CGAAAACAAA ATTTGTGTGT TATGGCCCTG TTTAGATTCT 420 AACTTTTCCA TTACATCAAA CTTTCCTACA TACACGAACT TTCAACTTTT CCGTCACATC 480 GTTTCAATTT TTTAAAACTT CCAATTTTAA CGTGGAACTA AACACAACCT ATATAACGAA 540 ATTTGTCAAA AACTTAATGG TGAAAGTCAC ACCTCAAAGG AAGGGCGCGC CTCTAGTCAA 600 GAACATCAAT TAAAAAGGTA CACAGGTTGT ACTAGCTTGT TCATGTTTAA TCTTGCGTCT 660 GCGAGACGCT AAATCCATGC CAAACAAAAG TGCTTCTATA GAGATAATCA TAAGAATATG 720 GTTTGGGACC ATATCCAACT GCTCAGAAGA ATCTCGTTCG GAGGTGAAGG TTAAGATGTT 780 CACCTCTCCA CACATAAAAC AAAGCGATCT TTTTCGCATA ATTAATTAAG CATTAGATAA 840 AATAAACTTA AAAAATAAAT CAATATGATT TTTTTAGAAA AAAAATATAT ACACTAAGTA 900 TAAGCATTGT CAAGGAGGAA GAAACACACA CTTCCATATA GAGAGATAGA AACATAGCTA 960 TAGGTAGTGT CACTGAGTAT TTTTCATCAC GCATATGCAT ATAAAATTAG GGGGTGTTTA 1020 CATCCATAGG TGTAAAGTTT TGGCATGTTA TATCGAGTAT TACGTAGAAT GTCGTATTAG 1080 GTGTTCGGGC ACTAATAAAA AAATAATTAC AGAATCCGTT AGTAAACCGC GAGATAAATT 1140 TATTAAGCCT AATTAATCCA TCATTAACAA ATGTTTACCG TAGCACCACA TTGTCAAATC 1200 ATGGAGCAAT TAGGTTTAAA AGATTCGTCT CGCAAATTAG TCATAATCTG TGCAATTAGT 1260 TATTTTTAGA CTATATTTAA GACTTCGTAC AGGTGTTCAA ACGTTCGATG TGACATGGTG 1320 CAAAATTTTA GGGTGTCATC TAGACACTCC CTTAATTAGA AAGTTAGGAA GAGGCGGTAA 1380 AGAACGCAGC ATGACTGAAA CTTTGAAAAT TTGATAAGGT ACACCAACTG GAGTATCTTT 1440 TATTTTCATT GAAGACTTTG ACCAGAAGAG CTTGACCCGT TTTTCTTGGA GTAGCCAGTA 1500 ATGTTTCATT CTTTTCCTTT TGCTGGGACT TCTTTTTATT TTTTTTGACA GGAGCCATTT 1560 GTTGGGACTT GGGATCCCTT TACTGTTATA GGACCAGTGC TTGAATCCAA ACACTGCATT 1620 GATCAGCTCA GCTCATTGTA GCGCACTCCT CCGCATGCAT GGCGAGATCA CCAACGTCGG 1680 TCATGATCTC TTCTTTGCTG CTGCTGCTGT TGATCGGCCC AGCGAGCAGT GACGATGATG 1740 CTGCTGCTGC TGCTGCTCGT ACCAGTACAG GCGGCGTCGC CGGCGACGAA CTCGCGCTGC 1800 TCTCTTTCAA GTCATCCCTG CTACACCAGG GGGGCTTGTC GCTGGCATCT TGGAACACGT 1860 CCGGCCACGG CCAGCACTGC ACATGGGTGG GTGTTGTGTG CGGCCGCCGC CGCCGCCGGC 1920 ACCCACACAG GGTGGTGAAG CTGCTGCTGC GCTCGTCCAA CCTGTCCGGG ATCATCTCGC 1980 CGTCGCTGGG CAACCTGTCC TTCCTCAGGG AGCTGGACCT CAGCGACAAC TACCTCTCCG 2040 GCGAGATACC ACCGGAGCTC AGCCGTCTCA GCAGGCTTCA GCTGCTGGAG CTGAGCGGTA 2100 ACTCCATCCA AGGGAGCATC CCCGCGGCCA TTGGAGCATG CACCAAGTTG ACATCGCTAG 2160 ACCTCAGCCA CAACCAACTG AGATTGGTGC CAGCTTGAAA CATCTCTCGA ATTTGTACCT 2220 TCACACCAAT GGTTTGTCAG GAGAGATTCC ATCTGCTTTG GGCAATCTCA CTAGCCTTCA 2280 GTATTTTGAT TTGAGCTGCA ACAGATTATC AGGAGCTATA CCTTCATCGC TAGGGCAGCT 2340 CAGCAGCAGT CTATTGACTA TGAATTTGCG ACAGAACAAT CTAAGTGGGA TGATCCCCAA 2400 TTCTATCTGG AACCTTTCGT CTCTAAGAGC GTTTAGTGTC AGCGAAAACA AGCTAGGTGG 2460 TATGATCCCT ACAAATGCAT TCAAAACCCT TCACCTCCTC GAGGTGATAG ATATGGACAC 2520 TAACCGTTTC CATGGCAAAA TCCCTGCCTC AGTTGCTAAT GCTTCTCATC TGACACGGCT 2580 TCAGATTGAT GGCAACTTGT TCAGTGGAAT TATCACCTCG GGGTTTGGAA GGTTAAGAAA 2640 TCTCACAACA CTGTATCTCT GGAGAAATTT GTTTCAAACT AGAGAACAAG AAGATTGGGG 2700 GTTCATTTCT GACCTAACAA ATTGCTCCAA ATTACAAACA TTGGACTTGG GAGAAAATAA 2760 CCTGGGGGGA GTTCTTCCTA ATTCGTTTTC CAATCTTTCC ACTTCGCTTA GTTTTCTTGC 2820 ACTTGATTTG AATAAGATCA CAGGAAGCAT TCCAAAGGAT ATTGGCAATC TTATTGGCTT 2880 ACAACATCTC TATCTCTGCA ACAACAATTT CAGAGGGTCA CTTCCATCAT CGTTGGGCAG 2940 GCTTAGAAAC TTAGGCATTC TAGTCGCCTA CGAAAACAAC TTGAGCGGTT CGATCCCATT 3000 GGCCATAGGA AATCTTACTG AACTTAATAT CTTACTGCTC GGCACCAACA AATTCAGTGG 3060 TTGGATACCA TACACACTCT CAAACCTCAC AAACTTGTTG TCATTAGGCC TTTCAACTAA 3120 TAACCTTAGT GGTCCAATAC CCAGTGAATT ATTCAATATT CAAACACTAT CAATAATGAT 3180 CAATGTATCA AAAAATAACT TGGAGGGATC AATACCACAA GAAATAGGGC ATCTCAAAAA 3240 TCTAGTAGAA TTTCATGCAG AATCGAATAG ATTATCAGGT AAAATCCCTA ACACGCTTGG 3300 TGATTGCCAG CTCTTACGGT ATCTTTATCT GCAAAATAAT TTGTTATCTG GTAGCATCCC 3360 ATCAGCCTTG GGTCAGCTGA AAGGTCTCGA AACTCTTGAT CTCTCAAGCA ACAATTTGTC 3420 AGGCCAGATA CCCACATCCT TAGCAGATAT TACTATGCTT CATTCCTTGA ACCTTTCTTT 3480 CAACAGCTTT GTGGGGGAAG TGCCAACCAT TGGTGCTTTC GCAGATGCAT CCGGGATCTC 3540 AATCCAAGGC AATGCCAAAC TCTGTGGTGG AATACCTGAT CTACATCTGC CTCGATGTTG 3600 TCCATTACTA GAGAACAGAA AGCATTTTCC AGCTCTACCT ATTTCTGTTT CTCTGGTCGC 3660 AGCACTGGCC ATCCTCTCAT CACTCTACTT GCTTATAACC TGGAACAAGA GAACTAAAAA 3720 GGGAGCCCCT TCAAGAACTT CCATGAAAGG CCACCCATTG GTCTCTTATT CGCAGTTGGT 3780 AAAAGCAACA GATGGTTTCG CGCCGACCAA TTTGTTGGGT TCTGGATCAT TTGGCTCAGT 3840 ATACAAAGGA AAGCTTAATA TCCAAGATCA TGTTGCAGTG AAGGTACTAA AGCTTGAAAA 3900 TCCTAAGGCA CTCAAGAGTT TCACTGCCGA ATGTGAAGCA CTACGAAATA TGCGACATCG 3960 AAATCTTGTC AAGATAGTTA CAATTTGCTC GAGCATTGAT AACAGAGGGA ACGATTTCAA 4020 AGCAATTGTG TATGACTTCA TGCCCAACGG CAGTCTGGAA GATTGGATAC ACCCTGAAAC 4080 AAATGATCAA GCAGACCAGA GGCACTTGAA TCTGCATCGA AGAGTGACCA TACTACTTGA 4140 TGTTGCCTGT GCATTGGACT ATCTTCACCG CCATGGCCCT GAACCTGTTG TACACTGTGA 4200 TGTTAAATCA AGCAATGTGC TGTTAGATTC TGATATGGTA GCGCATGTTG GAGATTCTGG 4260 GCTTGCAAGA ATACTTGTTG ATGGGACCTC ATTGATACAA CAGTCAACAA GCTCGATGGG 4320 ATTTAGAGGG ACAATTGGCT ATGCAGCACC AGGTCAGCAA GTCCTTCCAG TATTTTGCAT 4380 TTTCTGATCT CTAGTGCTAT ATGAAATAGT TTTTACCTCT AGTGAAACTG ATGGAGAATA 4440 TAAGTAATTA ATTGAACTAA TTAAATTGCA CAAAAATAAG ATTATTTGCC ATATCTATTC 4500 AGATGCTAAA TATAGCTAGT TCATAGAGGT ACATATTTTT TTTATATAGG AATCTAGAGC 4560 TACTACACAC TCAAATCAAA TTATGGGTGT TTTCTGCTCT ACACTGCAAT ATGAAATGAT 4620 TATCAGAAGG ATCAAATTTG AGTAAATTTG TCAATTCTAC ATTTAAGAAA CACTTTTTTT 4680 TGTATGTACT AGTTATTACA ATTTTTTATT TCAAGAACTT GCATTGACCA TGAAAAGTAC 4740 TTGGTACTAC TTCTAATTCC CACATGGAGG TGGTGAAAAT AATATAGATA CAAAAACGAA 4800 GTATCATATG TTGTGTGATA TACTATAATC ACAATGAACA CAAACAGGAT TCGTACAAAA 4860 GTAATTGGCC ATCATAGCAA CTGATTGCTT GGGGTAACTG TATAGCACAA TCATACCAAA 4920 TTTCTTTAGA TATGTATTTG TAAATTAGAT TCTTAAAGTT AAATATGAAA TTTCATTGGT 4980 ATTTATGTTT CTTTATATAA TAAAAATTAA TCCAACCTTT ACATCTACCA TTTGTCCAGC 5040 CATCCTTGTT ATTTGTGATA TTTAACACGT AATTTTACAT AATTATACAT CCAAGTTCTT 5100 TTTATTTAAC ACTGGAAATT TGAAATCGTA TTTCCTACTC AAACAGAGTA TGGCGTCGGG 5160 CACATTGCAT CAACACATGG AGATATTTAC AGCTATGGAA TTCTAGTGCT GGAAATAGTA 5220 ACCGGGAAGC GGCCAACTGA CAGTACATTC AGACCCGATT TGGGCCTCCG TCAGTACGTT 5280 GAACTGGGCC TACATGGCAG AGTGACGGAT GTTGTTGACA CGAAGCTCAT TTTGGATTCT 5340 GAGAACTGGC TGAACAGTAC AAATAATTCT CCATGTAGAA GAATCACTGA ATGCATTGTT 5400 TCGCTGCTTA GACTTGGGTT GTCTTGCTCT CAGGATTTGC CATTGAGTAG AACGCCAACC 5460 GGAGATATCA TCGACGAACT GAATGCCATC AAACAGAATC TCTCCGGATT GTTTCCAGTG 5520 TGTGAAGGTG CGAGCCTCGA ATTCTGATGT TATGTCTTGT AATGTTTTAT TGCCACTAGT 5580 CTTCAGATTG GAATGCTCTT CCGATCAGAC TTCTTCAGTG GTATCTACCA CACGATCACT 5640 AAAGTCATCG TGGCTATTTC CTGATCCAGC ATATCTGATC ATGCATGTTC TGTGTTTTAT 5700 ACCTGTATTT TACTCTGAAT TGCCACACCT CAACCCTGCC TCTGTTTGTT TGGCATACAA 5760 AAGATAGTGA TGAGTATATT GTTTCAGGGG CTTCCTAGTT GGCGTGTGTG CTTACCGGCA 5820 CGCACGCAGC CCGAGGGTGG GTTTCTTTTT TTTTCCATTG TTATTCCGTT GCTTTTTTCC 5880 ACCACGGTAG ATTTTTTTTT TCTGGATTTC CATTTTTTCC GTTGTTTTTC TCTATCGCTT 5940 ATGCTGGCGG ATTTTTTTCC GTGGTTTTTT TTTCAAGACG AGTATATCTA ATGTAACTAA 6000 CATGTTACTT TTAGATAACG ATGGTTATTA AGATAAGATT TTTTTCTGGA AGATTTTTGT 6060 AAGTAAATGG TAAAAAATAT GGAAATGGAA ACGGAAATAG TTTTGCTGTT ATACCGATCG 6120 TTTCCATATT TACCGTATTC TTATAGAAAT TACCGTTTCT TATAATATGG TAATTACCGT 6180 ATTTCTAAAT ATGTTGATAT CGATTTTGCT ATATATTGCG ACAAATTTTC TCCCAAAAAT 6240 TTGATAGATG TAATTATAGT ACAATCGTAG TGTAATTACA CTGTAACTAT AGTGTAACTT 6300 GTATGTAACT TTCAAAAATC TCTCTGTAAT ATGTTATTTT GGTAAAATAG AGGTTGTGGG 6360 AACAAATCCT TACACATATG TGTGCGCTGT GATTTTCTTT CTTCCTCACC AAAACAAAAC 6420 TTATAATAGA TTTAACAATT CAAAATTACG TGAAACTTAT ACAAGTTACA CCGTAGTTAC 6480 ATGCAAGTTA CAGTGTAATT ACACTACGAT TGTACTATAA TTACATCTGT CAAATTTTTA 6540 GGAGAAAATT TGTCGACAAA TATATAGGTG ATCCCGTTGA TATTTATAGG GTATGTCTCT 6600 ACTTGACTCA CAGTTTAGAG ATTGATTGAC TATTTAATCA AATCCCTAAC TTGATTGCAC 6660 GGCTAAAATG GAGTTGATTT CTAATTTATA TAGTATAGAT TGAATTTATT CGTACATATA 6720 ACATACTTAT GTAAAGTTAA ATATATGTTT TCTATAGTTT AATGTTTCTG TATTTGTTAC 6780 CGGTTTTCGA TCTATACCGA CCATGTTTCC TTCAGTATTA TTCCGTTTCC GGTTTTCTGA 6840 TATTTCTGAT ATCGTTTTCG TTTCCGAGTT TACCGTTTTC GATTTCATTT CCGAGAAAAA 6900 TATGATTATG GAAATGGTTG AGGCTGTTTT CCGATCGTTT CCGACCGTTT TCTTCCCTAC 6960 CCGTAGCAAT AATATATAAT ATTTTATCTC TAATCTTTCT CTCTCTCATA TCAACGAATA 7020 TTCGCTAAGA GACTGCTATT AACAAGGCTT TTATATATAT ATATGTACAT ATATATATAT 7080 ATATATATAT ATATATAGAC ACACACACAT ACATACATAC ATACATACAT ATATATACAT 7140 ACATATACAT ATATATATAT GTATACATAC ATATACATAT ATATATATGT ATACATACAT 7200 ATAC 7204 (2) INFORMATION FOR SEQ ID NO:12: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1332 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (vi) ORIGINAL SOURCE: (A) ORGANISM: Oryza longistaminata (B) STRAIN: IRBB21 (viii) POSITION IN GENOME: (A) CHROMOSOME/SEGMENT: 11 (B) MAP POSITION: 11q, RG103 (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 1..1332 (D) OTHER INFORMATION: /note= “3′ flanking sequence of Xa21 gene family member F” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:12: GCCGTCGATC AATCATTTGG AAACGGCCCA CATCTTTTCC ATCTATATGC ATTCATGAAA 60 TACATGGTAT ATCCCATCGA TCGGACATCA CCTGTTAGCG CGTACGCCAT CGTCGTGATC 120 AACCTAGCTA GGGCAAACGT CCTCCGATCG CCACCATCAC CAATGAACAA GCTGCTGCGG 180 CCTCTCGGTG GCCTGAGGTT GCTCAACCGA GAAGAACATC CGTTCCGATG CTTCTCCTCC 240 TCCATCGATC TCGTCTTCCC AGGTCGCCGC CGCCGCCACA TGGCAACCAC CGTGACCCAC 300 CCGCCGCCGA CGGAATCCCG CTGGTTCGAC GGCGGCGGCC GCGACTGCTG ACCCGGCCTC 360 GGTGATGCTG GAACGTTGGG GCTGCCTCAG GGGCTCCACG CCGGCGAACG TCGCCGCCGA 420 CGACAACACC GCCGCGGAGT CCCGCACCTC CCGCGGCCAA CCCCTCCGCG TCGCCCTCGC 480 CCGCGCGTCG CCGCCGGCGA TCTCCTTCAT CTGCTTCGAT CGCGGGGATG ATGGCTACGT 540 CATCGCGGCT CACGGCGACT CTGTCCTCTT CCGGATGAGT TGGAACGACT ACTTCGTCTA 600 CATGGCCGCC GCCGGCAAGC CGCCGTCGCT GACGCTGCTC CCCGTCTGCG ACATCCCCAT 660 GAACGAGCGC TGCTGGGTCA GCAAGGACCG TTTCAACGAC AGCTTCCGCA CCACGGGCCG 720 GGTGTTCGAC CAGCAGGACA CCGGCATCCT GCGCCTCCGC GGCGGCGAGG AGGCGCCGCC 780 TCTAGTGGCG CAGCTCCAGA TCGCGCACGA GGCGCCGTTC GACACGGCCG AGCTCTGCGT 840 GCTCCGCCCC GGCCACGGCC ACGGCGAGTG GGAGCTCAAG ACGGCGGTGC CCATCGTCCA 900 CCACGACGGC GGCGGCGAAC GCCGCCATGG CCTGGAGATG TGGCAGGAGA CAACGTGGCC 960 GTCCCCGTCG GCGACCGCTT CATGTGCTGG GCCAACTACG ACCTCGCCAC CTTCCTCATC 1020 TGCGACATGG CGGCGGCGGA TCTCGACAAC CCCAAGCTCC TGTACGTTCC GCTGCCGGTG 1080 AACCAGTGCC ACCCAAGGGA GAGCGACTTC GACGACGACC ACCACCACGA CGAGCTGATT 1140 CCATGGGGAG TACTTCCGCA ACATCGTCGC CACCGGCGCC GACGGCGGCG ACGACATTGT 1200 GCGATTCGTC AGCATCCACA ACCGCTGCTG CTGCGGCGCG CCCGTGATAC ACAACCTGTG 1260 CGAACGCTCC AGCTCGGCGT TCATGGTGAA CATCTGGAAG CTTGCCTGCG GAACCCCCGC 1320 GCCCGCGACA GC 1332 (2) INFORMATION FOR SEQ ID NO:13: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 840 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 1..840 (D) OTHER INFORMATION: /note= “Xa21 gene from cassava” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13: TCA AGC AAC AAT TTG TCA GGT CAA ATC CCT GAA TTT TTG GCA GGG TTT 48 Ser Ser Asn Asn Leu Ser Gly Gln Ile Pro Glu Phe Leu Ala Gly Phe 1 5 10 15 AGT TTT ATA TAT CTT AAC TTA TCT TTC AAT AAT TTT GAA GGC AGA GTG 96 Ser Phe Ile Tyr Leu Asn Leu Ser Phe Asn Asn Phe Glu Gly Arg Val 20 25 30 CCA ACA GAT GGG ATA TTC AAG AAT GCA AGC ATT GTT TCA GTC ACA GGA 144 Pro Thr Asp Gly Ile Phe Lys Asn Ala Ser Ile Val Ser Val Thr Gly 35 40 45 AAC TCT AAG CTT TGT GGA GGC ATA CCT GAG TTT CAA CAG CCT GCA TGC 192 Asn Ser Lys Leu Cys Gly Gly Ile Pro Glu Phe Gln Gln Pro Ala Cys 50 55 60 AAC TTC AAA AGG TCT GAA AAA AGG AGA GTT AAG GTA ATT GTT GGT ATT 240 Asn Phe Lys Arg Ser Glu Lys Arg Arg Val Lys Val Ile Val Gly Ile 65 70 75 80 ATT GCA GGA GGT TTA GGA GCA ATT TTG GTG GTG TTG TCC TTT ATA TTT 288 Ile Ala Gly Gly Leu Gly Ala Ile Leu Val Val Leu Ser Phe Ile Phe 85 90 95 CTT TTG AGA TTA AGA AAG AAA AGT CAC AAA CCC AGT TCA TCC TAT TCA 336 Leu Leu Arg Leu Arg Lys Lys Ser His Lys Pro Ser Ser Ser Tyr Ser 100 105 110 GAA AAT TCA CTT TTG GAA CTT CCA AAA GTG TCA TAT AGA GAT CTC TAT 384 Glu Asn Ser Leu Leu Glu Leu Pro Lys Val Ser Tyr Arg Asp Leu Tyr 115 120 125 AAG GCC ACT GAT GGG TTC TCC TCA GAA AAT TTA ATT GGT ACT GGT AGT 432 Lys Ala Thr Asp Gly Phe Ser Ser Glu Asn Leu Ile Gly Thr Gly Ser 130 135 140 TTT GGG TCC GTA TAT AAA GGA ATT CTT GAT GAA GGT GGA CCA GTT GTT 480 Phe Gly Ser Val Tyr Lys Gly Ile Leu Asp Glu Gly Gly Pro Val Val 145 150 155 160 GCT GTT AAA GTG CTT AAC CTC CAG CAT CAT GGA GCA GCT AAG TCT TTC 528 Ala Val Lys Val Leu Asn Leu Gln His His Gly Ala Ala Lys Ser Phe 165 170 175 ATG GCT GAA TGT GAA GCC TTG AGA AAT ATC AGA CAC CGG AAT CTT GTA 576 Met Ala Glu Cys Glu Ala Leu Arg Asn Ile Arg His Arg Asn Leu Val 180 185 190 AAG ATA CTA ACT GCT TGT TCA GGT GTT GAT TAT CAA GGC AAT GAT TTC 624 Lys Ile Leu Thr Ala Cys Ser Gly Val Asp Tyr Gln Gly Asn Asp Phe 195 200 205 AAG GCA CTG GTT TAT GAG TAC ATG GAT AAT GGA AAC CTT GAG GAG TGG 672 Lys Ala Leu Val Tyr Glu Tyr Met Asp Asn Gly Asn Leu Glu Glu Trp 210 215 220 TTG CAT CTA CCA GTT TCA GCA GAT AGA AAT CAT GGG GAG CCT AAG AAT 720 Leu His Leu Pro Val Ser Ala Asp Arg Asn His Gly Glu Pro Lys Asn 225 230 235 240 CTA AAT CTT CTT CAG AGA GTA AAT ATT GCA ATT GAT GTT GCT TCT GCA 768 Leu Asn Leu Leu Gln Arg Val Asn Ile Ala Ile Asp Val Ala Ser Ala 245 250 255 ATT GAA TAT CTC CAT CAT CAT TGC GGA AAT CCA ATA GTT CAT TGT GAC 816 Ile Glu Tyr Leu His His His Cys Gly Asn Pro Ile Val His Cys Asp 260 265 270 CTT AAA TCA AGC AAT GTG CTG TTA 840 Leu Lys Ser Ser Asn Val Leu Leu 275 280 (2) INFORMATION FOR SEQ ID NO:14: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 280 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:14: Ser Ser Asn Asn Leu Ser Gly Gln Ile Pro Glu Phe Leu Ala Gly Phe 1 5 10 15 Ser Phe Ile Tyr Leu Asn Leu Ser Phe Asn Asn Phe Glu Gly Arg Val 20 25 30 Pro Thr Asp Gly Ile Phe Lys Asn Ala Ser Ile Val Ser Val Thr Gly 35 40 45 Asn Ser Lys Leu Cys Gly Gly Ile Pro Glu Phe Gln Gln Pro Ala Cys 50 55 60 Asn Phe Lys Arg Ser Glu Lys Arg Arg Val Lys Val Ile Val Gly Ile 65 70 75 80 Ile Ala Gly Gly Leu Gly Ala Ile Leu Val Val Leu Ser Phe Ile Phe 85 90 95 Leu Leu Arg Leu Arg Lys Lys Ser His Lys Pro Ser Ser Ser Tyr Ser 100 105 110 Glu Asn Ser Leu Leu Glu Leu Pro Lys Val Ser Tyr Arg Asp Leu Tyr 115 120 125 Lys Ala Thr Asp Gly Phe Ser Ser Glu Asn Leu Ile Gly Thr Gly Ser 130 135 140 Phe Gly Ser Val Tyr Lys Gly Ile Leu Asp Glu Gly Gly Pro Val Val 145 150 155 160 Ala Val Lys Val Leu Asn Leu Gln His His Gly Ala Ala Lys Ser Phe 165 170 175 Met Ala Glu Cys Glu Ala Leu Arg Asn Ile Arg His Arg Asn Leu Val 180 185 190 Lys Ile Leu Thr Ala Cys Ser Gly Val Asp Tyr Gln Gly Asn Asp Phe 195 200 205 Lys Ala Leu Val Tyr Glu Tyr Met Asp Asn Gly Asn Leu Glu Glu Trp 210 215 220 Leu His Leu Pro Val Ser Ala Asp Arg Asn His Gly Glu Pro Lys Asn 225 230 235 240 Leu Asn Leu Leu Gln Arg Val Asn Ile Ala Ile Asp Val Ala Ser Ala 245 250 255 Ile Glu Tyr Leu His His His Cys Gly Asn Pro Ile Val His Cys Asp 260 265 270 Leu Lys Ser Ser Asn Val Leu Leu 275 280 (2) INFORMATION FOR SEQ ID NO:15: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 2193 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 1..2193 (D) OTHER INFORMATION: /note= “DT4 Xa21 gene from maize” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:15: GGATCCCCGC GCAGCTTGGC CGGTCGTCTT CGCTCCAGCG CGTGCGCCTG GGAAGCAACA 60 TGCTCTCCGG GCCGATCCCG CCGTCGCTTG GCGGAATCGC CACGCTGACC CTGCTGGATG 120 TGTCAAGCAA CGAGCTCACG GTGGCATCCC AGCGGCGCTC GCTCAATGCA GGCAGCTCAG 180 CCTCATCATC GTCCTGAGCC ACAGCCGCCT GTCAGGGGCG GTTCCGGGCT GGCTGGGCTC 240 GCTGCCGCAG CTCGGCGAGC TGGCACTCTC CAACAACGAG TTCACCGGAG CAATCCCGAT 300 GCAGCTCAGC AACTGCTCCA AGCTCCTGAA GCTGTCCCTC GACAACAACC AGATCAATGG 360 AACAGTGCCG CCTGAACTCG GCGGCTTGGT GTCCCTCAAC GTACTGAATC TCGCACACAA 420 CCAGCTCTCA GGTCCGATTC CGACGACGGT CGCAAAGCTG AGCGGCCTCT ATGAGCTTAA 480 CCTGTCGCAG AATTACCTGT CCGGCCCGAT CCCTCCGGAT ATCGGCAAGT TGCAAGACTT 540 GCAGAGCCTG CTGGACTTGA GCAGCAACAA TCTCAGTGGC CACATCCCTG CATCGCTGCG 600 GCTCACTCCC CAAGCTGGAA AACCTGAACC TGTCCCACAA CGCTCTGGTC GGCGCGGTGC 660 CGTCCCAGCT CGCTGGAATG AGTAGCTTGG TGCAGCTGGA CCTGTCCAGC ACCAGCTGGA 720 AGGGAAGCTG GGCACCGAGT TCGGCCGGTG GCCGCAGGCC GCATTCGCTG ACAATACAGG 780 GCTCTGCGGT AGCCCCTTGA GAGGTTGCAG CAGCAGAAAC AGCCATTCGG CGCTGCACGC 840 GGCGACCATC GCGTTGGTGT CTGCGGTGGT CACGCTGTTG ATTGTCCTCC TGATCATTGC 900 GATTGCGCTG ATGGTGGTGC GCCGCAGGGC CCGGGGTTCA GGCGAGGTGA ACTGCACGGC 960 GTTCTTGTCG TCGAGCTCGG GCAGCGCAAA CCGGCAGCTC GTCGTCAAGG GCTCGGCGCG 1020 GCGGGAGTTC CGGTGGGAGG CGATCATGGA GGCCACGGCG AACCTGAGCG ACCAGTTCGC 1080 CATCGGGTCC GGCGGATCAG GCACGGTGTA CAGGGCGGAG CTGTCCACTG GCGAGACGGT 1140 TGCCGTGAAG AGGATAGCGC ACATGGACAG CGACATGCTG CTCCACGACA AGAGCTTCGC 1200 GCGGGAGGTC AAGATCCTGG GCCGCGTCCG TCACCGGCAC CTGGTCAAGC TGCTCGGCTT 1260 CGTCACGTCC CGCGAGTGCG GCGGCGGCGG CGGCATGCTC GTGTACGAGC ACATGGAGAA 1320 CGGCAGCCTC TACGACTGGC TGCACGGCGG CAGCGATGGC CGGAAGAAGC GGACGCTCAG 1380 CTGGGAAGCG CGGCTCATGG TTGCCGCCGG GCTGGCGCAG GGCGTGGAGT ATCTCCACCA 1440 CGACTGTGTG CCCCGCATCG TGCACCGGGA CATCAAGTCC AGCAATGTGC TCCTCGACGG 1500 CGACATGGAG GCGCACCTCG GCGACTTCGG CCTCGCCAAG GCCGTCGCCG AGAACCGGCA 1560 GGCCGCCTTC GATAAAGACT GCACCGAGTC AGCTTCCTTC TTCGCCGGAT CATACGGGTA 1620 CATCGCTCCA GGTAATTTCG ACGGCAATCT GAAATGCTAT AGAAACGCAG TAGCTCAGGC 1680 GACGCGGCCA GTTACTGACA GTGGACGTGC CACATTATCT CTGCAGATGT GCTTACTCCC 1740 TGGAGGCGAC GGAGAGAAGC GACGTCTACA GCATGGGCAT CGTGGTTATG GAGCTCGTCA 1800 CCGGGCTCTT GCCGACCGAC AAACCTTCGG CGGCGAACAT GACATGGTGA GGTGGGTGCA 1860 GTCGAGGATG GACGCGCCGT TGCCAGCAAG GGAGCAGGTG TTCGATCCTG CTCTGAAGCC 1920 GCTGGCGCCG CGTGAGGAGT CGTCGATGAC GGAGGTGCTG GAAGTGGCGC TCCGGTGCAC 1980 AAGGGCTGCT TCACGTTTCA CTCGATTACT GACGCGTCTG CGAGATGAAT TAGGCTTTGT 2040 TCGTTTGTGT CGGAGTCGAG TGTAATCCAA CACAAACAAG ACCTTAGGAT TTGAAAAGTG 2100 GGCTGGATTG TCTTAGCAGC CGCTCAAAAT TGGATCGCTT AATTTCAAAT TTTGAGCTCC 2160 CTTGTACAAT CATCATTTGG AAATGTCCAG CAG 2193 (2) INFORMATION FOR SEQ ID NO:16: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3045 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: cDNA (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 1..3045 (D) OTHER INFORMATION: /note= “DM4 Xa21 gene from maize cDNA clone” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16: GGCACGAGGG GAACTAGACA TGTCTGGGAA CAAGATTCTG TCGGGCCGAG TACCGGAGTT 60 CCTGGGGGGC TTCCGAGCAT TGCGGCGACT CGGACTTGCC GGGAACAACT TCACCGAGGA 120 AATCCCGGAT GAGCTGAGCC TCCTGTGCGG AACGCTGGTT CAGCTAGACT TGTCAAGCAA 180 CCAATTGGTT GGCGGTTTGC CAGCGAGCTT CTCAGGATGC AGATCGCTTG AGGTGCTCGA 240 TCTGGGTAGC AACCAGCTGT CAGGTGACTT TGTGATCACT GTGATCAGCA AGATCTCTTC 300 TCTGCGTGTG CTGAGGCTGC CGTTCAACAA TATCACAGGC ACAAATCCTC TGCCCACGCT 360 AGCAGCTGGC TGCCCTTTGC TTGAAGTCAT TGATCTCGGG TCTAACATGC TGGAANGAGA 420 GATCATGCCC GAGCTGTGTT CATCTTTGCC ATCACTCAGA AAGCTGCTCC TACCCAACAA 480 CTACATCAAT GGAACCGTGC CGCCCTCACT CGGCAACTGC AGTAATCTGG AGTCACTGGA 540 CCTCAGCTTC AACCTCATGG TTGGTCCGAT CACCCTGAAG TACTGTTGCT TCCTAAACTT 600 GTTGAATTGG TCATGTGGGC AAACANTCTC TCCGGTGAAA TACCAAACAC GCNATGCTCC 660 ACAGCACAAC ACTGAAAANC CGTCNTAAAC TACAACAACA TAACCGAATG ATCCCGTTCN 720 CNTCNCCAGT NGCTNAATCC ATATGGTGTC CTTCCGGCAA CACATAACGG GAATNNNNNN 780 NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 840 NNNNNNNNNN NNNNNNNNNN NNNNGGATCC TNTTTCNTNA CAGNGGGGAT TTTTATATGG 900 TGTAATTGCG GCAACGGATG ACGGGGTNTC CCGCGGTTTG GGACCTTCCA GAGTTTGCCA 960 TTTACAGTGC ACAGGAATTC ATTTTTTGTT CCTGTGCCAG CAGAGNTTGT TCGCTGCAGC 1020 ACCTTATNTG GTTGATTTTC AACAGCAACA ATTTTTCCGG TGCGATACCG CCGCAGTTAG 1080 CAGCAACAGG CAGGGNTCAT CACTGGAGGC ATGGTTTTCT GGGAAGCAGT TCGCGTTCCT 1140 GAGGAATGAG GCTGGAACAT CTGCCCAGGT GCTGGAGTGC TGTTCGAGTT CTTTGACATC 1200 CGTCCGGAGC GGCTGGCCCA GTTCCCTGCT GTGCACTCGT GTGCCTCCAC GAGGATATAC 1260 ACTGGGATGA CAGTGTACAC CTTCAACCAA AGTGGGAGCA TGATATTCCT TGATCTCTCG 1320 TACAACAGCC TCACAGGCAC AATTCCGGCG AGCCTGGGGA ACATGACGTA TCTTGATGTC 1380 CTTAACCTGG GGCATAATGA CCTTACCGGT GCAATTCCAG ATGCGTTCAC AGGGTTGAAG 1440 GCGATTGGTG TCCTTGACCT NTCGCACAAT CACCTCACCG GTGTCATCCC TGCTGGACTG 1500 GGGTGTTTAA ATTTCCTAGC TGACTTCGAC GTCTCCAACA ACAACCTCAC TGGTGAGATA 1560 CCCACGTCAG GGCAGCTCAG TACATTTCCA GCATCCCGTT TTGAGAACAA CTCCGGCATC 1620 TGTGGCATCC CCTTGGATCC TTGCACGCAC AATGCCAGCA CTGGAGGTGT TCCTCAAAAC 1680 CCCTCTAACG TGCGGAGGAA GTTTCTCGAA GAGTTCGTGC TCCTTGCAGT GTCGCTCACC 1740 GTGCTCATGG TGGCCACCTT GGTTGTCACT GCATACAAGC TCAGGAGGCC CCGTGGGAGC 1800 AAAACTGAAG AGATTCAAAC TGCTGGGTAT AGCGACAGCC CCGCATCGTC CACCAGTACA 1860 AGCTGGAAGC TTTCTGGTTC CAAAGAGCCA CTGAGCATCA ATCTGGCGAT ATTTGAGAAT 1920 CCGTTGAGGA AACTAACATA TGCCCACCTG CATGAGGCTA CCAATGGCTT CAGCTCGGAA 1980 GCTCTTGTTG GCACAGGAGG ATTCGGTGAG GTTTACAAGG CTAGGCTCAT GGATGGCAGC 2040 GTTGTGGCTG TCAAGAANCT GATGCATTTC ACAGGCCAAG GCGACCGGGA GTTCACTGCA 2100 GAGATGGAGA CCATTGGCAA GATCAAACAT CGCAACCTTG TGCCGTTGCT AGGCTACTGC 2160 AAAGTTGGCG ACGAACGTCT GCTTGTGTAC GAGTACATGA ATAATGGAAG CCTGGATGTC 2220 TTGCTCCATG AAAGGGACAA GACTGATGTG GGTCTTGATT GGGCAACAAG GAAGAAGATT 2280 GCAGTTGGCT CGGCAAGAGG ACTGGCCTTC CTCCACCATA GTTGCATCCC ACACATCATA 2340 CACCGGGACA TGAAGTCAAG CAACGTGCTT CTTGACGATA ATCTCGATGC CTACGTATCG 2400 GATTTCGGAA TGGCGCGGCT CGTGAATGCT GTTGACTCAC ATCTAACCGT GAGCAAGCTC 2460 TTAGGAACAC CTGGTTATGT GGCTCCCGAG TACTTCCAGT CGGTTATTTG CACAACTAAG 2520 GGCGACGTCT ACAGCTATGG CGTTGTTCTT CTGGAGCTTC TCTCAGGGAA AAAACCAATC 2580 AATCCGACTG AATTCGGCGA CAATAATCTC ATCGACTGGG CCAAGCAGAT GGTTAAGGAG 2640 GACCGGTGCA GCGAGATATT TGATCCTATA TTGACCGACA CAAAATCCTG CGAGTCGGAG 2700 CTGTACCAGT ATCTGGCGAT TGCTTGCCAG TGCTTGGACG ATCAACCTAG TCGCAGACCT 2760 ACGATGATCC AGGTCATGGC AATGTTCAGT GAGTTTCAGA TTGACTCTGG CAGCTTCTTC 2820 TTGGACGGCT TCTCGCTCGA TTCAGATAGA GGAATCATCT GAAAAAAAAT GTGTAAATGT 2880 TATTGATCCC TGCAGATTAT ATGATTCACT GGATTTAGGT ATTAGCTTAG CCATGTTTAA 2940 CTCATGTTAA CAGGATACAA ACAGATGTAA ATTTGTTTCG GTTGCCGTAC ATAGTACACA 3000 ACAGCTTCAA CACAGATACC ATATAGAGTT GTTTCCAAAA AAAAA 3045 (2) INFORMATION FOR SEQ ID NO:17: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3293 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 1..3293 (D) OTHER INFORMATION: /note= “TRK1 Xa21 gene from tomato” (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 92..2974 (D) OTHER INFORMATION: /product= “TRK1” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:17: ATCGGGCAGG TCTTCAAAAT ACTTGTTACA TCTTCTTCTT ACCTTTGATA TTTTCCAAAG 60 TATTTGTAAC TTCAAATCAC TAGTTATCTA A ATG GCT ACT TCT AAC ACA AGT 112 Met Ala Thr Ser Asn Thr Ser 1 5 CTC TTG TTT TTC GCG TAT TTC CTC CTT GTG TTC CTT ATT ACT CCA TCT 160 Leu Leu Phe Phe Ala Tyr Phe Leu Leu Val Phe Leu Ile Thr Pro Ser 10 15 20 CAA TCG CGT AAC CTG TCT CTG AGA CGA CAG GCT AAA ACT CTA GTT TCA 208 Gln Ser Arg Asn Leu Ser Leu Arg Arg Gln Ala Lys Thr Leu Val Ser 25 30 35 TTG AAA TAT GCA TTT GTA CAA TCA TCT GTT CCT AGT ACT CTG TCC AAT 256 Leu Lys Tyr Ala Phe Val Gln Ser Ser Val Pro Ser Thr Leu Ser Asn 40 45 50 55 TGG AAC ATG TCG AAT TAT ATG TCT ATA TGT TCT TGG ACA GGT ATA ACG 304 Trp Asn Met Ser Asn Tyr Met Ser Ile Cys Ser Trp Thr Gly Ile Thr 60 65 70 TGT GAT GAT ACC AAA TCA GTA ACT TCC ATT GAT ATA TCC AAT CTA AAC 352 Cys Asp Asp Thr Lys Ser Val Thr Ser Ile Asp Ile Ser Asn Leu Asn 75 80 85 ATT TCT GGC TCT TTA TCA CCT GAT ATT CAT GAG CTC ACT AGA CTT CGC 400 Ile Ser Gly Ser Leu Ser Pro Asp Ile His Glu Leu Thr Arg Leu Arg 90 95 100 GTC CTG AAT ATT TCT AAC AAT TTG TTT AGT GGA AAC TTA AGC TGG GAG 448 Val Leu Asn Ile Ser Asn Asn Leu Phe Ser Gly Asn Leu Ser Trp Glu 105 110 115 TAT CGC GAG TTT AAT GTA CTT CAA GTG TTG GAT GCT TAT AAC AAC AAT 496 Tyr Arg Glu Phe Asn Val Leu Gln Val Leu Asp Ala Tyr Asn Asn Asn 120 125 130 135 TTC TCT GGT CCA CTC CCT TTG GGA GTT ACT CAA CTT GTG CAG CTC AAG 544 Phe Ser Gly Pro Leu Pro Leu Gly Val Thr Gln Leu Val Gln Leu Lys 140 145 150 TAC TTG AAT TTC GGG GGT AAC TAC TTT TCA GGG AAG ATT CCT TTG AGT 592 Tyr Leu Asn Phe Gly Gly Asn Tyr Phe Ser Gly Lys Ile Pro Leu Ser 155 160 165 TAT GGT AGT TTT AAT CAG CTT GAG TTC CTG TCT CTT GCT GGG AAT GAC 640 Tyr Gly Ser Phe Asn Gln Leu Glu Phe Leu Ser Leu Ala Gly Asn Asp 170 175 180 TTG CAC GGT CCT ATA CCG AGG GAG CTG GGG AAC GTT ACG AGC CTC AGG 688 Leu His Gly Pro Ile Pro Arg Glu Leu Gly Asn Val Thr Ser Leu Arg 185 190 195 TGG TTA CAG TTG GGT TAT TAT AAT CAA TTT GAT GAG GGG ATT CCA CCA 736 Trp Leu Gln Leu Gly Tyr Tyr Asn Gln Phe Asp Glu Gly Ile Pro Pro 200 205 210 215 GAG TTG GGG AAA CTT GTT AAT TTG GTT CAT CTA GAT CTT TCA AGC TGT 784 Glu Leu Gly Lys Leu Val Asn Leu Val His Leu Asp Leu Ser Ser Cys 220 225 230 AAC TTA ACG GGT TCG ATT CCA CCA GAA TTG GGC AAT CTT AAT ATG TTG 832 Asn Leu Thr Gly Ser Ile Pro Pro Glu Leu Gly Asn Leu Asn Met Leu 235 240 245 GAC ACT CTT TTC TTG CAA AAG AAT CAA CTT ACT GGT GTA TTT CCT CCT 880 Asp Thr Leu Phe Leu Gln Lys Asn Gln Leu Thr Gly Val Phe Pro Pro 250 255 260 CAG CTA GGG AAT TTG ACA AGG TTA AAA TCT CTT GAT ATC TCG GTC AAT 928 Gln Leu Gly Asn Leu Thr Arg Leu Lys Ser Leu Asp Ile Ser Val Asn 265 270 275 GAA CTC ACA GGA GAG ATC CCG GTT GAC TTG TCA GGA CTC AAG GAG CTC 976 Glu Leu Thr Gly Glu Ile Pro Val Asp Leu Ser Gly Leu Lys Glu Leu 280 285 290 295 ATA TTG TTG AAC CTC TTT ATC AAC AAT TTG CAC GGT GAG ATT CCA GGA 1024 Ile Leu Leu Asn Leu Phe Ile Asn Asn Leu His Gly Glu Ile Pro Gly 300 305 310 TGT ATC GCG GAG CTG CCA AAG TTG GAA ATG TTG AAT CTT TGG AGG AAT 1072 Cys Ile Ala Glu Leu Pro Lys Leu Glu Met Leu Asn Leu Trp Arg Asn 315 320 325 AAT TTC ACT GGC TCG ATT CCT TCT AAG CTT GGG ATG AAC GGT AAA CTA 1120 Asn Phe Thr Gly Ser Ile Pro Ser Lys Leu Gly Met Asn Gly Lys Leu 330 335 340 ATT GAA ATT GAT CTG TCT AGT AAT AGA CTC ACT GGC TTG ATA CCA AAA 1168 Ile Glu Ile Asp Leu Ser Ser Asn Arg Leu Thr Gly Leu Ile Pro Lys 345 350 355 TCT CTA TGC TTT GGG AGG AAT TTG AAA ATC TTG ATT CTT CTT GAT AAT 1216 Ser Leu Cys Phe Gly Arg Asn Leu Lys Ile Leu Ile Leu Leu Asp Asn 360 365 370 375 TTT CTG TTT GGA CCT TTA CCT GAT GAT TTT GGG CAG TGT CGA ACG TTG 1264 Phe Leu Phe Gly Pro Leu Pro Asp Asp Phe Gly Gln Cys Arg Thr Leu 380 385 390 TCC AGA GTC AGA ATG GGA CAG AAT TAC TTG AGT GGA TCA ATA CCA ACA 1312 Ser Arg Val Arg Met Gly Gln Asn Tyr Leu Ser Gly Ser Ile Pro Thr 395 400 405 GGG TTT CTT TAT TTG CCT GAG TTG TCA CTG GTG GAA CTG CAG AAC AAC 1360 Gly Phe Leu Tyr Leu Pro Glu Leu Ser Leu Val Glu Leu Gln Asn Asn 410 415 420 TAC ATC AGT GGA CAA CTC TGG AAC GAG AAA AGC TCA GCG TCT TCT AAA 1408 Tyr Ile Ser Gly Gln Leu Trp Asn Glu Lys Ser Ser Ala Ser Ser Lys 425 430 435 CTT GAA GGG CTG AAC CTG TCG AAC AAT CGC TTG TCT GGT GCA CTT CCT 1456 Leu Glu Gly Leu Asn Leu Ser Asn Asn Arg Leu Ser Gly Ala Leu Pro 440 445 450 455 AGT GCT ATT GGA AAC TAT TCA GGG CTG AAG AAT CTT GTG TTA ACT GGA 1504 Ser Ala Ile Gly Asn Tyr Ser Gly Leu Lys Asn Leu Val Leu Thr Gly 460 465 470 AAT GGT TTC TCA GGT GAT ATC CCT TCT GAT ATT GGC AGA CTA AAG AGC 1552 Asn Gly Phe Ser Gly Asp Ile Pro Ser Asp Ile Gly Arg Leu Lys Ser 475 480 485 ATC TTA AAG CTG GAC CTG AGT AGA AAC AAC TTC TCT GGC ACA ATC CCT 1600 Ile Leu Lys Leu Asp Leu Ser Arg Asn Asn Phe Ser Gly Thr Ile Pro 490 495 500 CCT CAG ATT GGT AAC TGT CTT TCC TTA ACT TAC TTG GAT TTG AGC CAA 1648 Pro Gln Ile Gly Asn Cys Leu Ser Leu Thr Tyr Leu Asp Leu Ser Gln 505 510 515 AAT CAA CTT TCT GGT CCT ATC CCA GTT CAA ATT GCT CAA ATT CAC ATC 1696 Asn Gln Leu Ser Gly Pro Ile Pro Val Gln Ile Ala Gln Ile His Ile 520 525 530 535 TTA AAT TAC ATC AAT ATT TCC TGG AAT CAC TTC AAC GAG AGC CTT CCC 1744 Leu Asn Tyr Ile Asn Ile Ser Trp Asn His Phe Asn Glu Ser Leu Pro 540 545 550 GCG GAG ATT GGC TTG ATG AAG AGT TTA ACT TCA GCA GAT TTT TCC CAC 1792 Ala Glu Ile Gly Leu Met Lys Ser Leu Thr Ser Ala Asp Phe Ser His 555 560 565 AAT AAC TTA TCT GGA TCA ATA CCT GAA ACA GGC CAA TAT TTA TAT TTC 1840 Asn Asn Leu Ser Gly Ser Ile Pro Glu Thr Gly Gln Tyr Leu Tyr Phe 570 575 580 AAC TCA ACT TCC TTC ACC GGC AAC CCT TAT CTC TCT GGA TCC GAC TCG 1888 Asn Ser Thr Ser Phe Thr Gly Asn Pro Tyr Leu Ser Gly Ser Asp Ser 585 590 595 ACT CCT AGC AAC ATT ACA TCC AAC TCA CCG TCA GAA CTT GGA GAC GGA 1936 Thr Pro Ser Asn Ile Thr Ser Asn Ser Pro Ser Glu Leu Gly Asp Gly 600 605 610 615 AGT GAC AGC AGA ACT AAG GTT CCT ACA ATA TAC AAG TTC ATA TTT GCA 1984 Ser Asp Ser Arg Thr Lys Val Pro Thr Ile Tyr Lys Phe Ile Phe Ala 620 625 630 TTT GGG CTC TTA TTC TGC TCC CTC ATT TTC GTT GTC TTA GCA ATA ATC 2032 Phe Gly Leu Leu Phe Cys Ser Leu Ile Phe Val Val Leu Ala Ile Ile 635 640 645 AAG ACA AGA AAG GGG AGT AAG AAT TCA AAT TTG TGG AAG CTG ACA GCA 2080 Lys Thr Arg Lys Gly Ser Lys Asn Ser Asn Leu Trp Lys Leu Thr Ala 650 655 660 TTT CAG AAG CTT GAG TTC GGA AGT GAA GAC GTC TTG CAG TGC TTG ATA 2128 Phe Gln Lys Leu Glu Phe Gly Ser Glu Asp Val Leu Gln Cys Leu Ile 665 670 675 GAC AAC AAC GTC ATA GGG AGA GGT GGA GCA GGG ATA GTG TAT AAG GGA 2176 Asp Asn Asn Val Ile Gly Arg Gly Gly Ala Gly Ile Val Tyr Lys Gly 680 685 690 695 ACT ATG CCA AAT GGT GAT CAT GTC GCG GTG AAG AAA TTG GGA ATA AGC 2224 Thr Met Pro Asn Gly Asp His Val Ala Val Lys Lys Leu Gly Ile Ser 700 705 710 AAA GGC TCA CAT GAT AAC GGC CTA TCT GCT GAA CTT AAC ACA TTA GGG 2272 Lys Gly Ser His Asp Asn Gly Leu Ser Ala Glu Leu Asn Thr Leu Gly 715 720 725 AAG ATC AGG CAT AGG TAC ATT GTG AGA CTG CTC GCG TTT TGT TCA AAC 2320 Lys Ile Arg His Arg Tyr Ile Val Arg Leu Leu Ala Phe Cys Ser Asn 730 735 740 AAG GAA GTC AAC TTG CTA GTT TAT GAG TAC ATG CTA AAT GGA AGC TTA 2368 Lys Glu Val Asn Leu Leu Val Tyr Glu Tyr Met Leu Asn Gly Ser Leu 745 750 755 GGT GAA GTG CTT CAT GGG AAG AAC GGC GGG CAA CTC CAA TGG GAA ACT 2416 Gly Glu Val Leu His Gly Lys Asn Gly Gly Gln Leu Gln Trp Glu Thr 760 765 770 775 AGG CTA AAA ATA GCC ATA GAA GCT GCC AAG GGC CTT TCT TAT TTG CAC 2464 Arg Leu Lys Ile Ala Ile Glu Ala Ala Lys Gly Leu Ser Tyr Leu His 780 785 790 CAC GAT TGC TCC CCT ATG ATA ATC CAC CGC GAT GTC AAG TCC AAC AAT 2512 His Asp Cys Ser Pro Met Ile Ile His Arg Asp Val Lys Ser Asn Asn 795 800 805 ATA TTG TTG AAC TCT GAA CTT GAA GCT CAT GTT GCA GAT TTT GGA TTA 2560 Ile Leu Leu Asn Ser Glu Leu Glu Ala His Val Ala Asp Phe Gly Leu 810 815 820 GCC AAG TAC TTT CGT AAC AAT GGT ACC TCT GAG TGC ATG TCT GCA ATT 2608 Ala Lys Tyr Phe Arg Asn Asn Gly Thr Ser Glu Cys Met Ser Ala Ile 825 830 835 GCA GGA TCT TAT GGC TAC ATT GCT CCA GAA TAT GCA TAC ACG CTG AAA 2656 Ala Gly Ser Tyr Gly Tyr Ile Ala Pro Glu Tyr Ala Tyr Thr Leu Lys 840 845 850 855 ATT GAT GAG AAA AGC GAT GTG TAT AGC TTT GGA GTG GTG TTG TTG GAG 2704 Ile Asp Glu Lys Ser Asp Val Tyr Ser Phe Gly Val Val Leu Leu Glu 860 865 870 CTT ATA ACA GGA CGA AGG CCA GTA GGA AAT TTT GGA GAA GAA GGA ATG 2752 Leu Ile Thr Gly Arg Arg Pro Val Gly Asn Phe Gly Glu Glu Gly Met 875 880 885 GAC ATT GTA CAA TGG GCG AAA ACG GAG ACA AAA TGG AGC AAA GAA GGG 2800 Asp Ile Val Gln Trp Ala Lys Thr Glu Thr Lys Trp Ser Lys Glu Gly 890 895 900 GTG GTG AAA ATC TTG GAT GAG AGG CTA AAA AAT GTT GCA ATT GTT GAA 2848 Val Val Lys Ile Leu Asp Glu Arg Leu Lys Asn Val Ala Ile Val Glu 905 910 915 GCT ATG CAA GTA TTT TTT GTA GCA ATG CTT TGT GTT GAA GAG TAC AGC 2896 Ala Met Gln Val Phe Phe Val Ala Met Leu Cys Val Glu Glu Tyr Ser 920 925 930 935 ATT GAG AGG CCT ACA ATG AGG GAA GTA GTC CAA ATG CTT TCT CAA GCT 2944 Ile Glu Arg Pro Thr Met Arg Glu Val Val Gln Met Leu Ser Gln Ala 940 945 950 AAA CAA CCA AAT ACT TTC CAA ATC CAA TAATCTAATT GTGGCTCTAC 2991 Lys Gln Pro Asn Thr Phe Gln Ile Gln 955 960 TTATTGTATG CTTGGGAACA CCCCTTTTGT TAGCTTTGCA AAAGTGAAAT CACAAATTAA 3051 TCTAAGTGAA GTAGTTGCAA AATTAATTTG CAATTATGTT AGATCTTAGG GTATGATATC 3111 TAACTATATC CTCTCAACTT GGAATAGTGT ATTGGATGTG TAGAACTAGT ATTAGTATCC 3171 GCGTGATGTG TGGCGAATAT CAAAAGAAAG TCGACRCAKR MMRCTAATYC CKCYGWTWCW 3231 RAMGKMSWCC MGGMSKCGAW YKCCRCCRAT ACTGACGGAC TCCAGGAGTC GTCGCCACCA 3291 AT 3293 (2) INFORMATION FOR SEQ ID NO:18: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 960 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18: Met Ala Thr Ser Asn Thr Ser Leu Leu Phe Phe Ala Tyr Phe Leu Leu 1 5 10 15 Val Phe Leu Ile Thr Pro Ser Gln Ser Arg Asn Leu Ser Leu Arg Arg 20 25 30 Gln Ala Lys Thr Leu Val Ser Leu Lys Tyr Ala Phe Val Gln Ser Ser 35 40 45 Val Pro Ser Thr Leu Ser Asn Trp Asn Met Ser Asn Tyr Met Ser Ile 50 55 60 Cys Ser Trp Thr Gly Ile Thr Cys Asp Asp Thr Lys Ser Val Thr Ser 65 70 75 80 Ile Asp Ile Ser Asn Leu Asn Ile Ser Gly Ser Leu Ser Pro Asp Ile 85 90 95 His Glu Leu Thr Arg Leu Arg Val Leu Asn Ile Ser Asn Asn Leu Phe 100 105 110 Ser Gly Asn Leu Ser Trp Glu Tyr Arg Glu Phe Asn Val Leu Gln Val 115 120 125 Leu Asp Ala Tyr Asn Asn Asn Phe Ser Gly Pro Leu Pro Leu Gly Val 130 135 140 Thr Gln Leu Val Gln Leu Lys Tyr Leu Asn Phe Gly Gly Asn Tyr Phe 145 150 155 160 Ser Gly Lys Ile Pro Leu Ser Tyr Gly Ser Phe Asn Gln Leu Glu Phe 165 170 175 Leu Ser Leu Ala Gly Asn Asp Leu His Gly Pro Ile Pro Arg Glu Leu 180 185 190 Gly Asn Val Thr Ser Leu Arg Trp Leu Gln Leu Gly Tyr Tyr Asn Gln 195 200 205 Phe Asp Glu Gly Ile Pro Pro Glu Leu Gly Lys Leu Val Asn Leu Val 210 215 220 His Leu Asp Leu Ser Ser Cys Asn Leu Thr Gly Ser Ile Pro Pro Glu 225 230 235 240 Leu Gly Asn Leu Asn Met Leu Asp Thr Leu Phe Leu Gln Lys Asn Gln 245 250 255 Leu Thr Gly Val Phe Pro Pro Gln Leu Gly Asn Leu Thr Arg Leu Lys 260 265 270 Ser Leu Asp Ile Ser Val Asn Glu Leu Thr Gly Glu Ile Pro Val Asp 275 280 285 Leu Ser Gly Leu Lys Glu Leu Ile Leu Leu Asn Leu Phe Ile Asn Asn 290 295 300 Leu His Gly Glu Ile Pro Gly Cys Ile Ala Glu Leu Pro Lys Leu Glu 305 310 315 320 Met Leu Asn Leu Trp Arg Asn Asn Phe Thr Gly Ser Ile Pro Ser Lys 325 330 335 Leu Gly Met Asn Gly Lys Leu Ile Glu Ile Asp Leu Ser Ser Asn Arg 340 345 350 Leu Thr Gly Leu Ile Pro Lys Ser Leu Cys Phe Gly Arg Asn Leu Lys 355 360 365 Ile Leu Ile Leu Leu Asp Asn Phe Leu Phe Gly Pro Leu Pro Asp Asp 370 375 380 Phe Gly Gln Cys Arg Thr Leu Ser Arg Val Arg Met Gly Gln Asn Tyr 385 390 395 400 Leu Ser Gly Ser Ile Pro Thr Gly Phe Leu Tyr Leu Pro Glu Leu Ser 405 410 415 Leu Val Glu Leu Gln Asn Asn Tyr Ile Ser Gly Gln Leu Trp Asn Glu 420 425 430 Lys Ser Ser Ala Ser Ser Lys Leu Glu Gly Leu Asn Leu Ser Asn Asn 435 440 445 Arg Leu Ser Gly Ala Leu Pro Ser Ala Ile Gly Asn Tyr Ser Gly Leu 450 455 460 Lys Asn Leu Val Leu Thr Gly Asn Gly Phe Ser Gly Asp Ile Pro Ser 465 470 475 480 Asp Ile Gly Arg Leu Lys Ser Ile Leu Lys Leu Asp Leu Ser Arg Asn 485 490 495 Asn Phe Ser Gly Thr Ile Pro Pro Gln Ile Gly Asn Cys Leu Ser Leu 500 505 510 Thr Tyr Leu Asp Leu Ser Gln Asn Gln Leu Ser Gly Pro Ile Pro Val 515 520 525 Gln Ile Ala Gln Ile His Ile Leu Asn Tyr Ile Asn Ile Ser Trp Asn 530 535 540 His Phe Asn Glu Ser Leu Pro Ala Glu Ile Gly Leu Met Lys Ser Leu 545 550 555 560 Thr Ser Ala Asp Phe Ser His Asn Asn Leu Ser Gly Ser Ile Pro Glu 565 570 575 Thr Gly Gln Tyr Leu Tyr Phe Asn Ser Thr Ser Phe Thr Gly Asn Pro 580 585 590 Tyr Leu Ser Gly Ser Asp Ser Thr Pro Ser Asn Ile Thr Ser Asn Ser 595 600 605 Pro Ser Glu Leu Gly Asp Gly Ser Asp Ser Arg Thr Lys Val Pro Thr 610 615 620 Ile Tyr Lys Phe Ile Phe Ala Phe Gly Leu Leu Phe Cys Ser Leu Ile 625 630 635 640 Phe Val Val Leu Ala Ile Ile Lys Thr Arg Lys Gly Ser Lys Asn Ser 645 650 655 Asn Leu Trp Lys Leu Thr Ala Phe Gln Lys Leu Glu Phe Gly Ser Glu 660 665 670 Asp Val Leu Gln Cys Leu Ile Asp Asn Asn Val Ile Gly Arg Gly Gly 675 680 685 Ala Gly Ile Val Tyr Lys Gly Thr Met Pro Asn Gly Asp His Val Ala 690 695 700 Val Lys Lys Leu Gly Ile Ser Lys Gly Ser His Asp Asn Gly Leu Ser 705 710 715 720 Ala Glu Leu Asn Thr Leu Gly Lys Ile Arg His Arg Tyr Ile Val Arg 725 730 735 Leu Leu Ala Phe Cys Ser Asn Lys Glu Val Asn Leu Leu Val Tyr Glu 740 745 750 Tyr Met Leu Asn Gly Ser Leu Gly Glu Val Leu His Gly Lys Asn Gly 755 760 765 Gly Gln Leu Gln Trp Glu Thr Arg Leu Lys Ile Ala Ile Glu Ala Ala 770 775 780 Lys Gly Leu Ser Tyr Leu His His Asp Cys Ser Pro Met Ile Ile His 785 790 795 800 Arg Asp Val Lys Ser Asn Asn Ile Leu Leu Asn Ser Glu Leu Glu Ala 805 810 815 His Val Ala Asp Phe Gly Leu Ala Lys Tyr Phe Arg Asn Asn Gly Thr 820 825 830 Ser Glu Cys Met Ser Ala Ile Ala Gly Ser Tyr Gly Tyr Ile Ala Pro 835 840 845 Glu Tyr Ala Tyr Thr Leu Lys Ile Asp Glu Lys Ser Asp Val Tyr Ser 850 855 860 Phe Gly Val Val Leu Leu Glu Leu Ile Thr Gly Arg Arg Pro Val Gly 865 870 875 880 Asn Phe Gly Glu Glu Gly Met Asp Ile Val Gln Trp Ala Lys Thr Glu 885 890 895 Thr Lys Trp Ser Lys Glu Gly Val Val Lys Ile Leu Asp Glu Arg Leu 900 905 910 Lys Asn Val Ala Ile Val Glu Ala Met Gln Val Phe Phe Val Ala Met 915 920 925 Leu Cys Val Glu Glu Tyr Ser Ile Glu Arg Pro Thr Met Arg Glu Val 930 935 940 Val Gln Met Leu Ser Gln Ala Lys Gln Pro Asn Thr Phe Gln Ile Gln 945 950 955 960 (2) INFORMATION FOR SEQ ID NO:19: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 3850 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 1..3850 (D) OTHER INFORMATION: /note= “TRK2 Xa21 gene from tomato” (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 2..3487 (D) OTHER INFORMATION: /product= “TRK2” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:19: T GAC TCT CTC TGT CTC TCT CTG TTC GCA GCC CCA AAA AGT AGG GTT 46 Asp Ser Leu Cys Leu Ser Leu Phe Ala Ala Pro Lys Ser Arg Val 1 5 10 15 AGG GCT AGG GTT TTT GAG TTT CAA AAC CCC ATT TCT GGT TCC TAT AAT 94 Arg Ala Arg Val Phe Glu Phe Gln Asn Pro Ile Ser Gly Ser Tyr Asn 20 25 30 CTT CAC ATA CAA GGG GAG TTT GTC TCT GTT GCA TTC TTT GAA GAC CCT 142 Leu His Ile Gln Gly Glu Phe Val Ser Val Ala Phe Phe Glu Asp Pro 35 40 45 TTT GGG GTT TTA CTA ATG GGT CGT TGT TGT TTT GTC ATC AAA TGG TAC 190 Phe Gly Val Leu Leu Met Gly Arg Cys Cys Phe Val Ile Lys Trp Tyr 50 55 60 TAT CAT GAC ATA CCC TTG AAA GTT TTT CTC ATC CTT TGT GTT TTC TTC 238 Tyr His Asp Ile Pro Leu Lys Val Phe Leu Ile Leu Cys Val Phe Phe 65 70 75 TTA GTT CAT GGC TAT GCA CTT TCC TCG GAT TCG GAT AAA TCA GCG CTC 286 Leu Val His Gly Tyr Ala Leu Ser Ser Asp Ser Asp Lys Ser Ala Leu 80 85 90 95 TTG GAG TTA AAG GCC TCA TTT TCA GAT TCC TCT GGA GTG ATT TCT AGC 334 Leu Glu Leu Lys Ala Ser Phe Ser Asp Ser Ser Gly Val Ile Ser Ser 100 105 110 TGG AGC TCC AGA AAT AAT GAT CAC TGT TCA TGG TTT GGT GTC TCC TGT 382 Trp Ser Ser Arg Asn Asn Asp His Cys Ser Trp Phe Gly Val Ser Cys 115 120 125 GAT TCC GAT TCA CGT GTT GTG GCT TTG AAC ATC ACT GGA GGT AAT TTG 430 Asp Ser Asp Ser Arg Val Val Ala Leu Asn Ile Thr Gly Gly Asn Leu 130 135 140 GGT TCT TTA TCT TGT GCT AAA ATT GCT CAA TTT CCT TTG TAT GGC TTT 478 Gly Ser Leu Ser Cys Ala Lys Ile Ala Gln Phe Pro Leu Tyr Gly Phe 145 150 155 GGA ATT ACA AGG GTT TGT GCT AAT AAT AGT GTC AAG CTT GTT GGT AAA 526 Gly Ile Thr Arg Val Cys Ala Asn Asn Ser Val Lys Leu Val Gly Lys 160 165 170 175 GTA CCT CTC GCA ATA TCA AAA TTA ACT GAA CTA AGG GTT TTA TCC TTG 574 Val Pro Leu Ala Ile Ser Lys Leu Thr Glu Leu Arg Val Leu Ser Leu 180 185 190 CCT TTT AAT GAA TTG CGT GGT GAT ATT CCA TTG GGA ATT TGG GAT ATG 622 Pro Phe Asn Glu Leu Arg Gly Asp Ile Pro Leu Gly Ile Trp Asp Met 195 200 205 GAC AAA CTT GAA GTT TTG GAT CTG CAA GGG AAT TTA ATT ACT GGG TCT 670 Asp Lys Leu Glu Val Leu Asp Leu Gln Gly Asn Leu Ile Thr Gly Ser 210 215 220 TTG CCA TTG GAG TTT AAG GGG TTG AGG AAA TTG AGG GTT TTA AAC TTG 718 Leu Pro Leu Glu Phe Lys Gly Leu Arg Lys Leu Arg Val Leu Asn Leu 225 230 235 GGT TTT AAT CAG ATT GTG GGT GCC ATA CCG AAT TCC TTG TCA AAT TGC 766 Gly Phe Asn Gln Ile Val Gly Ala Ile Pro Asn Ser Leu Ser Asn Cys 240 245 250 255 CTT GCT CTA CAA ATC TTT AAT CTT GCT GGA AAT AGG GTA AAT GGG ACC 814 Leu Ala Leu Gln Ile Phe Asn Leu Ala Gly Asn Arg Val Asn Gly Thr 260 265 270 ATT CCA GCA TTC ATT GGT GGA TTT GAA GAT CTG AGG GGA ATC TAC CTG 862 Ile Pro Ala Phe Ile Gly Gly Phe Glu Asp Leu Arg Gly Ile Tyr Leu 275 280 285 TCT TTT AAT GAG CTT AGC GGG TCT ATT CCT GGT GAA ATT GGG CGT TCT 910 Ser Phe Asn Glu Leu Ser Gly Ser Ile Pro Gly Glu Ile Gly Arg Ser 290 295 300 TGT GAG AAG CTT CAA AGT CTA GAG ATG GCA GGT AAT ATC TTA GGT GGT 958 Cys Glu Lys Leu Gln Ser Leu Glu Met Ala Gly Asn Ile Leu Gly Gly 305 310 315 GTT ATT CCA AAA AGT TTA GGG AAC TGC ACA CGG TTG CAG TCA CTT GTC 1006 Val Ile Pro Lys Ser Leu Gly Asn Cys Thr Arg Leu Gln Ser Leu Val 320 325 330 335 TTA TAT TCA AAT TTG TTG GAA GAG GCT ATT CCA GCT GAA TTT GGT CAA 1054 Leu Tyr Ser Asn Leu Leu Glu Glu Ala Ile Pro Ala Glu Phe Gly Gln 340 345 350 CTA ACT GAG CTC GAG ATT CTT GAT TTG TCT AGG AAC AGC CTA AGT GGT 1102 Leu Thr Glu Leu Glu Ile Leu Asp Leu Ser Arg Asn Ser Leu Ser Gly 355 360 365 CGA CTA CCA TCT GAG CTG GGA AAC TGC TCG AAA CTA TCC ATT CTT GTA 1150 Arg Leu Pro Ser Glu Leu Gly Asn Cys Ser Lys Leu Ser Ile Leu Val 370 375 380 CTG TCA AGT TTG TGG GAT CCC CTT CCA AAT GTG TCT GAT TCA GCT CAT 1198 Leu Ser Ser Leu Trp Asp Pro Leu Pro Asn Val Ser Asp Ser Ala His 385 390 395 ACT ACT GAT GAG TTT AAC TTT TTT GAA GGC ACA ATC CCA TCA GAG ATC 1246 Thr Thr Asp Glu Phe Asn Phe Phe Glu Gly Thr Ile Pro Ser Glu Ile 400 405 410 415 ACC AGG CTT CCT AGT TTG AGA ATG ATA TGG GCT CCC AGG TCA ACT CTT 1294 Thr Arg Leu Pro Ser Leu Arg Met Ile Trp Ala Pro Arg Ser Thr Leu 420 425 430 TCA GGA AAA TTT CCT GGC AGT TGG GGT GCT TGT GAC AAT TTG GAG ATC 1342 Ser Gly Lys Phe Pro Gly Ser Trp Gly Ala Cys Asp Asn Leu Glu Ile 435 440 445 GTG AAC TTG GCT CAA AAT TAT TAT ACT GGA GTG ATT CCT GAG GAA TTG 1390 Val Asn Leu Ala Gln Asn Tyr Tyr Thr Gly Val Ile Pro Glu Glu Leu 450 455 460 GGT AGC TGC CAG AAG TTG CAT TTT CTT GAC TTG AGC TCA AAT AGG CTG 1438 Gly Ser Cys Gln Lys Leu His Phe Leu Asp Leu Ser Ser Asn Arg Leu 465 470 475 ACT GGA CAG CTT GTT GAG AAA CTG CCA GTC CCT TGC ATG TTT GTG TTC 1486 Thr Gly Gln Leu Val Glu Lys Leu Pro Val Pro Cys Met Phe Val Phe 480 485 490 495 GAT GTG AGT GGG AAT TAT CTC TCT GGT TCA ATT CCC AGG TTT TCC AAT 1534 Asp Val Ser Gly Asn Tyr Leu Ser Gly Ser Ile Pro Arg Phe Ser Asn 500 505 510 TAC AGT TGT GCT CAT GTT GTT TCC AGC GGT GGA GAG CCA TTT GGG CCC 1582 Tyr Ser Cys Ala His Val Val Ser Ser Gly Gly Glu Pro Phe Gly Pro 515 520 525 TAT GAT ACA TCA TCT GCA TAT CTA GCA CAT TTC ACC AGT AGA AGT GTT 1630 Tyr Asp Thr Ser Ser Ala Tyr Leu Ala His Phe Thr Ser Arg Ser Val 530 535 540 CTA GAC ACT ACA TTA TTT GCA GGT GAT GGT AAC CAT GCA GTA TTT CAT 1678 Leu Asp Thr Thr Leu Phe Ala Gly Asp Gly Asn His Ala Val Phe His 545 550 555 AAT TTC GGT GTT AAC AAC TTC ACG GGA AAT TTA CCG CCT TCC ATG CTA 1726 Asn Phe Gly Val Asn Asn Phe Thr Gly Asn Leu Pro Pro Ser Met Leu 560 565 570 575 ATT GCA CCT GAA ATG TTA GGC AAA CAA ATT GTA TAC GCA TTT CTT GCT 1774 Ile Ala Pro Glu Met Leu Gly Lys Gln Ile Val Tyr Ala Phe Leu Ala 580 585 590 GGT AGT AAC AGG TTT ACT GGA CCT TTT GCT GGT AAC TTG TTC GAG AAA 1822 Gly Ser Asn Arg Phe Thr Gly Pro Phe Ala Gly Asn Leu Phe Glu Lys 595 600 605 TGT CAT GAA TTG AAT GGA ATG ATT GTT AAT GTA AGC AAT AAT GCG TTG 1870 Cys His Glu Leu Asn Gly Met Ile Val Asn Val Ser Asn Asn Ala Leu 610 615 620 TCA GGT CAA ATC CCA GAG GAT ATT GGT GCA ATT TGT GGG TCT CTT AGG 1918 Ser Gly Gln Ile Pro Glu Asp Ile Gly Ala Ile Cys Gly Ser Leu Arg 625 630 635 CTG TTG GAT GGA TCC AAA AAT CAG ATT GTT GGG ACA GTC CCT CCG AGT 1966 Leu Leu Asp Gly Ser Lys Asn Gln Ile Val Gly Thr Val Pro Pro Ser 640 645 650 655 TTA GGG AGT CTG GTT TCA TTA GTT GCT CTC AAT TTA AGT TGG AAC CAC 2014 Leu Gly Ser Leu Val Ser Leu Val Ala Leu Asn Leu Ser Trp Asn His 660 665 670 CTG CGA GGT CAG ATT CCT AGC AGA CTT GGC CAG ATA AAG GAT CTC AGT 2062 Leu Arg Gly Gln Ile Pro Ser Arg Leu Gly Gln Ile Lys Asp Leu Ser 675 680 685 TAC CTC TCT TTG GCT GGC AAT AAT CTG GTT GGC CCA ATC CCC TCA AGT 2110 Tyr Leu Ser Leu Ala Gly Asn Asn Leu Val Gly Pro Ile Pro Ser Ser 690 695 700 TTT GGC CAA TTG CAC TCT TTA GAA ACG CTT GAA CTT TCT TCG AAT TCT 2158 Phe Gly Gln Leu His Ser Leu Glu Thr Leu Glu Leu Ser Ser Asn Ser 705 710 715 TTG TCT GGT GAA ATT CCA AAT AAT CTG GTA AAT TTG AGG AAT TTG ACT 2206 Leu Ser Gly Glu Ile Pro Asn Asn Leu Val Asn Leu Arg Asn Leu Thr 720 725 730 735 TCC CTT CTT CTG AAC AAC AAC AAT TTA TCA GGG AAA ATA CCT TCA GGC 2254 Ser Leu Leu Leu Asn Asn Asn Asn Leu Ser Gly Lys Ile Pro Ser Gly 740 745 750 TTG GCC AAT GTG ACC ACA CTG GCA GCA TTT AAC GTT TCT TTC AAT AAT 2302 Leu Ala Asn Val Thr Thr Leu Ala Ala Phe Asn Val Ser Phe Asn Asn 755 760 765 CTG TCT GGG CCA CTG CCT CTT AAC AAA GAT TTG ATG AAG TGT AAT AGT 2350 Leu Ser Gly Pro Leu Pro Leu Asn Lys Asp Leu Met Lys Cys Asn Ser 770 775 780 GTT CAG GGA AAC CCC TTT CTG CAA TCG TGC CAT GTA TTT TCT CTA TCA 2398 Val Gln Gly Asn Pro Phe Leu Gln Ser Cys His Val Phe Ser Leu Ser 785 790 795 ACA CCT TCT ACA GAT CAG CAG GGA AGA ATA GGG GAC TCA CAA GAT TCT 2446 Thr Pro Ser Thr Asp Gln Gln Gly Arg Ile Gly Asp Ser Gln Asp Ser 800 805 810 815 GCT GCG TCT CCT TCA GGT TCA ACC CAG AAA GGA GGG AGC AGC GGT TTC 2494 Ala Ala Ser Pro Ser Gly Ser Thr Gln Lys Gly Gly Ser Ser Gly Phe 820 825 830 AAC TCC ATA GAG ATT GCA TCC ATA ACA TCT GCG GCA GCT ATT GTG TCA 2542 Asn Ser Ile Glu Ile Ala Ser Ile Thr Ser Ala Ala Ala Ile Val Ser 835 840 845 GTT CTT CTT GCT CTG ATA GTC CTG TTC TTT TAC ACC AGA AAA TGG AAT 2590 Val Leu Leu Ala Leu Ile Val Leu Phe Phe Tyr Thr Arg Lys Trp Asn 850 855 860 CCA AGA TCT AGA GTT GCT GGA TCT ACC AGG AAA GAA GTC ACA GTG TTT 2638 Pro Arg Ser Arg Val Ala Gly Ser Thr Arg Lys Glu Val Thr Val Phe 865 870 875 ACA GAA GTT CCG GTT CCT TTA ACA TTT GAA AAT GTA GTG CGG GCC ACA 2686 Thr Glu Val Pro Val Pro Leu Thr Phe Glu Asn Val Val Arg Ala Thr 880 885 890 895 GGG AGC TTC AAT GCA AGC AAT TGC ATA GGC AGT GGA GGT TTT GGA GCA 2734 Gly Ser Phe Asn Ala Ser Asn Cys Ile Gly Ser Gly Gly Phe Gly Ala 900 905 910 ACA TAC AAA GCG GAG ATT GCA CCA GGG TTC CTA GTG GCA GTA AAG CGA 2782 Thr Tyr Lys Ala Glu Ile Ala Pro Gly Phe Leu Val Ala Val Lys Arg 915 920 925 CTT GCT GTA GGA CGT TTT CAG GGG ATT CAA CAG TTT GAT GCA GAA ATC 2830 Leu Ala Val Gly Arg Phe Gln Gly Ile Gln Gln Phe Asp Ala Glu Ile 930 935 940 AGA ACT CTG GGG AGG CTT CGA CAT CCA AAC CTC GTA ACT CTG ATA GGA 2878 Arg Thr Leu Gly Arg Leu Arg His Pro Asn Leu Val Thr Leu Ile Gly 945 950 955 TAT CAT AAT AGT GAA ACA GAA ATG TTT CTG ATC TAT AAC TAT TTG CCA 2926 Tyr His Asn Ser Glu Thr Glu Met Phe Leu Ile Tyr Asn Tyr Leu Pro 960 965 970 975 GGT GGT AAT TTG GAA AAG TTT ATT CAG GAG AGG TCT ACA AGG GCT GTG 2974 Gly Gly Asn Leu Glu Lys Phe Ile Gln Glu Arg Ser Thr Arg Ala Val 980 985 990 GAC TGG AGG GTT CTT CAC AAG ATT GCT TTG GAT GTA GCC CGT GCA CTT 3022 Asp Trp Arg Val Leu His Lys Ile Ala Leu Asp Val Ala Arg Ala Leu 995 1000 1005 GCT TAC CTG CAT GAT CAG TGT GTA CCA CGT GTG CTT CAT CGT GAT GTG 3070 Ala Tyr Leu His Asp Gln Cys Val Pro Arg Val Leu His Arg Asp Val 1010 1015 1020 AAG CCG AGC AAC ATT TTA TTG GAT GAG GAG TAT AAT GCA TAT TTA TCT 3118 Lys Pro Ser Asn Ile Leu Leu Asp Glu Glu Tyr Asn Ala Tyr Leu Ser 1025 1030 1035 GAT TTT GGT TTG GCT AGA TTA CTG GGA ACT TCA GAG ACC CAT GCA ACT 3166 Asp Phe Gly Leu Ala Arg Leu Leu Gly Thr Ser Glu Thr His Ala Thr 1040 1045 1050 1055 ACT GGT GTG GCG GGA ACT TTT GGA TAT GTT GCT CCT GAA TAT GCC ATG 3214 Thr Gly Val Ala Gly Thr Phe Gly Tyr Val Ala Pro Glu Tyr Ala Met 1060 1065 1070 ACT TGC CGC GTC TCG GAC AAG GCT GAT GTC TAC AGT TAT GGG GTT GTG 3262 Thr Cys Arg Val Ser Asp Lys Ala Asp Val Tyr Ser Tyr Gly Val Val 1075 1080 1085 TTG CTT GAG TTA ATA TCA GAT AAG AAA GCA CTA GAT CCG TCT TTC TCT 3310 Leu Leu Glu Leu Ile Ser Asp Lys Lys Ala Leu Asp Pro Ser Phe Ser 1090 1095 1100 TCT TAT GGA AAT GGA TTC AAT ATT GTA GCT TGG GCA TGC ATG CTT TTA 3358 Ser Tyr Gly Asn Gly Phe Asn Ile Val Ala Trp Ala Cys Met Leu Leu 1105 1110 1115 CGC AGG GCC GTG CTA AGG AGT TCT TTA CGG CTG GTC TAT GGG ATT CAG 3406 Arg Arg Ala Val Leu Arg Ser Ser Leu Arg Leu Val Tyr Gly Ile Gln 1120 1125 1130 1135 GTC CAC ATG ATG ATT TGG ATG AGG TCC TAC ACT TGG CAG TGG TCT GCA 3454 Val His Met Met Ile Trp Met Arg Ser Tyr Thr Trp Gln Trp Ser Ala 1140 1145 1150 CGG TTG ACT CTC TTT CTA CTA GAC CAA CAA TGAAGCAAGT AGTAAGACGG 3504 Arg Leu Thr Leu Phe Leu Leu Asp Gln Gln 1155 1160 TTGAAGCAAC TTCAACCCCC GTCGTGTTAG CTGCGGCATG TGTTTTGGAT AGGATATGGT 3564 TTAGCCCAAT TGTAATNTTA AAACTTGCCC TTGATAGTAA GGTGTATTTG GGTGTCTCGT 3624 ATTAGGTTCA GATTTGTATT TGTAGCCTGC TTGTGAATTG TAGTATATAG CCAGCCCCCN 3684 ATTTTTCCNA TGTCATGTCC CNTAATTAGG GGGTGTGCAG ATTCTTCTNG CAGAAGAGTG 3744 CAGATACTTG TCTTCAACAT GTACCNACAT TTTTTTTTGT TTGTTAAATA AGAGCAAAAA 3804 ATAGGAACCA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA ANNNGC 3850 (2) INFORMATION FOR SEQ ID NO:20: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1161 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:20: Asp Ser Leu Cys Leu Ser Leu Phe Ala Ala Pro Lys Ser Arg Val Arg 1 5 10 15 Ala Arg Val Phe Glu Phe Gln Asn Pro Ile Ser Gly Ser Tyr Asn Leu 20 25 30 His Ile Gln Gly Glu Phe Val Ser Val Ala Phe Phe Glu Asp Pro Phe 35 40 45 Gly Val Leu Leu Met Gly Arg Cys Cys Phe Val Ile Lys Trp Tyr Tyr 50 55 60 His Asp Ile Pro Leu Lys Val Phe Leu Ile Leu Cys Val Phe Phe Leu 65 70 75 80 Val His Gly Tyr Ala Leu Ser Ser Asp Ser Asp Lys Ser Ala Leu Leu 85 90 95 Glu Leu Lys Ala Ser Phe Ser Asp Ser Ser Gly Val Ile Ser Ser Trp 100 105 110 Ser Ser Arg Asn Asn Asp His Cys Ser Trp Phe Gly Val Ser Cys Asp 115 120 125 Ser Asp Ser Arg Val Val Ala Leu Asn Ile Thr Gly Gly Asn Leu Gly 130 135 140 Ser Leu Ser Cys Ala Lys Ile Ala Gln Phe Pro Leu Tyr Gly Phe Gly 145 150 155 160 Ile Thr Arg Val Cys Ala Asn Asn Ser Val Lys Leu Val Gly Lys Val 165 170 175 Pro Leu Ala Ile Ser Lys Leu Thr Glu Leu Arg Val Leu Ser Leu Pro 180 185 190 Phe Asn Glu Leu Arg Gly Asp Ile Pro Leu Gly Ile Trp Asp Met Asp 195 200 205 Lys Leu Glu Val Leu Asp Leu Gln Gly Asn Leu Ile Thr Gly Ser Leu 210 215 220 Pro Leu Glu Phe Lys Gly Leu Arg Lys Leu Arg Val Leu Asn Leu Gly 225 230 235 240 Phe Asn Gln Ile Val Gly Ala Ile Pro Asn Ser Leu Ser Asn Cys Leu 245 250 255 Ala Leu Gln Ile Phe Asn Leu Ala Gly Asn Arg Val Asn Gly Thr Ile 260 265 270 Pro Ala Phe Ile Gly Gly Phe Glu Asp Leu Arg Gly Ile Tyr Leu Ser 275 280 285 Phe Asn Glu Leu Ser Gly Ser Ile Pro Gly Glu Ile Gly Arg Ser Cys 290 295 300 Glu Lys Leu Gln Ser Leu Glu Met Ala Gly Asn Ile Leu Gly Gly Val 305 310 315 320 Ile Pro Lys Ser Leu Gly Asn Cys Thr Arg Leu Gln Ser Leu Val Leu 325 330 335 Tyr Ser Asn Leu Leu Glu Glu Ala Ile Pro Ala Glu Phe Gly Gln Leu 340 345 350 Thr Glu Leu Glu Ile Leu Asp Leu Ser Arg Asn Ser Leu Ser Gly Arg 355 360 365 Leu Pro Ser Glu Leu Gly Asn Cys Ser Lys Leu Ser Ile Leu Val Leu 370 375 380 Ser Ser Leu Trp Asp Pro Leu Pro Asn Val Ser Asp Ser Ala His Thr 385 390 395 400 Thr Asp Glu Phe Asn Phe Phe Glu Gly Thr Ile Pro Ser Glu Ile Thr 405 410 415 Arg Leu Pro Ser Leu Arg Met Ile Trp Ala Pro Arg Ser Thr Leu Ser 420 425 430 Gly Lys Phe Pro Gly Ser Trp Gly Ala Cys Asp Asn Leu Glu Ile Val 435 440 445 Asn Leu Ala Gln Asn Tyr Tyr Thr Gly Val Ile Pro Glu Glu Leu Gly 450 455 460 Ser Cys Gln Lys Leu His Phe Leu Asp Leu Ser Ser Asn Arg Leu Thr 465 470 475 480 Gly Gln Leu Val Glu Lys Leu Pro Val Pro Cys Met Phe Val Phe Asp 485 490 495 Val Ser Gly Asn Tyr Leu Ser Gly Ser Ile Pro Arg Phe Ser Asn Tyr 500 505 510 Ser Cys Ala His Val Val Ser Ser Gly Gly Glu Pro Phe Gly Pro Tyr 515 520 525 Asp Thr Ser Ser Ala Tyr Leu Ala His Phe Thr Ser Arg Ser Val Leu 530 535 540 Asp Thr Thr Leu Phe Ala Gly Asp Gly Asn His Ala Val Phe His Asn 545 550 555 560 Phe Gly Val Asn Asn Phe Thr Gly Asn Leu Pro Pro Ser Met Leu Ile 565 570 575 Ala Pro Glu Met Leu Gly Lys Gln Ile Val Tyr Ala Phe Leu Ala Gly 580 585 590 Ser Asn Arg Phe Thr Gly Pro Phe Ala Gly Asn Leu Phe Glu Lys Cys 595 600 605 His Glu Leu Asn Gly Met Ile Val Asn Val Ser Asn Asn Ala Leu Ser 610 615 620 Gly Gln Ile Pro Glu Asp Ile Gly Ala Ile Cys Gly Ser Leu Arg Leu 625 630 635 640 Leu Asp Gly Ser Lys Asn Gln Ile Val Gly Thr Val Pro Pro Ser Leu 645 650 655 Gly Ser Leu Val Ser Leu Val Ala Leu Asn Leu Ser Trp Asn His Leu 660 665 670 Arg Gly Gln Ile Pro Ser Arg Leu Gly Gln Ile Lys Asp Leu Ser Tyr 675 680 685 Leu Ser Leu Ala Gly Asn Asn Leu Val Gly Pro Ile Pro Ser Ser Phe 690 695 700 Gly Gln Leu His Ser Leu Glu Thr Leu Glu Leu Ser Ser Asn Ser Leu 705 710 715 720 Ser Gly Glu Ile Pro Asn Asn Leu Val Asn Leu Arg Asn Leu Thr Ser 725 730 735 Leu Leu Leu Asn Asn Asn Asn Leu Ser Gly Lys Ile Pro Ser Gly Leu 740 745 750 Ala Asn Val Thr Thr Leu Ala Ala Phe Asn Val Ser Phe Asn Asn Leu 755 760 765 Ser Gly Pro Leu Pro Leu Asn Lys Asp Leu Met Lys Cys Asn Ser Val 770 775 780 Gln Gly Asn Pro Phe Leu Gln Ser Cys His Val Phe Ser Leu Ser Thr 785 790 795 800 Pro Ser Thr Asp Gln Gln Gly Arg Ile Gly Asp Ser Gln Asp Ser Ala 805 810 815 Ala Ser Pro Ser Gly Ser Thr Gln Lys Gly Gly Ser Ser Gly Phe Asn 820 825 830 Ser Ile Glu Ile Ala Ser Ile Thr Ser Ala Ala Ala Ile Val Ser Val 835 840 845 Leu Leu Ala Leu Ile Val Leu Phe Phe Tyr Thr Arg Lys Trp Asn Pro 850 855 860 Arg Ser Arg Val Ala Gly Ser Thr Arg Lys Glu Val Thr Val Phe Thr 865 870 875 880 Glu Val Pro Val Pro Leu Thr Phe Glu Asn Val Val Arg Ala Thr Gly 885 890 895 Ser Phe Asn Ala Ser Asn Cys Ile Gly Ser Gly Gly Phe Gly Ala Thr 900 905 910 Tyr Lys Ala Glu Ile Ala Pro Gly Phe Leu Val Ala Val Lys Arg Leu 915 920 925 Ala Val Gly Arg Phe Gln Gly Ile Gln Gln Phe Asp Ala Glu Ile Arg 930 935 940 Thr Leu Gly Arg Leu Arg His Pro Asn Leu Val Thr Leu Ile Gly Tyr 945 950 955 960 His Asn Ser Glu Thr Glu Met Phe Leu Ile Tyr Asn Tyr Leu Pro Gly 965 970 975 Gly Asn Leu Glu Lys Phe Ile Gln Glu Arg Ser Thr Arg Ala Val Asp 980 985 990 Trp Arg Val Leu His Lys Ile Ala Leu Asp Val Ala Arg Ala Leu Ala 995 1000 1005 Tyr Leu His Asp Gln Cys Val Pro Arg Val Leu His Arg Asp Val Lys 1010 1015 1020 Pro Ser Asn Ile Leu Leu Asp Glu Glu Tyr Asn Ala Tyr Leu Ser Asp 1025 1030 1035 1040 Phe Gly Leu Ala Arg Leu Leu Gly Thr Ser Glu Thr His Ala Thr Thr 1045 1050 1055 Gly Val Ala Gly Thr Phe Gly Tyr Val Ala Pro Glu Tyr Ala Met Thr 1060 1065 1070 Cys Arg Val Ser Asp Lys Ala Asp Val Tyr Ser Tyr Gly Val Val Leu 1075 1080 1085 Leu Glu Leu Ile Ser Asp Lys Lys Ala Leu Asp Pro Ser Phe Ser Ser 1090 1095 1100 Tyr Gly Asn Gly Phe Asn Ile Val Ala Trp Ala Cys Met Leu Leu Arg 1105 1110 1115 1120 Arg Ala Val Leu Arg Ser Ser Leu Arg Leu Val Tyr Gly Ile Gln Val 1125 1130 1135 His Met Met Ile Trp Met Arg Ser Tyr Thr Trp Gln Trp Ser Ala Arg 1140 1145 1150 Leu Thr Leu Phe Leu Leu Asp Gln Gln 1155 1160 (2) INFORMATION FOR SEQ ID NO:21: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 473 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 1..473 (D) OTHER INFORMATION: /note= “TRK3 Xa21 gene from tomato” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:21: TCAAGCAACA ATTTGTCAGG CCAGATTCCC AAGTCCTTGA GGAATCTTGA ACATCTCATG 60 TATTTCAATG TCTCGTTCAA TGGGCTCATG GGTGAAATTC CAGATGGAGG GCCATTCGTA 120 AATTTTACAG CTGAATCATT CATGGGTAAC CCTGCATTAT GTGGATCATC ACGCTTCCGT 180 GTGATGCAAT GCAGAGTCAC TAGTCTTGAA AGAAAAGGAA AGAGTAGAGT CTTAACTTCT 240 GTTCTTGCAT CAGCTTCCTC AGGAGTTGTA GTCACGACCA TTTTCATCAT TTGGTTTCTG 300 AAATGCCGAA AAAGGAGTAC GGAACTTCCT CTAGTTGATA CATTTGGTCA GGTACATAAG 360 AGGATTTCGT ACTATGATAT TCCTCAAGGG ACAAACAGCT TTGATGAAGC AAACTTGATT 420 GGAAGGGGGA GCCTTGGTTT GGTCTACAAA GGAAAGCTTG AAAATCCTAA GCG 473 (2) INFORMATION FOR SEQ ID NO:22: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 159 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (ix) FEATURE: (A) NAME/KEY: Protein (B) LOCATION: 1..159 (D) OTHER INFORMATION: /note= “TRK3 Xa21 gene from tomato amino acid sequence” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22: Ser Ser Asn Asn Leu Ser Gly Gln Ile Pro Lys Ser Leu Arg Asn Leu 1 5 10 15 Glu His Leu Met Tyr Phe Asn Val Ser Phe Asn Gly Leu Met Gly Glu 20 25 30 Ile Pro Asp Gly Gly Pro Phe Val Asn Phe Thr Ala Glu Ser Phe Met 35 40 45 Gly Asn Pro Ala Leu Cys Gly Ser Ser Arg Phe Arg Val Met Gln Cys 50 55 60 Arg Val Thr Ser Leu Glu Arg Lys Gly Lys Ser Arg Val Leu Thr Ser 65 70 75 80 Val Leu Ala Ser Ala Ser Ser Gly Val Val Val Thr Thr Ile Phe Ile 85 90 95 Ile Trp Phe Leu Lys Cys Arg Lys Arg Ser Thr Glu Leu Pro Leu Val 100 105 110 Asp Thr Phe Gly Gln Val His Lys Arg Ile Ser Tyr Tyr Asp Ile Pro 115 120 125 Gln Gly Thr Asn Ser Phe Asp Glu Ala Asn Leu Ile Gly Arg Gly Ser 130 135 140 Leu Leu Gly Leu Val Tyr Lys Gly Lys Leu Glu Asn Pro Lys Arg 145 150 155 (2) INFORMATION FOR SEQ ID NO:23: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 1438 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (ix) FEATURE: (A) NAME/KEY: CDS (B) LOCATION: 2..1438 (D) OTHER INFORMATION: /note= “TRK4 Xa21 gene from tomato” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:23: A GCT TGG ATC AAT TTA ACA ATG ATA AAC TGC AAT TTA GCT GGT CCT 46 Ala Trp Ile Asn Leu Thr Met Ile Asn Cys Asn Leu Ala Gly Pro 1 5 10 15 TTG CCT GAA TTT CTT GGA ACT ATG TCT TCT TTA GAG GTT TTG TTG TTG 94 Leu Pro Glu Phe Leu Gly Thr Met Ser Ser Leu Glu Val Leu Leu Leu 20 25 30 TCT ACA AAT AGG CTT TCA GGG CCT ATT CCA GGT ACT TTC AAG GAT GCA 142 Ser Thr Asn Arg Leu Ser Gly Pro Ile Pro Gly Thr Phe Lys Asp Ala 35 40 45 GTG CTG AAG ATG CTT TGG TTG AAC GAT CAG TCG GGT GAT GGT ATG AGT 190 Val Leu Lys Met Leu Trp Leu Asn Asp Gln Ser Gly Asp Gly Met Ser 50 55 60 GGT TCA ATA GAT GTT GTT GCA ACT ATG GTA TCA CTT ACA CAT CTT TGG 238 Gly Ser Ile Asp Val Val Ala Thr Met Val Ser Leu Thr His Leu Trp 65 70 75 CTT CAT GGG AAT CAA TTT TCA GGT AAA ATC CCA GTA GAG ATT GGT AAT 286 Leu His Gly Asn Gln Phe Ser Gly Lys Ile Pro Val Glu Ile Gly Asn 80 85 90 95 CTA ACA AAT CTG AAG GAT CTC AGT GTG AAT ACA AAT AAC CTT GTT GGA 334 Leu Thr Asn Leu Lys Asp Leu Ser Val Asn Thr Asn Asn Leu Val Gly 100 105 110 TTA ATC CCT GAA AGT TTA GCT AAT ATG CCA TTA GAC AAT CTT GAT TTG 382 Leu Ile Pro Glu Ser Leu Ala Asn Met Pro Leu Asp Asn Leu Asp Leu 115 120 125 AAT AAT AAT CAT TTT ATG GGA CCA GTT CCT AAG TTC AAG GCT ACT AAT 430 Asn Asn Asn His Phe Met Gly Pro Val Pro Lys Phe Lys Ala Thr Asn 130 135 140 GTT AGT TTT ATG TCC AAC TCT TTT TGT CAA ACC AAA CAA GGA GCA GTA 478 Val Ser Phe Met Ser Asn Ser Phe Cys Gln Thr Lys Gln Gly Ala Val 145 150 155 TGT GCC CCT GAG GTT ATG GCA CTT TTA GAG TTT CTT GAT GGG GTG AAT 526 Cys Ala Pro Glu Val Met Ala Leu Leu Glu Phe Leu Asp Gly Val Asn 160 165 170 175 TAT CCT TCT AGG CTT GTT GAA TCA TGG TCT GGA AAC AAC CCT TGT GAC 574 Tyr Pro Ser Arg Leu Val Glu Ser Trp Ser Gly Asn Asn Pro Cys Asp 180 185 190 GGA CGT TGG TGG GGA ATA AGC TGT GAC GAT AAC CAA AAA GTT AGT GTT 622 Gly Arg Trp Trp Gly Ile Ser Cys Asp Asp Asn Gln Lys Val Ser Val 195 200 205 ATA AAC TTG CCC AAG TCT AAT CTT TCC GGG ACC TTG AGT CCT TCA ATC 670 Ile Asn Leu Pro Lys Ser Asn Leu Ser Gly Thr Leu Ser Pro Ser Ile 210 215 220 GCG AAC CTT GAA ACC GTT ACT CAC ATT TAT CTT GAA TCA AAT AAT CTT 718 Ala Asn Leu Glu Thr Val Thr His Ile Tyr Leu Glu Ser Asn Asn Leu 225 230 235 TCT GGT TTT GTT CCA TCT AGT TGG ACT AGT TTG AAA TCT CTG TCT ATT 766 Ser Gly Phe Val Pro Ser Ser Trp Thr Ser Leu Lys Ser Leu Ser Ile 240 245 250 255 CTT GAT TTG AGT AAT AAC AAT ATT TCC CCA CCT TTG CCT AAA TTT ACC 814 Leu Asp Leu Ser Asn Asn Asn Ile Ser Pro Pro Leu Pro Lys Phe Thr 260 265 270 ACC CCT TTG AAA CTT GTT CTA AAT GGA AAT CCA AAG CTG ACT TCT AAT 862 Thr Pro Leu Lys Leu Val Leu Asn Gly Asn Pro Lys Leu Thr Ser Asn 275 280 285 CCT CCT GGA GCA AAT CCT TCA CCA AAC AAC AGC ACA ACT CCT GCA GAT 910 Pro Pro Gly Ala Asn Pro Ser Pro Asn Asn Ser Thr Thr Pro Ala Asp 290 295 300 TCA CCC ACG TCG TCT GTA CCA TCT TCA CGA CCC AAC AGT TCA AGC TCT 958 Ser Pro Thr Ser Ser Val Pro Ser Ser Arg Pro Asn Ser Ser Ser Ser 305 310 315 GTG ATC TTT AAA CCC AGT GAA CAG TCA CCC GAG AAA AAG GAC TCA AAG 1006 Val Ile Phe Lys Pro Ser Glu Gln Ser Pro Glu Lys Lys Asp Ser Lys 320 325 330 335 TCA AAG ATA GCT ATA GTT GTG GTT CCT ATT GCT GGT TTT CTA CTT TTG 1054 Ser Lys Ile Ala Ile Val Val Val Pro Ile Ala Gly Phe Leu Leu Leu 340 345 350 GTT TGT CTT GCT ATT CCA CTG TAC ATT TAT GTC TGT AAG AAG AGT AAA 1102 Val Cys Leu Ala Ile Pro Leu Tyr Ile Tyr Val Cys Lys Lys Ser Lys 355 360 365 GAT AAG CAT CAA GCT CCA ACT GCT CTT GTG GTT CAT CCT AGA GAT CCG 1150 Asp Lys His Gln Ala Pro Thr Ala Leu Val Val His Pro Arg Asp Pro 370 375 380 TCT GAT TCG GAT AAT GTA GTC AAG ATT GCG ATT GCC AAT CAG ACT AAT 1198 Ser Asp Ser Asp Asn Val Val Lys Ile Ala Ile Ala Asn Gln Thr Asn 385 390 395 GGA AGT CTT TCC ACA GTA AAT GCA AGT GGT TCT GCT AGC ATA CAC AGT 1246 Gly Ser Leu Ser Thr Val Asn Ala Ser Gly Ser Ala Ser Ile His Ser 400 405 410 415 GGT GAA TCC CAT TTG ATC GAA GCT GGG AAT TTG CTC ATA TCG GTT CAA 1294 Gly Glu Ser His Leu Ile Glu Ala Gly Asn Leu Leu Ile Ser Val Gln 420 425 430 GTA CTT CGG AAT GTG ACT AAG AAT TTT TCT CCG GAA AAT GAA CTT GGA 1342 Val Leu Arg Asn Val Thr Lys Asn Phe Ser Pro Glu Asn Glu Leu Gly 435 440 445 CGT GGT GGT TTT GGT GTG GTT TAT AAG GGA GAA TTA GAT GAT GGG ACA 1390 Arg Gly Gly Phe Gly Val Val Tyr Lys Gly Glu Leu Asp Asp Gly Thr 450 455 460 CGA ATC GCT GTC AAA AGA ATG GAG GCT GGT ATT GTT AGC AAC AAA GCT 1438 Arg Ile Ala Val Lys Arg Met Glu Ala Gly Ile Val Ser Asn Lys Ala 465 470 475 (2) INFORMATION FOR SEQ ID NO:24: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 479 amino acids (B) TYPE: amino acid (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO:24: Ala Trp Ile Asn Leu Thr Met Ile Asn Cys Asn Leu Ala Gly Pro Leu 1 5 10 15 Pro Glu Phe Leu Gly Thr Met Ser Ser Leu Glu Val Leu Leu Leu Ser 20 25 30 Thr Asn Arg Leu Ser Gly Pro Ile Pro Gly Thr Phe Lys Asp Ala Val 35 40 45 Leu Lys Met Leu Trp Leu Asn Asp Gln Ser Gly Asp Gly Met Ser Gly 50 55 60 Ser Ile Asp Val Val Ala Thr Met Val Ser Leu Thr His Leu Trp Leu 65 70 75 80 His Gly Asn Gln Phe Ser Gly Lys Ile Pro Val Glu Ile Gly Asn Leu 85 90 95 Thr Asn Leu Lys Asp Leu Ser Val Asn Thr Asn Asn Leu Val Gly Leu 100 105 110 Ile Pro Glu Ser Leu Ala Asn Met Pro Leu Asp Asn Leu Asp Leu Asn 115 120 125 Asn Asn His Phe Met Gly Pro Val Pro Lys Phe Lys Ala Thr Asn Val 130 135 140 Ser Phe Met Ser Asn Ser Phe Cys Gln Thr Lys Gln Gly Ala Val Cys 145 150 155 160 Ala Pro Glu Val Met Ala Leu Leu Glu Phe Leu Asp Gly Val Asn Tyr 165 170 175 Pro Ser Arg Leu Val Glu Ser Trp Ser Gly Asn Asn Pro Cys Asp Gly 180 185 190 Arg Trp Trp Gly Ile Ser Cys Asp Asp Asn Gln Lys Val Ser Val Ile 195 200 205 Asn Leu Pro Lys Ser Asn Leu Ser Gly Thr Leu Ser Pro Ser Ile Ala 210 215 220 Asn Leu Glu Thr Val Thr His Ile Tyr Leu Glu Ser Asn Asn Leu Ser 225 230 235 240 Gly Phe Val Pro Ser Ser Trp Thr Ser Leu Lys Ser Leu Ser Ile Leu 245 250 255 Asp Leu Ser Asn Asn Asn Ile Ser Pro Pro Leu Pro Lys Phe Thr Thr 260 265 270 Pro Leu Lys Leu Val Leu Asn Gly Asn Pro Lys Leu Thr Ser Asn Pro 275 280 285 Pro Gly Ala Asn Pro Ser Pro Asn Asn Ser Thr Thr Pro Ala Asp Ser 290 295 300 Pro Thr Ser Ser Val Pro Ser Ser Arg Pro Asn Ser Ser Ser Ser Val 305 310 315 320 Ile Phe Lys Pro Ser Glu Gln Ser Pro Glu Lys Lys Asp Ser Lys Ser 325 330 335 Lys Ile Ala Ile Val Val Val Pro Ile Ala Gly Phe Leu Leu Leu Val 340 345 350 Cys Leu Ala Ile Pro Leu Tyr Ile Tyr Val Cys Lys Lys Ser Lys Asp 355 360 365 Lys His Gln Ala Pro Thr Ala Leu Val Val His Pro Arg Asp Pro Ser 370 375 380 Asp Ser Asp Asn Val Val Lys Ile Ala Ile Ala Asn Gln Thr Asn Gly 385 390 395 400 Ser Leu Ser Thr Val Asn Ala Ser Gly Ser Ala Ser Ile His Ser Gly 405 410 415 Glu Ser His Leu Ile Glu Ala Gly Asn Leu Leu Ile Ser Val Gln Val 420 425 430 Leu Arg Asn Val Thr Lys Asn Phe Ser Pro Glu Asn Glu Leu Gly Arg 435 440 445 Gly Gly Phe Gly Val Val Tyr Lys Gly Glu Leu Asp Asp Gly Thr Arg 450 455 460 Ile Ala Val Lys Arg Met Glu Ala Gly Ile Val Ser Asn Lys Ala 465 470 475 (2) INFORMATION FOR SEQ ID NO:25: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 686 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 1..686 (D) OTHER INFORMATION: /note= “TRK5 3′ from tomato” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:25: TGAGTCAGCA TTTGTGTTGA ATGGCAAGAA TTAGGCTAAC AAACCTCTTA ACTTGGAAGG 60 CAAAGGGTAA CGATAGCATT GGATGTGGCA AGAGGGGTTG AATACCTTTC ATAGCTTGGC 120 ACAACAAAGT TTCATTCATA GAGATTTAAA ACCGTCAAAC ATCCTTCTCG GGAGACGACA 180 TGAGAGCCAA GGTTGCAGAT TTTGGTTTGG TTAAGAAATG CCCCTGATGG AAAGTATTCT 240 GTGGAGACAC GTTTGGCTGG AACTTTTGGC TATCTTGCAC CTGAATACGC GGGTAAGCAT 300 TTCCACTCCT TGTATCATTA CATCTTTTTT AACCGAGAAC TGATTTGTAT GCCCCTAGCT 360 GTAAACTTTA GATCTTAGTA AATTTTAAAA TTATTCGATC ATCTGCATTG CTAGGCATTC 420 TGGTCTTCAT TACATTTAGA GACATTTGGC ACATAGTGTT AATACTGAGG CAATCTCCAT 480 GCGTAAATGC TGCTTTGTCA TTTTTATCGA ACTCATGAAC TATATGCTAC TATTATAAAA 540 GATAAGTTTC CATTTCGTGT GGATCAGCAT CTGAATTATT ATCCTATTAC ATCTCCTCTT 600 TGTTACAGCT ACTGGACGAG TCACAACCAA AGTAGACGTT TACCTTTGGC GTTGTTTTGA 660 TGGAGATCAT TACTGGTAGA AAAGCT 686 (2) INFORMATION FOR SEQ ID NO:26: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 407 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 1..407 (D) OTHER INFORMATION: /note= “TRK5 5′ from tomato” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:26: CTTTCTCCAA CTCCTTCTGG TTGGTAAGTT CTAAGGCTTT CTGTTCTTGG ACTAATGTAT 60 TTGTGACAAG TCTTCATCTA CAGTAACTTC AATTAATCTT GATTCTCAAT CTGTTTCTGG 120 TTCTTTACCT TCTGANATTA GTCAACTTTC TAATCTTAAA ACCCTTTCAC TTCAAAAAAA 180 CAAACTTTCT GGCCCTTTAC CTTCTTTTGC CAACATGTCA AAATTAGCTG ATCTTTTCTT 240 GGACAATAAC CAATTCACTT CTGTTCCTCA AGATTTCCTT TTGGGGGTTC CTAGTTTAGT 300 AACTTTAAGC ATTANTGAAA ATGCGGGACT CTCTCCTTGG CAAATACCTA TGTATTTAAC 360 TGANAGTACC AAATTTGGGA TCTCTATATG CTAGTAATGC AAGTATT 407 (2) INFORMATION FOR SEQ ID NO:27: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 131 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: (D) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (ix) FEATURE: (A) NAME/KEY: Protein (B) LOCATION: 1..131 (D) OTHER INFORMATION: /note= “TRK5 5′ amino acid sequence” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:27: Leu Ser Pro Thr Pro Ser Gly Trp Ser Thr Ser Lys Pro Phe Cys Ser 1 5 10 15 Trp Thr Asn Val Ile Cys Asp Lys Ser Ser Ser Thr Val Thr Ser Ile 20 25 30 Asn Leu Asp Ser Gln Ser Val Ser Gly Ser Leu Pro Ser Asp Ile Ser 35 40 45 Gln Leu Ser Asn Leu Lys Thr Leu Ser Leu Gln Lys Asn Lys Leu Ser 50 55 60 Gly Pro Leu Pro Ser Phe Ala Asn Met Ser Lys Leu Ala Asp Leu Phe 65 70 75 80 Leu Asp Asn Asn Gln Phe Thr Ser Val Pro Gln Asp Phe Leu Leu Gly 85 90 95 Val Pro Ser Leu Val Thr Leu Ser Ile Ser Glu Asn Ala Gly Leu Ser 100 105 110 Pro Trp Gln Ile Pro Met Tyr Leu Thr Glu Ser Thr Lys Phe Gly Ile 115 120 125 Ser Ile Cys 130 (2) INFORMATION FOR SEQ ID NO:28: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 865 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 1..865 (D) OTHER INFORMATION: /note= “TRK6 3′ from tomato” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:28: GCTTATGACA GTCATTGATC CAACTCTAGA CGTGAAAGAT GAGATAACCG AGAGCATTTC 60 CACCTTAGCT GAACTTGCTG GTCATTGCAC TGCAAGAGAA CCTGGTCAAC GGCCAGATAT 120 GGGCCACGCT GTAAACGTGC TGTCCCCACT TGTTGAGAAA TGGAAGCCTC TTGAGGATGA 180 TCCAGCAGGA CTATTGTGGT ATCGACTACA GTCTTCCCCT CAATCAAATG GTCAAGGGTT 240 GGCAAGAATC GGAAGGAAAA GACTTAAGTT ACGTGGATCT CGAGGACAGT AAGGGCAGTA 300 TCCCAGCAAG ACCAACTGGA TTTGCAGATT CATTTACATC AGCTGATGGT AGATAATGGA 360 GGTACTTCTA TGTAGTAGAT GTAGATATCA ATTTTCTTTG TATTGTATTG AGATTTTGAT 420 CGTATTTTCC ACGTGCCTTC GCTCATTTCT CCCCCTTCAA TGTGAATGTA TTAGAAATTT 480 AAACTATGTG TAGCCTCAGT TCCTTCTGTA GATATAAAAT AGCGGTGAAG GAGAACTATA 540 CATCGATCAG TTGAACTCCT CGCTCAGTCA CTATTTTCAT CTTCTACTAT GGTGAGATTT 600 AAGAGCATTT TTTTCACCTT TGCCTATTTT CGTCGTTTAG TTGTGCTGCT TCTGAAGCTC 660 TGTGCTGAAT ACATACTGAG CGGTGAAGTA GCCCGGTATA TAGAATATGT CGTTTGATTC 720 GAAGAATCTA ACCATATAGC TTCTTCCTTC TGCTCAAATA GGGCAATACT TGGAGAAGAT 780 AACCCTTATG TGTCCTCATC ATTTGTTGTT TTGAGAAAAA AGTATGATAT ATGTTGCCTT 840 AGACTCTTCG AAAAGGTATT GTCAT 865 (2) INFORMATION FOR SEQ ID NO:29: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 769 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 1..769 (D) OTHER INFORMATION: /note= “TRK7 3′ from tomato” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:29: AAGCTTTCGA TTCTCCCTAT ATGTCTCTCA TGTTAACTAA TATAGCTTGA TAAACCTAGT 60 AAATTCTTCA TACTTTGTGT ATATAGTGAT ATCGAAACGT GAGATGCAGC CTTTATCCGC 120 CTTGTTCTTT TTTCTTGGCA CTCTACTTGT TCTGTTACTT CTCATATTTA TCTTATGCAA 180 GTTTTTCAAA CCAGGAAAAC TGACAGCTTT GATTACTAGC ACATTTAAGC CTCTTCCAGG 240 TTTTGTTTTG TTTCGAATTC ATGTTACTTT GAGTATCTTA TTCGTTATTT TAAAATATGT 300 CTTTTTTCGG ATGATACAGA GATGAGTAAT GCTGTTAGTG TACATCTTCA TACAATAAGC 360 TACTTTAACT TTCATACATT GGAGAAAGCT ACGAAGAATT TTCACTCGGA TAACCTCCTT 420 GGATGTGGTG GATTTGGTCC GGTTTTCCTG GTAAGGTCAA TGTGTCTTAA CGAGTTGTAA 480 AATCCGTTTT TATAATTAGA TGCAGAGGTT AAGAATTGGC CCTAGTGTTT TTTCTTAGGG 540 GAAGTTAGGA GATGGACAAT TAGTTGCTGT CAAGAAGTTG TCTGTTGACA AATCGCAGCA 600 AGGGGACCGG GAGTTTCTTG CTGAGGTACG GATGATAACA AGTATACAAC ACAAGAACCT 660 TGTCCGCCTT CTTGGTTGTT TGTTCAAAAG GGGGATCAGA GGCCTTCTCG TGTAACGAAT 720 AACATGAAGA ATAAGGAGGC TTGGGACCAA ATACTATATT GGTATTTAT 769 (2) INFORMATION FOR SEQ ID NO:30: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 1..29 (D) OTHER INFORMATION: /note= “L3a LRR region primer” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:30: TCAAGCAACA ATTTGTCAGG NCARATHCC 29 (2) INFORMATION FOR SEQ ID NO:31: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 4 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:31: Gly Gln Ile Pro 1 (2) INFORMATION FOR SEQ ID NO:32: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 1..33 (D) OTHER INFORMATION: /note= “K2a kinase region primer” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:32: TAACAGCACA TTGCTTGATT TNANRTCNCG RTG 33 (2) INFORMATION FOR SEQ ID NO:33: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:33: His Cys Asp Ile Lys 1 5 (2) INFORMATION FOR SEQ ID NO:34: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:34: CGGTGCCCAT CGTCCACCAT GACAGCTTGA ATCTTATAAC 40 (2) INFORMATION FOR SEQ ID NO:35: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:35: CGGTGCCCAT CGTCCACCAC GACGGCGGCG GCGAACGCCG 40 (2) INFORMATION FOR SEQ ID NO:36: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 40 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:36: CAGCTGCCAT TTTCCACAAA GACAGCTTGA ATCTTATAAC 40 (2) INFORMATION FOR SEQ ID NO:37: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 1..33 (D) OTHER INFORMATION: /note= “K1a kinase region primer” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:37: CGCCTTAGGA TTTTCAAGCT TTCCYTTRTA NAC 33 (2) INFORMATION FOR SEQ ID NO:38: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (genomic) (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 1..33 (D) OTHER INFORMATION: /note= “K2b kinase region primer” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:38: TAACAGCACA TTGCTTGATT TNANRTCRCA RTG 33 (2) INFORMATION FOR SEQ ID NO:39: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 33 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 1..33 (D) OTHER INFORMATION: /note= “K2c kinase region primer” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:39: TAACAGCACA TTGCTTGATT TNANRTCYCT RTG 33 (2) INFORMATION FOR SEQ ID NO:40: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 1..18 (D) OTHER INFORMATION: /note= “L3u primer” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:40: TCAAGCAACA ATTTGTCA 18 (2) INFORMATION FOR SEQ ID NO:41: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 21 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 1..21 (D) OTHER INFORMATION: /note= “K1u primer” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:41: CGCCTTAGGA TTTTCAAGCT T 21 (2) INFORMATION FOR SEQ ID NO:42: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 18 base pairs (B) TYPE: nucleic acid (C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: DNA (ix) FEATURE: (A) NAME/KEY: - (B) LOCATION: 1..18 (D) OTHER INFORMATION: /note= “K2u primer” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:42: TAACAGCACA TTGCTTGA 18 (2) INFORMATION FOR SEQ ID NO:43: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 41 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:43: Ser Asn Cys Gly Ser Thr Tyr Cys Met Leu Gly Asn Thr Pro Phe Val 1 5 10 15 Ser Phe Ala Lys Val Lys Ser Gln Ile Asn Leu Ser Glu Val Val Ala 20 25 30 Lys Leu Ile Cys Asn Tyr Val Arg Ser 35 40 (2) INFORMATION FOR SEQ ID NO:44: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 29 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:44: Ser Gly Arg Ser Ser Lys Tyr Leu Leu His Leu Leu Leu Thr Phe Asp 1 5 10 15 Ile Phe Gln Ser Ile Cys Asn Phe Lys Ser Leu Val Ile 20 25 (2) INFORMATION FOR SEQ ID NO:45: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 17 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:45: Gly Met Ile Ser Asn Tyr Ile Leu Ser Thr Trp Asn Ser Val Leu Asp 1 5 10 15 Val (2) INFORMATION FOR SEQ ID NO:46: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 42 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (ix) FEATURE: (A) NAME/KEY: Modified-site (B) LOCATION: 14 (D) OTHER INFORMATION: /product= “OTHER” /note= “Xaa = His or Arg” (ix) FEATURE: (A) NAME/KEY: Modified-site (B) LOCATION: 15 (D) OTHER INFORMATION: /product= “OTHER” /note= “Xaa = Ile, Arg or Met” (ix) FEATURE: (A) NAME/KEY: Modified-site (B) LOCATION: 16 (D) OTHER INFORMATION: /product= “OTHER” /note= “Xaa = Gln, Pro, Lys or Thr” (ix) FEATURE: (A) NAME/KEY: Modified-site (B) LOCATION: 20 (D) OTHER INFORMATION: /product= “OTHER” /note= “Xaa = Pro or Leu” (ix) FEATURE: (A) NAME/KEY: Modified-site (B) LOCATION: 21 (D) OTHER INFORMATION: /product= “OTHER” /note= “Xaa = Phe, Leu or Ile” (ix) FEATURE: (A) NAME/KEY: Modified-site (B) LOCATION: 22 (D) OTHER INFORMATION: /product= “OTHER” /note= “Xaa = Gln or Leu” (ix) FEATURE: (A) NAME/KEY: Modified-site (B) LOCATION: 23 (D) OTHER INFORMATION: /product= “OTHER” /note= “Xaa = Lys or Thr” (ix) FEATURE: (A) NAME/KEY: Modified-site (B) LOCATION: 24 (D) OTHER INFORMATION: /product= “OTHER” /note= “Xaa = Ser, Thr, Ala, Asp or Glu” (ix) FEATURE: (A) NAME/KEY: Modified-site (B) LOCATION: 25 (D) OTHER INFORMATION: /product= “OTHER” /note= “Xaa = Ser or Thr” (ix) FEATURE: (A) NAME/KEY: Modified-site (B) LOCATION: 27 (D) OTHER INFORMATION: /product= “OTHER” /note= “Xaa = Pro, Arg, Ser or Thr” (ix) FEATURE: (A) NAME/KEY: Modified-site (B) LOCATION: 29 (D) OTHER INFORMATION: /product= “OTHER” /note= “Xaa = Phe, Ser, Leu, Ile, Thr or Met” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:46: Tyr Pro Arg Asp Val Trp Arg Ile Ser Lys Glu Ser Arg Xaa Xaa Xaa 1 5 10 15 Leu Ile Pro Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Arg Xaa Pro Pro Ile 20 25 30 Leu Thr Asp Ser Arg Ser Arg Arg His Gln 35 40 (2) INFORMATION FOR SEQ ID NO:47: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 15 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:47: Ser Asn Phe Asn Pro Arg Arg Val Ser Cys Gly Met Cys Phe Gly 1 5 10 15 (2) INFORMATION FOR SEQ ID NO:48: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 9 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (ix) FEATURE: (A) NAME/KEY: Modified-site (B) LOCATION: 5 (D) OTHER INFORMATION: /product= “OTHER” /note= “Xaa = Phe, Leu, Ile or Val” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:48: Pro Asn Cys Asn Xaa Lys Thr Cys Pro 1 5 (2) INFORMATION FOR SEQ ID NO:49: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:49: Gly Val Phe Gly Cys Leu Val Leu Gly Ser Asp Leu Tyr Leu 1 5 10 (2) INFORMATION FOR SEQ ID NO:50: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 5 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (xi) SEQUENCE DESCRIPTION: SEQ ID NO:50: Pro Ala Cys Glu Leu 1 5 (2) INFORMATION FOR SEQ ID NO:51: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 13 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (ix) FEATURE: (A) NAME/KEY: Modified-site (B) LOCATION: 6 (D) OTHER INFORMATION: /product= “OTHER” /note= “Xaa = Arg, Gln, Pro or Leu” (ix) FEATURE: (A) NAME/KEY: Modified-site (B) LOCATION: 9 (D) OTHER INFORMATION: /product= “OTHER” /note= “Xaa = Arg, Gln, Pro or Leu” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:51: Tyr Ile Ala Ser Pro Xaa Phe Phe Xaa Cys His Val Pro 1 5 10 (2) INFORMATION FOR SEQ ID NO:52: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 32 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (ix) FEATURE: (A) NAME/KEY: Modified-site (B) LOCATION: 21 (D) OTHER INFORMATION: /product= “OTHER” /note= “Xaa = Tyr, His, Asn or Asp” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:52: Leu Gly Gly Val Gln Ile Leu Leu Ala Glu Glu Cys Arg Tyr Leu Ser 1 5 10 15 Ser Thr Cys Thr Xaa Ile Phe Phe Cys Leu Leu Asn Lys Ser Lys Lys 20 25 30 (2) INFORMATION FOR SEQ ID NO:53: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 14 amino acids (B) TYPE: amino acid (C) STRANDEDNESS: (D) TOPOLOGY: linear (ii) MOLECULE TYPE: peptide (ix) FEATURE: (A) NAME/KEY: Modified-site (B) LOCATION: 13 (D) OTHER INFORMATION: /product= “OTHER” /note= “Xaa = Ile, Met, Thr, Asn, Lys, Ser or Arg” (ix) FEATURE: (A) NAME/KEY: Modified-site (B) LOCATION: 14 (D) OTHER INFORMATION: /product= “OTHER” /note= “Xaa = Cys, Arg, Ser or Gly” (xi) SEQUENCE DESCRIPTION: SEQ ID NO:53: Glu Pro Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Xaa Xaa 1 5 10 

What is claimed is:
 1. An isolated nucleic acid construct comprising an RRK polynucleotide sequence, which polynucleotide hybridizes to SEQ ID NOs: 1, 4, 6, 8, 10, or 11 under stringent conditions.
 2. The nucleic acid construct of claim 1, wherein the RRK polynucleotide sequence encodes an RRK polypeptide having an leucine rich repeat motif.
 3. The nucleic acid construct of claim 1, wherein the RRK polynucleotide sequence encodes an RRK polypeptide having a cytoplasmic protein kinase domain.
 4. The nucleic acid construct of claim 1, wherein the polynucleotide sequence is a full length gene.
 5. The nucleic acid construct of claim 1, wherein the Xa21 polynucleotide is as shown in SEQ ID NOs: 1, 4, 6, 8, 10, or
 11. 6. The nucleic acid construct of claim 1, further comprising a promoter operably linked to the RRK polynucleotide sequence.
 7. The nucleic acid construct of claim 1, wherein the promoter is a tissue-specific promoter.
 8. The nucleic acid construct of claim 1, wherein the promoter is a constitutive promoter.
 9. An isolated nucleic acid construct comprising a cassava RRK polynucleotide sequence, which polynucleotide hybridizes to SEQ ID NO: 13 under stringent conditions.
 10. The isolated nucleic acid construct of claim 9, which is SEQ ID NO:
 13. 11. An isolated nucleic acid construct comprising a maize RRK polynucleotide sequence, which polynucleotide hybridizes to SEQ ID NOs: 15 or 16 under stringent conditions.
 12. The isolated nucleic acid construct of claim 11, which is SEQ ID NO: 15 or SEQ ID NO:
 16. 13. An isolated nucleic acid construct comprising a tomato RRK polynucleotide sequence, which polynucleotide hybridizes to SEQ ID NOs: 17, 19, or 21 under stringent conditions.
 14. The isolated nucleic acid construct of claim 13, which is SEQ ID NO: 17, SEQ ID NO:19, or SEQ ID NO:21.
 15. A transgenic plant comprising a recombinant expression cassette comprising a plant promoter operably linked to a Xa21 polynucleotide sequence of claim
 1. 16. A method of enhancing resistance to Xanthomonas in a plant, the method comprising introducing into the plant a recombinant expression cassette comprising a plant promoter operably linked to an RRK polynucleotide sequence of claim
 1. 17. The method of claim 16, wherein the plant tissue is from rice.
 18. The method of claim 16, wherein the plant tissue is from tomato. 